Higher circulating bile acid concentrations in obese patients with type 2 diabetes

Royce Vincent; Sohail Omar; Samer Ghozlan; David R. Taylor; Gemma Cross; Roy Sherwood; Lars Fandriks; Torsten Olbers; Malin Werling; Jamshid Alaghband-Zadeh; Carel W. le Roux

doi:10.1177/0004563212473450

Higher circulating bile acid concentrations in obese patients with type 2 diabetes

Royce Vincent, Sohail Omar, Samer Ghozlan, David R. Taylor, Gemma Cross, Roy Sherwood, Lars Fandriks, Torsten Olbers, Malin Werling, Jamshid Alaghband-Zadeh, Carel W. le Roux

Research output: Contribution to journal › Article › peer-review

75 Citations (Scopus)

Abstract

Background: Bile acids (BAs) play an important role in releasing incretin hormones via the enteroendocrine L-cell surface TGR5 receptors. The aim of this study was to investigate the difference in BA concentration at baseline and in response to a meal stimulus between type 2 diabetes mellitus (T2DM) and a matched normoglycaemic group.

Materials and methods: A cross-sectional study of 12 patients with known T2DM and 12 matched normoglycaemic controls compared BA fractions after an overnight fast and following a standard meal.

Results: The T2DM group had higher baseline glucose (P<0.001), but baseline total BA, total glycine conjugated BAs (GCBA) and total taurine conjugated BA (TCBA) were similar between both groups. The T2DM group compared to the normoglycaemic group had a higher post-prandial peak change in total BAs 4.28 (3.51-5.38) mmol/L vs. 0.88 (0.60-1.57) mmol/L (P<0.001) and peak total GCBA 2.77 (1.07-4.19) mmol/L vs. 0.94 (0.34-1.15) mmol/L (P<0.0001), but similar peak total TCBA 0.36 (0.02-0.76) mmol/L vs. 0.08 (0.04-0.22) mmol/L (P 0.91).

Conclusion: The post-prandial bile acid response is elevated in obese patients with T2DM compared to matched normoglycaemic individuals.

Original language	English
Pages (from-to)	360-364
Number of pages	5
Journal	Annals of Clinical Biochemistry
Volume	50
Issue number	4
DOIs	https://doi.org/10.1177/0004563212473450
Publication status	Published - Jul 2013

Keywords

Bile acids
type 2 diabetes mellitus
glucagon like peptide-1
TGR5 receptor
CHOLESTEROL 7-ALPHA-HYDROXYLASE GENE
INSULIN SENSITIVITY
HUMAN HEPATOCYTES
GLUCOSE
PLASMA
PATHOPHYSIOLOGY
PHYSIOLOGY
INHIBIT

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/0004563212473450

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@article{c13867f782af48a49894aaa3f7908abd,

title = "Higher circulating bile acid concentrations in obese patients with type 2 diabetes",

abstract = "Background: Bile acids (BAs) play an important role in releasing incretin hormones via the enteroendocrine L-cell surface TGR5 receptors. The aim of this study was to investigate the difference in BA concentration at baseline and in response to a meal stimulus between type 2 diabetes mellitus (T2DM) and a matched normoglycaemic group.Materials and methods: A cross-sectional study of 12 patients with known T2DM and 12 matched normoglycaemic controls compared BA fractions after an overnight fast and following a standard meal.Results: The T2DM group had higher baseline glucose (P<0.001), but baseline total BA, total glycine conjugated BAs (GCBA) and total taurine conjugated BA (TCBA) were similar between both groups. The T2DM group compared to the normoglycaemic group had a higher post-prandial peak change in total BAs 4.28 (3.51-5.38) mmol/L vs. 0.88 (0.60-1.57) mmol/L (P<0.001) and peak total GCBA 2.77 (1.07-4.19) mmol/L vs. 0.94 (0.34-1.15) mmol/L (P<0.0001), but similar peak total TCBA 0.36 (0.02-0.76) mmol/L vs. 0.08 (0.04-0.22) mmol/L (P 0.91).Conclusion: The post-prandial bile acid response is elevated in obese patients with T2DM compared to matched normoglycaemic individuals.",

keywords = "Bile acids, type 2 diabetes mellitus, glucagon like peptide-1, TGR5 receptor, CHOLESTEROL 7-ALPHA-HYDROXYLASE GENE, INSULIN SENSITIVITY, HUMAN HEPATOCYTES, GLUCOSE, PLASMA, PATHOPHYSIOLOGY, PHYSIOLOGY, INHIBIT",

