TY - JOUR
T1 - Hippocampal abnormalities and age in chronic schizophrenia
T2 - Morphometric study across the adult lifespan
AU - Pujol, Núria
AU - Penadés, Rafael
AU - Junqué, Carme
AU - Dinov, Ivo
AU - Fu, Cynthia H Y
AU - Catalán, Rosa
AU - Ibarretxe-Bilbao, Naroa
AU - Bargalló, Núria
AU - Bernardo, Miquel
AU - Toga, Arthur
AU - Howard, Robert J.
AU - Costafreda, Sergi G.
PY - 2014/11
Y1 - 2014/11
N2 - Background: Hippocampal abnormalities have been demonstrated in schizophrenia. It is unclear whether these abnormalities worsen with age, and whether they affect cognition and function. Aims: To determine whether hippocampal abnormalities in chronic schizophrenia are associated with age, cognition and sociooccupational function. Method: Using 3 T magnetic resonance imaging we scanned 100 persons aged 19-82 years: 51 were out-patients with stable schizophrenia at least 2 years after diagnosis and 49 were healthy volunteers matched for age and gender. Automated analysis was used to determine hippocampal volume and shape. Results: There were differential effects of age in the schizophrenia and control samples on total hippocampal volume (group6age interaction: F(1,95) = 6.57, P = 0.012), with steeper age-related reduction in the schizophrenia group. Three-dimensional shape analysis located the age-related deformations predominantly in the mid-body of the hippocampus. In the schizophrenia group similar patterns of morphometric abnormalities were correlated with impaired cognition and poorer socio-occupational function. Conclusions: Hippocampal abnormalities are associated with age in people with chronic schizophrenia, with a steeper decline than in healthy individuals. These abnormalities are associated with cognitive and functional deficits, suggesting that hippocampal morphometry may be a biomarker for cognitive decline in older patients with schizophrenia.
AB - Background: Hippocampal abnormalities have been demonstrated in schizophrenia. It is unclear whether these abnormalities worsen with age, and whether they affect cognition and function. Aims: To determine whether hippocampal abnormalities in chronic schizophrenia are associated with age, cognition and sociooccupational function. Method: Using 3 T magnetic resonance imaging we scanned 100 persons aged 19-82 years: 51 were out-patients with stable schizophrenia at least 2 years after diagnosis and 49 were healthy volunteers matched for age and gender. Automated analysis was used to determine hippocampal volume and shape. Results: There were differential effects of age in the schizophrenia and control samples on total hippocampal volume (group6age interaction: F(1,95) = 6.57, P = 0.012), with steeper age-related reduction in the schizophrenia group. Three-dimensional shape analysis located the age-related deformations predominantly in the mid-body of the hippocampus. In the schizophrenia group similar patterns of morphometric abnormalities were correlated with impaired cognition and poorer socio-occupational function. Conclusions: Hippocampal abnormalities are associated with age in people with chronic schizophrenia, with a steeper decline than in healthy individuals. These abnormalities are associated with cognitive and functional deficits, suggesting that hippocampal morphometry may be a biomarker for cognitive decline in older patients with schizophrenia.
UR - http://www.scopus.com/inward/record.url?scp=84910020749&partnerID=8YFLogxK
U2 - 10.1192/bjp.bp.113.140384
DO - 10.1192/bjp.bp.113.140384
M3 - Article
AN - SCOPUS:84910020749
SN - 0007-1250
VL - 205
SP - 369
EP - 375
JO - British journal of psychiatry
JF - British journal of psychiatry
IS - 5
ER -
