Imaging Multiple Conductance States in an Alamethicin Pore

Lydia M. Harriss; Brid Cronin; James R. Thompson; Mark I. Wallace

doi:10.1021/ja204275t

Imaging Multiple Conductance States in an Alamethicin Pore

Lydia M. Harriss, Brid Cronin, James R. Thompson, Mark I. Wallace

Chemistry

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Alamethicin is the archetypal antimicrobial pore-forming peptide. Although the peptide has long been known to form pores of characteristic conductances in lipid membranes, the precise nature of these pores is not known. Simultaneous calcium-flux imaging and single-channel recording in a droplet interface bilayer allowed us to directly attribute multiple conductance states to a single point diffusing in the bilayer.

Original language	English
Pages (from-to)	14507-14509
Number of pages	3
Journal	J. Am. Chem. Soc.
Volume	133
Issue number	37
DOIs	https://doi.org/10.1021/ja204275t
Publication status	Published - 1 Sept 2011

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abstract = "Alamethicin is the archetypal antimicrobial pore-forming peptide. Although the peptide has long been known to form pores of characteristic conductances in lipid membranes, the precise nature of these pores is not known. Simultaneous calcium-flux imaging and single-channel recording in a droplet interface bilayer allowed us to directly attribute multiple conductance states to a single point diffusing in the bilayer.",

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AB - Alamethicin is the archetypal antimicrobial pore-forming peptide. Although the peptide has long been known to form pores of characteristic conductances in lipid membranes, the precise nature of these pores is not known. Simultaneous calcium-flux imaging and single-channel recording in a droplet interface bilayer allowed us to directly attribute multiple conductance states to a single point diffusing in the bilayer.

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DO - 10.1021/ja204275t

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JO - J. Am. Chem. Soc.

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Imaging Multiple Conductance States in an Alamethicin Pore

Abstract

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