TY - JOUR
T1 - Homeostasis, regeneration and tumour formation in the mammalian epidermis
AU - Belokhvostova, Daria
AU - Berzanskyte, Ieva
AU - Cujba, Ana-Maria
AU - Jowett, Geraldine
AU - Marshall, Lucy
AU - Prueller, Johanna
AU - Watt, Fiona M
PY - 2018
Y1 - 2018
N2 - The epidermis is the outer covering of the skin and provides a protective interface between the body and the environment. It is well established that the epidermis is maintained by stem cells that self-renew and generate differentiated cells. In this review, we discuss how recent technological advances, including single cell transcriptomics and in vivo imaging, have provided new insights into the nature and plasticity of the stem cell compartment and the differing roles of stem cells in homeostasis, wound repair and cancer.
AB - The epidermis is the outer covering of the skin and provides a protective interface between the body and the environment. It is well established that the epidermis is maintained by stem cells that self-renew and generate differentiated cells. In this review, we discuss how recent technological advances, including single cell transcriptomics and in vivo imaging, have provided new insights into the nature and plasticity of the stem cell compartment and the differing roles of stem cells in homeostasis, wound repair and cancer.
U2 - 10.1387/ijdb.170341fw
DO - 10.1387/ijdb.170341fw
M3 - Article
C2 - 29938768
SN - 0214-6282
VL - 62
SP - 571
EP - 582
JO - International Journal of Developmental Biology
JF - International Journal of Developmental Biology
IS - 6-7-8
ER -
