Importance of Proactive Treatment of Depression in Lewy Body Dementias: The Impact on Hippocampal Neurogenesis and Cognition in a Post-Mortem Study

Ariana Gatt; Antigoni Ekonomou; Alyma Somani; Sandrine Thuret; David Howlett; Anne Corbett; Mary Johnson; Elaine Perry; Johannes Attems; Paul Francis; Dag Aarsland; Clive Ballard

doi:10.1159/000484437

Importance of Proactive Treatment of Depression in Lewy Body Dementias: The Impact on Hippocampal Neurogenesis and Cognition in a Post-Mortem Study

Ariana Gatt, Antigoni Ekonomou, Alyma Somani, Sandrine Thuret, David Howlett, Anne Corbett, Mary Johnson, Elaine Perry, Johannes Attems, Paul Francis, Dag Aarsland, Clive Ballard

Health Psychology Section, Psychology Department, Institute of Psychology, Psychiatry and Neuroscience, King's College London, United Kingdom.

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

OBJECTIVE: To examine the impact of selective serotonin reuptake inhibitors (SSRIs) and depression on neurogenesis and cognition in dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD).

METHODS: Late-stage progenitor cells were quantified in the subgranular zone (SGZ) of the hippocampal dentate gyrus of DLB/PDD patients (n = 41) and controls without dementia (n = 15) and compared between treatment groups (unmedicated, SSRIs, acetyl cholinesterase inhibitors [AChEIs], combined SSRIs and AChEIs).

RESULTS: DLB/PDD patients had more doublecortin-positive cells in the SGZ compared to controls. The doublecortin-positive cell count was higher in the SGZ of patients treated with SSRIs and correlated to higher cognitive scores.

CONCLUSION: SSRI treatment was associated with increased hippocampal neurogenesis and preservation of cognition in DLB/PDD patients.

Original language	English
Pages (from-to)	283-293
Number of pages	11
Journal	Dementia and Geriatric Cognitive Disorders
Volume	44
Issue number	5-6
Early online date	27 Jan 2018
DOIs	https://doi.org/10.1159/000484437
Publication status	E-pub ahead of print - 27 Jan 2018

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Journal Article

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10.1159/000484437Licence: CC BY

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Gatt, A., Ekonomou, A., Somani, A., Thuret, S., Howlett, D., Corbett, A., Johnson, M., Perry, E., Attems, J., Francis, P., Aarsland, D., & Ballard, C. (2018). Importance of Proactive Treatment of Depression in Lewy Body Dementias: The Impact on Hippocampal Neurogenesis and Cognition in a Post-Mortem Study. Dementia and Geriatric Cognitive Disorders, 44(5-6), 283-293. Advance online publication. https://doi.org/10.1159/000484437

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title = "Importance of Proactive Treatment of Depression in Lewy Body Dementias: The Impact on Hippocampal Neurogenesis and Cognition in a Post-Mortem Study",

abstract = "OBJECTIVE: To examine the impact of selective serotonin reuptake inhibitors (SSRIs) and depression on neurogenesis and cognition in dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD).METHODS: Late-stage progenitor cells were quantified in the subgranular zone (SGZ) of the hippocampal dentate gyrus of DLB/PDD patients (n = 41) and controls without dementia (n = 15) and compared between treatment groups (unmedicated, SSRIs, acetyl cholinesterase inhibitors [AChEIs], combined SSRIs and AChEIs).RESULTS: DLB/PDD patients had more doublecortin-positive cells in the SGZ compared to controls. The doublecortin-positive cell count was higher in the SGZ of patients treated with SSRIs and correlated to higher cognitive scores.CONCLUSION: SSRI treatment was associated with increased hippocampal neurogenesis and preservation of cognition in DLB/PDD patients.",

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Gatt, A , Ekonomou, A, Somani, A, Thuret, S, Howlett, D, Corbett, A, Johnson, M, Perry, E, Attems, J, Francis, P , Aarsland, D & Ballard, C 2018, 'Importance of Proactive Treatment of Depression in Lewy Body Dementias: The Impact on Hippocampal Neurogenesis and Cognition in a Post-Mortem Study', Dementia and Geriatric Cognitive Disorders, vol. 44, no. 5-6, pp. 283-293. https://doi.org/10.1159/000484437

TY - JOUR

T1 - Importance of Proactive Treatment of Depression in Lewy Body Dementias

T2 - The Impact on Hippocampal Neurogenesis and Cognition in a Post-Mortem Study

AU - Gatt, Ariana

AU - Ekonomou, Antigoni

AU - Somani, Alyma

AU - Thuret, Sandrine

AU - Howlett, David

AU - Corbett, Anne

AU - Johnson, Mary

AU - Perry, Elaine

AU - Attems, Johannes

AU - Francis, Paul

AU - Aarsland, Dag

AU - Ballard, Clive

PY - 2018/1/27

Y1 - 2018/1/27

N2 - OBJECTIVE: To examine the impact of selective serotonin reuptake inhibitors (SSRIs) and depression on neurogenesis and cognition in dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD).METHODS: Late-stage progenitor cells were quantified in the subgranular zone (SGZ) of the hippocampal dentate gyrus of DLB/PDD patients (n = 41) and controls without dementia (n = 15) and compared between treatment groups (unmedicated, SSRIs, acetyl cholinesterase inhibitors [AChEIs], combined SSRIs and AChEIs).RESULTS: DLB/PDD patients had more doublecortin-positive cells in the SGZ compared to controls. The doublecortin-positive cell count was higher in the SGZ of patients treated with SSRIs and correlated to higher cognitive scores.CONCLUSION: SSRI treatment was associated with increased hippocampal neurogenesis and preservation of cognition in DLB/PDD patients.

AB - OBJECTIVE: To examine the impact of selective serotonin reuptake inhibitors (SSRIs) and depression on neurogenesis and cognition in dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD).METHODS: Late-stage progenitor cells were quantified in the subgranular zone (SGZ) of the hippocampal dentate gyrus of DLB/PDD patients (n = 41) and controls without dementia (n = 15) and compared between treatment groups (unmedicated, SSRIs, acetyl cholinesterase inhibitors [AChEIs], combined SSRIs and AChEIs).RESULTS: DLB/PDD patients had more doublecortin-positive cells in the SGZ compared to controls. The doublecortin-positive cell count was higher in the SGZ of patients treated with SSRIs and correlated to higher cognitive scores.CONCLUSION: SSRI treatment was associated with increased hippocampal neurogenesis and preservation of cognition in DLB/PDD patients.

KW - Journal Article

U2 - 10.1159/000484437

DO - 10.1159/000484437

M3 - Article

C2 - 29393203

SN - 1420-8008

VL - 44

SP - 283

EP - 293

JO - Dementia and Geriatric Cognitive Disorders

JF - Dementia and Geriatric Cognitive Disorders

IS - 5-6

ER -

Importance of Proactive Treatment of Depression in Lewy Body Dementias: The Impact on Hippocampal Neurogenesis and Cognition in a Post-Mortem Study

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