TY - JOUR
T1 - Glatiramer acetate attenuates neuropathic allodynia through modulation of adaptive immune cells
AU - Leger, Tanya
AU - Grist, John
AU - D'Acquisto, Fulvio
AU - Clark, Anna K.
AU - Malcangio, Marzia
PY - 2011/5
Y1 - 2011/5
N2 - Immune-neuronal interactions contribute to neuropathic pain. Thus, immune-competent cells such as microglia may provide targets for pain relief, as may infiltrating lymphocytes. We evaluated the nature of the lymphocyte response in the spinal cord in association with the maintenance of neuropathic allodynia. We assessed T cell contribution to pain processing by targeting these cells with Glatiramer acetate (GA) which when administered systemically reversed neuropathic allodynia, inhibited microglia response and increased IL-10 and IL-4 expressing T cells in neuropathic dorsal horns. These studies advance understanding of lymphocyte contribution to chronic pain and reveal a new mechanism of T cell intervention. (C) 2011 Elsevier B.V. All rights reserved.
AB - Immune-neuronal interactions contribute to neuropathic pain. Thus, immune-competent cells such as microglia may provide targets for pain relief, as may infiltrating lymphocytes. We evaluated the nature of the lymphocyte response in the spinal cord in association with the maintenance of neuropathic allodynia. We assessed T cell contribution to pain processing by targeting these cells with Glatiramer acetate (GA) which when administered systemically reversed neuropathic allodynia, inhibited microglia response and increased IL-10 and IL-4 expressing T cells in neuropathic dorsal horns. These studies advance understanding of lymphocyte contribution to chronic pain and reveal a new mechanism of T cell intervention. (C) 2011 Elsevier B.V. All rights reserved.
U2 - 10.1016/j.jneuroim.2011.01.005
DO - 10.1016/j.jneuroim.2011.01.005
M3 - Article
VL - 234
SP - 19
EP - 26
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -