Hypoxia imaging using PET and SPECT: the effects of anesthetic and carrier gas on [Cu]-ATSM, [Tc]-HL91 and [F]-FMISO tumor hypoxia accumulation

Veerle Kersemans; Bart Cornelissen; Rebekka Hueting; Matthew Tredwell; Kamila Hussien; Philip D Allen; Nadia Falzone; Sally A Hill; Jonathan R Dilworth; Veronique Gouverneur; Ruth J Muschel; Sean C Smart

doi:10.1371/journal.pone.0025911

Hypoxia imaging using PET and SPECT: the effects of anesthetic and carrier gas on [Cu]-ATSM, [Tc]-HL91 and [F]-FMISO tumor hypoxia accumulation

Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Philip D Allen, Nadia Falzone, Sally A Hill, Jonathan R Dilworth, Veronique Gouverneur, Ruth J Muschel, Sean C Smart

Imaging Chemistry & Biology

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Preclinical imaging requires anaesthesia to reduce motion-related artefacts. For direct translational relevance, anaesthesia must not significantly alter experimental outcome. This study reports on the effects of both anaesthetic and carrier gas upon the uptake of [⁶⁴Cu]-CuATSM, [(⁹⁹m)Tc]-HL91 and [¹⁸F]-FMISO in a preclinical model of tumor hypoxia.

Original language	English
Article number	e25911
Journal	PLoS ONE
Volume	6
Issue number	11
DOIs	https://doi.org/10.1371/journal.pone.0025911
Publication status	Published - 2011

Keywords

Adenocarcinoma
Anesthesia
Animals
Anoxia
Copper Radioisotopes
Female
Fluorine Radioisotopes
Gases
Mice
Mice, Inbred CBA
Misonidazole
Muscles
Neoplasms, Experimental
Organometallic Compounds
Organotechnetium Compounds
Oxygen
Positron-Emission Tomography
Radiation-Sensitizing Agents
Radiopharmaceuticals
Thiosemicarbazones
Tissue Distribution
Tomography, Emission-Computed, Single-Photon

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10.1371/journal.pone.0025911

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Kersemans, V., Cornelissen, B., Hueting, R., Tredwell, M., Hussien, K., Allen, P. D., Falzone, N., Hill, S. A., Dilworth, J. R., Gouverneur, V., Muschel, R. J., & Smart, S. C. (2011). Hypoxia imaging using PET and SPECT: the effects of anesthetic and carrier gas on [Cu]-ATSM, [Tc]-HL91 and [F]-FMISO tumor hypoxia accumulation. PLoS ONE, 6(11), Article e25911. https://doi.org/10.1371/journal.pone.0025911

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title = "Hypoxia imaging using PET and SPECT: the effects of anesthetic and carrier gas on [Cu]-ATSM, [Tc]-HL91 and [F]-FMISO tumor hypoxia accumulation",

abstract = "Preclinical imaging requires anaesthesia to reduce motion-related artefacts. For direct translational relevance, anaesthesia must not significantly alter experimental outcome. This study reports on the effects of both anaesthetic and carrier gas upon the uptake of [⁶⁴Cu]-CuATSM, [(⁹⁹m)Tc]-HL91 and [¹⁸F]-FMISO in a preclinical model of tumor hypoxia.",

keywords = "Adenocarcinoma, Anesthesia, Animals, Anoxia, Copper Radioisotopes, Female, Fluorine Radioisotopes, Gases, Mice, Mice, Inbred CBA, Misonidazole, Muscles, Neoplasms, Experimental, Organometallic Compounds, Organotechnetium Compounds, Oxygen, Positron-Emission Tomography, Radiation-Sensitizing Agents, Radiopharmaceuticals, Thiosemicarbazones, Tissue Distribution, Tomography, Emission-Computed, Single-Photon",

author = "Veerle Kersemans and Bart Cornelissen and Rebekka Hueting and Matthew Tredwell and Kamila Hussien and Allen, {Philip D} and Nadia Falzone and Hill, {Sally A} and Dilworth, {Jonathan R} and Veronique Gouverneur and Muschel, {Ruth J} and Smart, {Sean C}",

year = "2011",

doi = "10.1371/journal.pone.0025911",

language = "English",

volume = "6",

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Kersemans, V, Cornelissen, B, Hueting, R, Tredwell, M, Hussien, K, Allen, PD, Falzone, N, Hill, SA, Dilworth, JR, Gouverneur, V, Muschel, RJ & Smart, SC 2011, 'Hypoxia imaging using PET and SPECT: the effects of anesthetic and carrier gas on [Cu]-ATSM, [Tc]-HL91 and [F]-FMISO tumor hypoxia accumulation', PLoS ONE, vol. 6, no. 11, e25911. https://doi.org/10.1371/journal.pone.0025911

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T1 - Hypoxia imaging using PET and SPECT

T2 - the effects of anesthetic and carrier gas on [Cu]-ATSM, [Tc]-HL91 and [F]-FMISO tumor hypoxia accumulation

AU - Kersemans, Veerle

AU - Cornelissen, Bart

AU - Hueting, Rebekka

AU - Tredwell, Matthew

AU - Hussien, Kamila

AU - Allen, Philip D

AU - Falzone, Nadia

AU - Hill, Sally A

AU - Dilworth, Jonathan R

AU - Gouverneur, Veronique

AU - Muschel, Ruth J

AU - Smart, Sean C

PY - 2011

Y1 - 2011

N2 - Preclinical imaging requires anaesthesia to reduce motion-related artefacts. For direct translational relevance, anaesthesia must not significantly alter experimental outcome. This study reports on the effects of both anaesthetic and carrier gas upon the uptake of [⁶⁴Cu]-CuATSM, [(⁹⁹m)Tc]-HL91 and [¹⁸F]-FMISO in a preclinical model of tumor hypoxia.

AB - Preclinical imaging requires anaesthesia to reduce motion-related artefacts. For direct translational relevance, anaesthesia must not significantly alter experimental outcome. This study reports on the effects of both anaesthetic and carrier gas upon the uptake of [⁶⁴Cu]-CuATSM, [(⁹⁹m)Tc]-HL91 and [¹⁸F]-FMISO in a preclinical model of tumor hypoxia.

KW - Adenocarcinoma

KW - Anesthesia

KW - Animals

KW - Anoxia

KW - Copper Radioisotopes

KW - Female

KW - Fluorine Radioisotopes

KW - Gases

KW - Mice

KW - Mice, Inbred CBA

KW - Misonidazole

KW - Muscles

KW - Neoplasms, Experimental

KW - Organometallic Compounds

KW - Organotechnetium Compounds

KW - Oxygen

KW - Positron-Emission Tomography

KW - Radiation-Sensitizing Agents

KW - Radiopharmaceuticals

KW - Thiosemicarbazones

KW - Tissue Distribution

KW - Tomography, Emission-Computed, Single-Photon

U2 - 10.1371/journal.pone.0025911

DO - 10.1371/journal.pone.0025911

M3 - Article

C2 - 22102855

SN - 1932-6203

VL - 6

JO - PLoS ONE

JF - PLoS ONE

IS - 11

M1 - e25911

ER -

Hypoxia imaging using PET and SPECT: the effects of anesthetic and carrier gas on [Cu]-ATSM, [Tc]-HL91 and [F]-FMISO tumor hypoxia accumulation

Abstract

Keywords

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