Increased peripheral blood mitochondrial DNA in type 2 diabetic patients with nephropathy

Afshan N Malik; Rojeen Shahni; Masud M Iqbal

doi:10.1016/j.diabres.2009.07.002

Increased peripheral blood mitochondrial DNA in type 2 diabetic patients with nephropathy

Afshan N Malik, Rojeen Shahni, Masud M Iqbal

Diabetes

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

We report that mitochondrial DNA (MtDNA) copy numbers are increased in peripheral blood of patients with diabetic nephropathy (DN). Using qPCR for quantitation, we found a 2–4-fold significant increase (p < 0.05) in the mean MtDNA values in DN patients vs. healthy controls and diabetics without nephropathy. Increased MtDNA in DN could contribute to increased oxidative stress.

Original language	English
Pages (from-to)	e22-e24
Number of pages	3
Journal	Diabetes Research and Clinical Practice
Volume	86
Issue number	2
DOIs	https://doi.org/10.1016/j.diabres.2009.07.002
Publication status	Published - Nov 2009

Keywords

Adult
Aged
Body Mass Index
DNA
DNA, Mitochondrial
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Diabetic Nephropathies
Humans
Middle Aged
Oxidative Stress

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diabres.2009.07.002

Cite this

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title = "Increased peripheral blood mitochondrial DNA in type 2 diabetic patients with nephropathy",

abstract = "We report that mitochondrial DNA (MtDNA) copy numbers are increased in peripheral blood of patients with diabetic nephropathy (DN). Using qPCR for quantitation, we found a 2–4-fold significant increase (p < 0.05) in the mean MtDNA values in DN patients vs. healthy controls and diabetics without nephropathy. Increased MtDNA in DN could contribute to increased oxidative stress.",

keywords = "Adult, Aged, Body Mass Index, DNA, DNA, Mitochondrial, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Humans, Middle Aged, Oxidative Stress",

author = "Malik, {Afshan N} and Rojeen Shahni and Iqbal, {Masud M}",

year = "2009",

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doi = "10.1016/j.diabres.2009.07.002",

language = "English",

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journal = "Diabetes Research and Clinical Practice",

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TY - JOUR

T1 - Increased peripheral blood mitochondrial DNA in type 2 diabetic patients with nephropathy

AU - Malik, Afshan N

AU - Shahni, Rojeen

AU - Iqbal, Masud M

PY - 2009/11

Y1 - 2009/11

N2 - We report that mitochondrial DNA (MtDNA) copy numbers are increased in peripheral blood of patients with diabetic nephropathy (DN). Using qPCR for quantitation, we found a 2–4-fold significant increase (p < 0.05) in the mean MtDNA values in DN patients vs. healthy controls and diabetics without nephropathy. Increased MtDNA in DN could contribute to increased oxidative stress.

AB - We report that mitochondrial DNA (MtDNA) copy numbers are increased in peripheral blood of patients with diabetic nephropathy (DN). Using qPCR for quantitation, we found a 2–4-fold significant increase (p < 0.05) in the mean MtDNA values in DN patients vs. healthy controls and diabetics without nephropathy. Increased MtDNA in DN could contribute to increased oxidative stress.

KW - Adult

KW - Aged

KW - Body Mass Index

KW - DNA

KW - DNA, Mitochondrial

KW - Diabetes Mellitus, