TY - JOUR
T1 - How Can We Improve the Vaccination Response in Older People? Part II
T2 - Targeting Immunosenescence of Adaptive Immunity Cells
AU - Garnica, Maider
AU - Aiello, Anna
AU - Ligotti, Mattia Emanuela
AU - Accardi, Giulia
AU - Arasanz, Hugo
AU - Bocanegra, Ana
AU - Blanco, Ester
AU - Calabrò, Anna
AU - Chocarro, Luisa
AU - Echaide, Miriam
AU - Kochan, Grazyna
AU - Fernandez-Rubio, Leticia
AU - Ramos, Pablo
AU - Pojero, Fanny
AU - Zareian, Nahid
AU - Piñeiro-Hermida, Sergio
AU - Farzaneh, Farzin
AU - Candore, Giuseppina
AU - Caruso, Calogero
AU - Escors, David
N1 - Funding Information:
The OncoImmunology group is funded by the Spanish Association Against Cancer (AECC, PROYE16001ESCO); Instituto de Salud Carlos III (ISCIII)-FEDER project grants (FIS PI17/02119, FIS PI20/00010, COV20/00000 and TRANSPOCART ICI19/00069); a Biomedicine Project grant from the Department of Health of the Government of Navarre (BMED 050-2019); strategic projects from the Department of Industry, Government of Navarre (AGATA, Ref 0011-1411-2020-000013; LINTERNA, Ref. 0011-1411-2020-000033; DESCARTHES, 0011-1411-2019-000058); Ministerio de Ciencia e Innovación (PID2019-108989RB-I00, PLEC2021-008094 MCIN/AEI/10.13039/501100011033) and the European Project Horizon 2020 Improved Vaccination for Older Adults (ISOLDA; Grant agreement ID: 848166). S. Piñeiro-Hermida thanks the La Caixa Foundation for his postdoctoral fellowship. Fanny Pojero was supported by Fondazione Umberto Veronesi.
Publisher Copyright:
© 2022 by the authors.
PY - 2022/8/29
Y1 - 2022/8/29
N2 - The number of people that are 65 years old or older has been increasing due to the improvement in medicine and public health. However, this trend is not accompanied by an increase in quality of life, and this population is vulnerable to most illnesses, especially to infectious diseases. Vaccination is the best strategy to prevent this fact, but older people present a less efficient response, as their immune system is weaker due mainly to a phenomenon known as immunosenescence. The adaptive immune system is constituted by two types of lymphocytes, T and B cells, and the function and fitness of these cell populations are affected during ageing. Here, we review the impact of ageing on T and B cells and discuss the approaches that have been described or proposed to modulate and reverse the decline of the ageing adaptive immune system.
AB - The number of people that are 65 years old or older has been increasing due to the improvement in medicine and public health. However, this trend is not accompanied by an increase in quality of life, and this population is vulnerable to most illnesses, especially to infectious diseases. Vaccination is the best strategy to prevent this fact, but older people present a less efficient response, as their immune system is weaker due mainly to a phenomenon known as immunosenescence. The adaptive immune system is constituted by two types of lymphocytes, T and B cells, and the function and fitness of these cell populations are affected during ageing. Here, we review the impact of ageing on T and B cells and discuss the approaches that have been described or proposed to modulate and reverse the decline of the ageing adaptive immune system.
KW - adaptive immunity
KW - aging
KW - B cells
KW - immunosenescence
KW - T cells
KW - vaccines
UR - http://www.scopus.com/inward/record.url?scp=85137595357&partnerID=8YFLogxK
U2 - 10.3390/ijms23179797
DO - 10.3390/ijms23179797
M3 - Review article
C2 - 36077216
AN - SCOPUS:85137595357
SN - 1661-6596
VL - 23
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 17
M1 - 9797
ER -
