High affinity iron(III) scavenging by a novel hexadentate 3-hydroxypyridin-4-one-based dendrimer: Synthesis and characterization

T Zhou; Z D Liu; H Neubert; X Le Kong; Y M Ma; R C Hider

doi:10.1016/j.bmcl.2005.08.008

High affinity iron(III) scavenging by a novel hexadentate 3-hydroxypyridin-4-one-based dendrimer: Synthesis and characterization

T Zhou, Z D Liu, H Neubert, X Le Kong, Y M Ma, R C Hider

King's College London

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

The synthesis of a novel iron(III)-selective hydroxypyridinone hexadentate-terminated dendritic chelator based on a benzene tricarbonyl core polyamine dendrimer is described. The iron-chelating ability of the dendritic chelator was demonstrated by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and UV-vis spectroscopy. The physicochemical properties of the isolated hexadentate unit were also investigated. The dendrimer was found to possess an extremely high affinity for iron(II), namely logK = 34.8, pFe(3+) = 30.6. (c) 2005 Elsevier Ltd. All rights reserved

Original language	English
Pages (from-to)	5007 - 5011
Number of pages	5
Journal	BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS
Volume	15
Issue number	22
DOIs	https://doi.org/10.1016/j.bmcl.2005.08.008
Publication status	Published - 15 Nov 2005

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10.1016/j.bmcl.2005.08.008

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title = "High affinity iron(III) scavenging by a novel hexadentate 3-hydroxypyridin-4-one-based dendrimer: Synthesis and characterization",

abstract = "The synthesis of a novel iron(III)-selective hydroxypyridinone hexadentate-terminated dendritic chelator based on a benzene tricarbonyl core polyamine dendrimer is described. The iron-chelating ability of the dendritic chelator was demonstrated by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and UV-vis spectroscopy. The physicochemical properties of the isolated hexadentate unit were also investigated. The dendrimer was found to possess an extremely high affinity for iron(II), namely logK = 34.8, pFe(3+) = 30.6. (c) 2005 Elsevier Ltd. All rights reserved",

author = "T Zhou and Liu, {Z D} and H Neubert and {Le Kong}, X and Ma, {Y M} and Hider, {R C}",

year = "2005",

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doi = "10.1016/j.bmcl.2005.08.008",

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T1 - High affinity iron(III) scavenging by a novel hexadentate 3-hydroxypyridin-4-one-based dendrimer: Synthesis and characterization

AU - Zhou, T

AU - Liu, Z D

AU - Neubert, H

AU - Le Kong, X

AU - Ma, Y M

AU - Hider, R C

PY - 2005/11/15

Y1 - 2005/11/15

N2 - The synthesis of a novel iron(III)-selective hydroxypyridinone hexadentate-terminated dendritic chelator based on a benzene tricarbonyl core polyamine dendrimer is described. The iron-chelating ability of the dendritic chelator was demonstrated by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and UV-vis spectroscopy. The physicochemical properties of the isolated hexadentate unit were also investigated. The dendrimer was found to possess an extremely high affinity for iron(II), namely logK = 34.8, pFe(3+) = 30.6. (c) 2005 Elsevier Ltd. All rights reserved

AB - The synthesis of a novel iron(III)-selective hydroxypyridinone hexadentate-terminated dendritic chelator based on a benzene tricarbonyl core polyamine dendrimer is described. The iron-chelating ability of the dendritic chelator was demonstrated by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and UV-vis spectroscopy. The physicochemical properties of the isolated hexadentate unit were also investigated. The dendrimer was found to possess an extremely high affinity for iron(II), namely logK = 34.8, pFe(3+) = 30.6. (c) 2005 Elsevier Ltd. All rights reserved

U2 - 10.1016/j.bmcl.2005.08.008

DO - 10.1016/j.bmcl.2005.08.008

M3 - Article

SN - 1464-3405

VL - 15

SP - 5007

EP - 5011

JO - BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS

JF - BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS

IS - 22

ER -

High affinity iron(III) scavenging by a novel hexadentate 3-hydroxypyridin-4-one-based dendrimer: Synthesis and characterization

Abstract

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