TY - JOUR
T1 - In Vivo Analysis of Dendritic Cell Development and Homeostasis
AU - Liu, Kang
AU - Victora, Gabriel D.
AU - Schwickert, Tanja A.
AU - Guermonprez, Pierre
AU - Meredith, Matthew M.
AU - Yao, Kaihui
AU - Chu, Fei-Fan
AU - Randolph, Gwendalyn J.
AU - Rudensky, Alexander Y.
AU - Nussenzweig, Michel
PY - 2009/4/17
Y1 - 2009/4/17
N2 - Dendritic cells (DCs) in lymphoid tissue arise from precursors that also produce monocytes and plasmacytoid DCs (pDCs). Where DC and monocyte lineage commitment occurs and the nature of the DC precursor that migrates from the bone marrow to peripheral lymphoid organs are unknown. We show that DC development progresses from the macrophage and DC precursor to common DC precursors that give rise to pDCs and classical spleen DCs (cDCs), but not monocytes, and finally to committed precursors of cDCs (pre-cDCs). Pre-cDCs enter lymph nodes through and migrate along high endothelial venules and later disperse and integrate into the DC network. Further cDC development involves cell division, which is controlled in part by regulatory T cells and fms-like tyrosine kinase receptor-3.
AB - Dendritic cells (DCs) in lymphoid tissue arise from precursors that also produce monocytes and plasmacytoid DCs (pDCs). Where DC and monocyte lineage commitment occurs and the nature of the DC precursor that migrates from the bone marrow to peripheral lymphoid organs are unknown. We show that DC development progresses from the macrophage and DC precursor to common DC precursors that give rise to pDCs and classical spleen DCs (cDCs), but not monocytes, and finally to committed precursors of cDCs (pre-cDCs). Pre-cDCs enter lymph nodes through and migrate along high endothelial venules and later disperse and integrate into the DC network. Further cDC development involves cell division, which is controlled in part by regulatory T cells and fms-like tyrosine kinase receptor-3.
U2 - 10.1126/science.1170540
DO - 10.1126/science.1170540
M3 - Article
SN - 1095-9203
VL - 324
SP - 392
EP - 397
JO - Science
JF - Science
IS - 5925
ER -