Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005

A Tyndall; U A Walker; A Cope; Francesco Dazzi; C De Bari; W Fibbe; S Guiducci; S Jones; C Jorgensen; K Le Blanc; F Luyten; D McGonagle; I Martin; C Bocelli-Tyndall; G Pennesi; V Pistoia; C Pitzalis; A Uccelli; N Wulffraat; M Feldmann

doi:10.1186/ar2103

Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005

A Tyndall, U A Walker, A Cope, Francesco Dazzi, C De Bari, W Fibbe, S Guiducci, S Jones, C Jorgensen, K Le Blanc, F Luyten, D McGonagle, I Martin, C Bocelli-Tyndall, G Pennesi, V Pistoia, C Pitzalis, A Uccelli, N Wulffraat, M Feldmann

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Abstract

Multipotent mesenchymal stromal cells isolated from bone marrow and other sites are currently being studied to determine their potential role in the pathogenesis and/or management of autoimmune diseases. In vitro studies have shown that they exhibit a dose-dependent antiproliferative effect on T and B lymphocytes, dendritic cells, natural killer cells and various B cell tumour lines an effect that is both cell contact and soluble factor dependent. Animal models of autoimmune disease treated with multipotent mesenchymal stromal cells have mostly exhibited a positive clinical response, as have a limited number of patients suffering from acute graft versus host disease. This review summarizes the findings of a 1-day meeting devoted to the subject with the aim of coordinating efforts

Original language	English
Article number	301
Pages (from-to)	N/A
Number of pages	10
Journal	Arthritis Research and Therapy
Volume	9
Issue number	1
DOIs	https://doi.org/10.1186/ar2103
Publication status	Published - 29 Jan 2007

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Tyndall, A., Walker, U. A., Cope, A., Dazzi, F., De Bari, C., Fibbe, W., Guiducci, S., Jones, S., Jorgensen, C., Le Blanc, K., Luyten, F., McGonagle, D., Martin, I., Bocelli-Tyndall, C., Pennesi, G., Pistoia, V., Pitzalis, C., Uccelli, A., Wulffraat, N., & Feldmann, M. (2007). Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005. Arthritis Research and Therapy, 9(1), N/A. Article 301. https://doi.org/10.1186/ar2103

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title = "Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005",

abstract = "Multipotent mesenchymal stromal cells isolated from bone marrow and other sites are currently being studied to determine their potential role in the pathogenesis and/or management of autoimmune diseases. In vitro studies have shown that they exhibit a dose-dependent antiproliferative effect on T and B lymphocytes, dendritic cells, natural killer cells and various B cell tumour lines an effect that is both cell contact and soluble factor dependent. Animal models of autoimmune disease treated with multipotent mesenchymal stromal cells have mostly exhibited a positive clinical response, as have a limited number of patients suffering from acute graft versus host disease. This review summarizes the findings of a 1-day meeting devoted to the subject with the aim of coordinating efforts",

author = "A Tyndall and Walker, {U A} and A Cope and Francesco Dazzi and {De Bari}, C and W Fibbe and S Guiducci and S Jones and C Jorgensen and {Le Blanc}, K and F Luyten and D McGonagle and I Martin and C Bocelli-Tyndall and G Pennesi and V Pistoia and C Pitzalis and A Uccelli and N Wulffraat and M Feldmann",

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Tyndall, A, Walker, UA, Cope, A , Dazzi, F , De Bari, C, Fibbe, W, Guiducci, S, Jones, S, Jorgensen, C, Le Blanc, K, Luyten, F, McGonagle, D, Martin, I, Bocelli-Tyndall, C, Pennesi, G, Pistoia, V, Pitzalis, C, Uccelli, A, Wulffraat, N & Feldmann, M 2007, 'Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005', Arthritis Research and Therapy, vol. 9, no. 1, 301, pp. N/A. https://doi.org/10.1186/ar2103

Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005. / Tyndall, A; Walker, U A; Cope, A et al.
In: Arthritis Research and Therapy, Vol. 9, No. 1, 301, 29.01.2007, p. N/A.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Immunomodulatory properties of mesenchymal stem cells

T2 - a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005

AU - Tyndall, A

AU - Walker, U A

AU - Cope, A

AU - Dazzi, Francesco

AU - De Bari, C

AU - Fibbe, W

AU - Guiducci, S

AU - Jones, S

AU - Jorgensen, C

AU - Le Blanc, K

AU - Luyten, F

AU - McGonagle, D

AU - Martin, I

AU - Bocelli-Tyndall, C

AU - Pennesi, G

AU - Pistoia, V

AU - Pitzalis, C

AU - Uccelli, A

AU - Wulffraat, N

AU - Feldmann, M

PY - 2007/1/29

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AB - Multipotent mesenchymal stromal cells isolated from bone marrow and other sites are currently being studied to determine their potential role in the pathogenesis and/or management of autoimmune diseases. In vitro studies have shown that they exhibit a dose-dependent antiproliferative effect on T and B lymphocytes, dendritic cells, natural killer cells and various B cell tumour lines an effect that is both cell contact and soluble factor dependent. Animal models of autoimmune disease treated with multipotent mesenchymal stromal cells have mostly exhibited a positive clinical response, as have a limited number of patients suffering from acute graft versus host disease. This review summarizes the findings of a 1-day meeting devoted to the subject with the aim of coordinating efforts

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DO - 10.1186/ar2103

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ER -

Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005

Abstract

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