Impact of Statin Therapy on Central Aortic Pressures and Hemodynamics: Principal Results of the Conduit Artery Function Evaluation–Lipid-Lowering Arm (CAFE-LLA) Study

Bryan Williams; Peter S Lacy; J Kennedy Cruickshank; David Collier; Alun D Hughes; Alice Stanton; Simon Thom; Herbert Thurston; CAFE and ASCOT Investigators

doi:10.1161/CIRCULATIONAHA.108.785915

Impact of Statin Therapy on Central Aortic Pressures and Hemodynamics: Principal Results of the Conduit Artery Function Evaluation–Lipid-Lowering Arm (CAFE-LLA) Study

Bryan Williams, Peter S Lacy, J Kennedy Cruickshank, David Collier, Alun D Hughes, Alice Stanton, Simon Thom, Herbert Thurston, CAFE and ASCOT Investigators

Research output: Contribution to journal › Article › peer-review

92 Citations (Scopus)

Abstract

Statins reduce the risk of cardiovascular events in people with hypertension. This benefit could arise from a beneficial effect of statins on central aortic pressures and hemodynamics. The Conduit Artery Function Evaluation-Lipid-Lowering Arm (CAFE-LLA) study, an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) substudy, investigated this hypothesis in a prospective placebo-controlled study of treated patients with hypertension.

Original language	English
Pages (from-to)	53-61
Number of pages	9
Journal	Circulation (Baltimore)
Volume	119
Issue number	1
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.108.785915
Publication status	Published - 13 Jan 2009

Access to Document

10.1161/CIRCULATIONAHA.108.785915

Cite this

Williams, B., Lacy, P. S., Cruickshank, J. K., Collier, D., Hughes, A. D., Stanton, A., Thom, S., Thurston, H., & CAFE and ASCOT Investigators (2009). Impact of Statin Therapy on Central Aortic Pressures and Hemodynamics: Principal Results of the Conduit Artery Function Evaluation–Lipid-Lowering Arm (CAFE-LLA) Study. Circulation (Baltimore), 119(1), 53-61. https://doi.org/10.1161/CIRCULATIONAHA.108.785915

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Williams, B, Lacy, PS, Cruickshank, JK , Collier, D, Hughes, AD, Stanton, A, Thom, S, Thurston, H & CAFE and ASCOT Investigators 2009, 'Impact of Statin Therapy on Central Aortic Pressures and Hemodynamics: Principal Results of the Conduit Artery Function Evaluation–Lipid-Lowering Arm (CAFE-LLA) Study', Circulation (Baltimore), vol. 119, no. 1, pp. 53-61. https://doi.org/10.1161/CIRCULATIONAHA.108.785915

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