author = "Royce Vincent and Sohail Omar and Samer Ghozlan and Taylor, {David R.} and Gemma Cross and Roy Sherwood and Lars Fandriks and Torsten Olbers and Malin Werling and Jamshid Alaghband-Zadeh and {le Roux}, {Carel W.}",

year = "2013",

month = jul,

doi = "10.1177/0004563212473450",

language = "English",

volume = "50",

pages = "360--364",

journal = "Annals of Clinical Biochemistry",

issn = "0004-5632",

publisher = "SAGE Publications Ltd",

number = "4",

}

TY - JOUR

T1 - Higher circulating bile acid concentrations in obese patients with type 2 diabetes

AU - Vincent, Royce

AU - Omar, Sohail

AU - Ghozlan, Samer

AU - Taylor, David R.

AU - Cross, Gemma

AU - Sherwood, Roy

AU - Fandriks, Lars

AU - Olbers, Torsten

AU - Werling, Malin

AU - Alaghband-Zadeh, Jamshid

AU - le Roux, Carel W.

PY - 2013/7

Y1 - 2013/7

N2 - Background: Bile acids (BAs) play an important role in releasing incretin hormones via the enteroendocrine L-cell surface TGR5 receptors. The aim of this study was to investigate the difference in BA concentration at baseline and in response to a meal stimulus between type 2 diabetes mellitus (T2DM) and a matched normoglycaemic group.Materials and methods: A cross-sectional study of 12 patients with known T2DM and 12 matched normoglycaemic controls compared BA fractions after an overnight fast and following a standard meal.Results: The T2DM group had higher baseline glucose (P<0.001), but baseline total BA, total glycine conjugated BAs (GCBA) and total taurine conjugated BA (TCBA) were similar between both groups. The T2DM group compared to the normoglycaemic group had a higher post-prandial peak change in total BAs 4.28 (3.51-5.38) mmol/L vs. 0.88 (0.60-1.57) mmol/L (P<0.001) and peak total GCBA 2.77 (1.07-4.19) mmol/L vs. 0.94 (0.34-1.15) mmol/L (P<0.0001), but similar peak total TCBA 0.36 (0.02-0.76) mmol/L vs. 0.08 (0.04-0.22) mmol/L (P 0.91).Conclusion: The post-prandial bile acid response is elevated in obese patients with T2DM compared to matched normoglycaemic individuals.

AB - Background: Bile acids (BAs) play an important role in releasing incretin hormones via the enteroendocrine L-cell surface TGR5 receptors. The aim of this study was to investigate the difference in BA concentration at baseline and in response to a meal stimulus between type 2 diabetes mellitus (T2DM) and a matched normoglycaemic group.Materials and methods: A cross-sectional study of 12 patients with known T2DM and 12 matched normoglycaemic controls compared BA fractions after an overnight fast and following a standard meal.Results: The T2DM group had higher baseline glucose (P<0.001), but baseline total BA, total glycine conjugated BAs (GCBA) and total taurine conjugated BA (TCBA) were similar between both groups. The T2DM group compared to the normoglycaemic group had a higher post-prandial peak change in total BAs 4.28 (3.51-5.38) mmol/L vs. 0.88 (0.60-1.57) mmol/L (P<0.001) and peak total GCBA 2.77 (1.07-4.19) mmol/L vs. 0.94 (0.34-1.15) mmol/L (P<0.0001), but similar peak total TCBA 0.36 (0.02-0.76) mmol/L vs. 0.08 (0.04-0.22) mmol/L (P 0.91).Conclusion: The post-prandial bile acid response is elevated in obese patients with T2DM compared to matched normoglycaemic individuals.

KW - Bile acids

KW - type 2 diabetes mellitus

KW - glucagon like peptide-1

KW - TGR5 receptor

KW - CHOLESTEROL 7-ALPHA-HYDROXYLASE GENE

KW - INSULIN SENSITIVITY

KW - HUMAN HEPATOCYTES

KW - GLUCOSE

KW - PLASMA

KW - PATHOPHYSIOLOGY

KW - PHYSIOLOGY

KW - INHIBIT

U2 - 10.1177/0004563212473450

DO - 10.1177/0004563212473450

M3 - Article

SN - 0004-5632

VL - 50

SP - 360

EP - 364

JO - Annals of Clinical Biochemistry

JF - Annals of Clinical Biochemistry

IS - 4

ER -

Higher circulating bile acid concentrations in obese patients with type 2 diabetes

Abstract

Keywords

UN SDGs

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