Hybrid Mass Spectrometry: Towards Characterization of Protein Conformational States

Zainab Ahdash; Euan Pyle; Argyris Politis

doi:10.1016/j.tibs.2016.04.008

Hybrid Mass Spectrometry: Towards Characterization of Protein Conformational States

Zainab Ahdash, Euan Pyle, Argyris Politis

Chemistry

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9 Citations (Scopus)

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Abstract

A current challenge in structural biology is to unravel the conformational states of protein complexes. Hybrid mass spectrometry (MS) has emerged as a key tool to study the structural dynamics of large protein complexes unattainable by traditional methods. Here, we discuss recent advances in hybrid MS allowing characterization of challenging biological systems.

Original language	English
Journal	TRENDS IN BIOCHEMICAL SCIENCES
DOIs	https://doi.org/10.1016/j.tibs.2016.04.008
Publication status	E-pub ahead of print - 17 May 2016

Keywords

protein complexes
conformational states
hybrid approaches
mass spectrometry
integrative modelling

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10.1016/j.tibs.2016.04.008

TIBS_1252Accepted author manuscript, 1.38 MB

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title = "Hybrid Mass Spectrometry: Towards Characterization of Protein Conformational States",

abstract = "A current challenge in structural biology is to unravel the conformational states of protein complexes. Hybrid mass spectrometry (MS) has emerged as a key tool to study the structural dynamics of large protein complexes unattainable by traditional methods. Here, we discuss recent advances in hybrid MS allowing characterization of challenging biological systems.",

keywords = "protein complexes, conformational states, hybrid approaches, mass spectrometry, integrative modelling",

author = "Zainab Ahdash and Euan Pyle and Argyris Politis",

year = "2016",

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doi = "10.1016/j.tibs.2016.04.008",

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T2 - Towards Characterization of Protein Conformational States

AU - Ahdash, Zainab

AU - Pyle, Euan

AU - Politis, Argyris

PY - 2016/5/17

Y1 - 2016/5/17

N2 - A current challenge in structural biology is to unravel the conformational states of protein complexes. Hybrid mass spectrometry (MS) has emerged as a key tool to study the structural dynamics of large protein complexes unattainable by traditional methods. Here, we discuss recent advances in hybrid MS allowing characterization of challenging biological systems.

AB - A current challenge in structural biology is to unravel the conformational states of protein complexes. Hybrid mass spectrometry (MS) has emerged as a key tool to study the structural dynamics of large protein complexes unattainable by traditional methods. Here, we discuss recent advances in hybrid MS allowing characterization of challenging biological systems.

KW - protein complexes

KW - conformational states

KW - hybrid approaches

KW - mass spectrometry

KW - integrative modelling

U2 - 10.1016/j.tibs.2016.04.008

DO - 10.1016/j.tibs.2016.04.008

M3 - Article

SN - 0968-0004

JO - TRENDS IN BIOCHEMICAL SCIENCES

JF - TRENDS IN BIOCHEMICAL SCIENCES

ER -

Hybrid Mass Spectrometry: Towards Characterization of Protein Conformational States

Abstract

Keywords

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