TY - JOUR
T1 - Genomically humanized mice
T2 - Technologies and promises
AU - Devoy, Anny
AU - Bunton-Stasyshyn, Rosie K.A.
AU - Tybulewicz, Victor L.J.
AU - Smith, Andrew J.H.
AU - Fisher, Elizabeth M.C.
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Mouse models have become an invaluable tool for understanding human health and disease owing to our ability to manipulate the mouse genome exquisitely. Recent progress in genomic analysis has led to an increase in the number and type of disease-causing mutations detected and has also highlighted the importance of non-coding regions. As a result, there is increasing interest in creating 'genomically' humanized mouse models, in which entire human genomic loci are transferred into the mouse genome. The technical challenges towards achieving this aim are large but are starting to be tackled with success.
AB - Mouse models have become an invaluable tool for understanding human health and disease owing to our ability to manipulate the mouse genome exquisitely. Recent progress in genomic analysis has led to an increase in the number and type of disease-causing mutations detected and has also highlighted the importance of non-coding regions. As a result, there is increasing interest in creating 'genomically' humanized mouse models, in which entire human genomic loci are transferred into the mouse genome. The technical challenges towards achieving this aim are large but are starting to be tackled with success.
UR - http://www.scopus.com/inward/record.url?scp=83755185527&partnerID=8YFLogxK
U2 - 10.1038/nrg3116
DO - 10.1038/nrg3116
M3 - Article
C2 - 22179716
AN - SCOPUS:83755185527
SN - 1471-0056
VL - 13
SP - 14
EP - 20
JO - NATURE REVIEWS GENETICS
JF - NATURE REVIEWS GENETICS
IS - 1
ER -
