@article{e0ba5328e1f040518b276aa2d6d43adb,
title = "Harnessing Mesenchymal Stromal Cells for the Engineering of Human Hematopoietic Niches",
abstract = "Tissue engineering opens multiple opportunities in regenerative medicine, drug testing, and modeling of the hematopoiesis in health and disease. Recapitulating the organization of physiological microenvironments supporting leukocyte development is essential to model faithfully the development of immune cells. Hematopoietic organs are shaped by spatially organized niches defined by multiple cellular contributions. A shared feature of immune niches is the presence of mesenchymal stromal cells endowed with unique roles in organizing niche development, maintenance, and function. Here, we review challenges and opportunities in harnessing stromal cells for the engineering of artificial immune niches and hematopoietic organoids recapitulating leukocyte ontogeny both in vitro and in vivo.",
keywords = "3D culture, bone marrow niche, hematopoiesis, mesenchymal stroma cell, organoids model, thymus epithelial cell",
author = "Alice Pievani and Roberto Savoldelli and Juliane Poelchen and Elisa Mattioli and Giorgio Anselmi and Alice Girardot and Jochen Utikal and Pierre Bourdely and Marta Serafini and Pierre Guermonprez",
note = "Funding Information: The research was supported by the BBSRC, NC3RS, WWCR, CRUK, Rosetrees Trust, CRUK King{\textquoteright}s Health Partners Cancer Centre; IDEX (ANR-18-IDEX-0001) and INCA (PL-BIO-ICR1), Institut Curie, Institut National de la Sant{\'e} et de la Recherche M{\'e}dicale, Labex DCBIOL (ANR-10-IDEX-0001-02 PSL, ANR-11-LABX0043). RS was founded by Cancer research UK (C604/A29283). MS research was supported by AIRC-5x1000 2018-21147. JP was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) Project number 259332240/ RTG 2099. Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Pievani, Savoldelli, Poelchen, Mattioli, Anselmi, Girardot, Utikal, Bourdely, Serafini and Guermonprez. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = mar,
day = "15",
doi = "10.3389/fimmu.2021.631279",
language = "English",
volume = "12",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media",
}