@article{70d633db7aab462aa21f98b896de5f6d,
title = "Global analysis of breast feeding and risk of symptoms of asthma, rhinoconjunctivitis and eczema in 6-7 year old children: ISAAC Phase Three",
abstract = "Background: In Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC), we investigated the relationship between breast feeding in infancy and symptoms of asthma, rhinoconjunctivitis and eczema in 6-7 year old children. Methods: Parents or guardians of 6-7 year old children completed written questionnaires on current symptoms of asthma, rhinoconjunctivitis and eczema, and on a range of possible asthma risk factors including a history of breast feeding ever. Prevalence odds ratios were estimated using logistic regression, adjusted for gender, region of the world, language, per capita gross national income, and other risk factors. Results: In all 206,453 children from 72 centres in 31 countries participated in the study. Reported breast feeding ever was not associated with current wheeze, with an odds ratio (adjusted for gender, region of the world, language, per capita gross national income, and factors encountered in infancy) of 0.99 (95% CI 0.92-1.05), current rhinoconjunctivitis (OR 1.00, 95% CI 0.93-1.08), current eczema (OR 1.05, 95% CI 0.97-1.12), or symptoms of severe asthma (OR 0.95, 95% CI 0.87-1.05). Breast feeding was however associated with a reduced risk of severe rhinoconjunctivitis (OR 0.74, 95% CI 0.59-0.94) and severe eczema (OR 0.79, 95% CI 0.66-0.95). Conclusions: There was no consistent association between breast feeding use in the first year of life and either a history or current symptoms of wheezing, rhinoconjunctivitis or eczema in 6-7 year old children, but possibly an effect on severe symptoms of the latter two conditions.",
keywords = "Asthma, Breast feeding, Eczema, ISAAC, Rhinoconjunctivitis",
author = "B. Bj{\"o}rkst{\'e}n and N. A{\"i}t-Khaled and Asher, {M. I.} and Clayton, {T. O.} and C. Robertson and Anderson, {H. R.} and R. Beasley and B. Brunekreef and J. Crane and P. Ellwood and C. Flohr and S. Foliaki and F. Forastiere and L. Garc{\'i}a-Marcos and U. Keil and Lai, {C. K.W.} and J. Mallol and Mitchell, {E. A.} and J. Odhiambo and S. Montefort and N. Pearce and Stewart, {A. W.} and D. Strachan and {von Mutius}, E. and Weiland, {S. K.} and H. Williams and G. Wong and Howitt, {M. E.} and J. Weyler and {de Freitas Souza}, L. and D. Rennie and P. Aguilar and G. Aristiz{\'a}bal and Cepeda, {A. M.} and Riikj{\"a}rv, {M. A.} and sigmond, {G. Z.} and S. Awasthi and S. Bhave and Hanumante, {N. M.} and Jain, {K. C.} and Mantri, {S. N.} and Joshi, {M. K.} and S. Rego and S. Salvi and Sharma, {S. K.} and C. Moyes and C. Nunes and Lee, {H. B.} and Huang, {J. L.} and Kao, {C. C.}",
note = "Funding Information: We are grateful to the children and parents who willingly cooperated and participated in ISAAC Phase Three and the coordination and assistance by the school staff is sincerely appreciated. We thank the Phase Three National Coordinators, Principal Investigators and their colleagues, who helped make ISAAC Phase Three such a success. We would like to acknowledge and thank the many funding bodies throughout the world that supported the individual ISAAC centres and collaborators and their meetings. In particular, we wish to thank the New Zealand funding bodies, the Health Research Council of New Zealand, the Asthma and Respiratory Foundation of New Zealand, the Child Health Research Foundation, the Hawke's Bay Medical Research Foundation, the Waikato Medical Research Foundation, Glaxo Wellcome New Zealand, the NZ Lottery Board and Astra Zeneca New Zealand. Glaxo Wellcome International Medical Affairs supported the Regional Coordination and the ISAAC International Data Centre. Without help from all of the above, ISAAC would not have given us all these results from so many countries. The Centre for Public Health Research is supported by a Programme Grant and Sunia Foliaki is supported by a Pacific Health Research Postdoctoral Fellowship from the Health Research Council of New Zealand. ",
year = "2011",
month = nov,
day = "1",
doi = "10.1016/j.aller.2011.02.005",
language = "English",
volume = "39",
pages = "318--325",
journal = "Allergologia et Immunopathologia",
issn = "0301-0546",
publisher = "Ediciones Doyma, S.L.",
number = "6",
}