Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis

A M Valdes; J Loughlin; K M Timms; J J B van Meurs; L Southam; S G Wilson; S Doherty; R J Lories; F P Luyten; A Gutin; V Abkevich; D Ge; A Hofman; A G Uitterlinden; D J Hart; F Zhang; G Zhai; R J Egli; M Doherty; J Lanchbury; T D Spector

doi:10.1016/j.ajhg.2008.04.006

Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis

A M Valdes, J Loughlin, K M Timms, J J B van Meurs, L Southam, S G Wilson, S Doherty, R J Lories, F P Luyten, A Gutin, V Abkevich, D Ge, A Hofman, A G Uitterlinden, D J Hart, F Zhang, G Zhai, R J Egli, M Doherty, J LanchburyT D Spector

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Abstract

Osteoarthritis (OA), the most prevalent form of arthritis in the elderly, is characterized by the degradation of articular cartilage and has a strong genetic component. Our aim was to identify genetic variants involved in risk of knee OA in women. A pooled genome-wide association scan with the Illumina550 Duo array was performed in 255 controls and 387 cases. Twenty-eight variants with p <1 x 10(-5) were estimated to have probabilities of being false positives

Original language	English
Pages (from-to)	1231 - 1240
Number of pages	10
Journal	American Journal of Human Genetics
Volume	82
Issue number	6
DOIs	https://doi.org/10.1016/j.ajhg.2008.04.006
Publication status	Published - 6 Jun 2008

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Valdes, A. M., Loughlin, J., Timms, K. M., van Meurs, J. J. B., Southam, L., Wilson, S. G., Doherty, S., Lories, R. J., Luyten, F. P., Gutin, A., Abkevich, V., Ge, D., Hofman, A., Uitterlinden, A. G., Hart, D. J., Zhang, F., Zhai, G., Egli, R. J., Doherty, M., ... Spector, T. D. (2008). Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis. American Journal of Human Genetics, 82(6), 1231 - 1240. https://doi.org/10.1016/j.ajhg.2008.04.006

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title = "Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis",

abstract = "Osteoarthritis (OA), the most prevalent form of arthritis in the elderly, is characterized by the degradation of articular cartilage and has a strong genetic component. Our aim was to identify genetic variants involved in risk of knee OA in women. A pooled genome-wide association scan with the Illumina550 Duo array was performed in 255 controls and 387 cases. Twenty-eight variants with p <1 x 10(-5) were estimated to have probabilities of being false positives ",

author = "Valdes, {A M} and J Loughlin and Timms, {K M} and {van Meurs}, {J J B} and L Southam and Wilson, {S G} and S Doherty and Lories, {R J} and Luyten, {F P} and A Gutin and V Abkevich and D Ge and A Hofman and Uitterlinden, {A G} and Hart, {D J} and F Zhang and G Zhai and Egli, {R J} and M Doherty and J Lanchbury and Spector, {T D}",

year = "2008",

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doi = "10.1016/j.ajhg.2008.04.006",

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Valdes, AM, Loughlin, J, Timms, KM, van Meurs, JJB, Southam, L, Wilson, SG, Doherty, S, Lories, RJ, Luyten, FP, Gutin, A, Abkevich, V, Ge, D, Hofman, A, Uitterlinden, AG, Hart, DJ, Zhang, F , Zhai, G, Egli, RJ, Doherty, M, Lanchbury, J & Spector, TD 2008, 'Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis', American Journal of Human Genetics, vol. 82, no. 6, pp. 1231 - 1240. https://doi.org/10.1016/j.ajhg.2008.04.006

TY - JOUR

T1 - Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis

AU - Valdes, A M

AU - Loughlin, J

AU - Timms, K M

AU - van Meurs, J J B

AU - Southam, L

AU - Wilson, S G

AU - Doherty, S

AU - Lories, R J

AU - Luyten, F P

AU - Gutin, A

AU - Abkevich, V

AU - Ge, D

AU - Hofman, A

AU - Uitterlinden, A G

AU - Hart, D J

AU - Zhang, F

AU - Zhai, G

AU - Egli, R J

AU - Doherty, M

AU - Lanchbury, J

AU - Spector, T D

PY - 2008/6/6

Y1 - 2008/6/6

N2 - Osteoarthritis (OA), the most prevalent form of arthritis in the elderly, is characterized by the degradation of articular cartilage and has a strong genetic component. Our aim was to identify genetic variants involved in risk of knee OA in women. A pooled genome-wide association scan with the Illumina550 Duo array was performed in 255 controls and 387 cases. Twenty-eight variants with p <1 x 10(-5) were estimated to have probabilities of being false positives

AB - Osteoarthritis (OA), the most prevalent form of arthritis in the elderly, is characterized by the degradation of articular cartilage and has a strong genetic component. Our aim was to identify genetic variants involved in risk of knee OA in women. A pooled genome-wide association scan with the Illumina550 Duo array was performed in 255 controls and 387 cases. Twenty-eight variants with p <1 x 10(-5) were estimated to have probabilities of being false positives

U2 - 10.1016/j.ajhg.2008.04.006

DO - 10.1016/j.ajhg.2008.04.006

M3 - Article

SN - 1537-6605

VL - 82

SP - 1231

EP - 1240

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 6

ER -

Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis

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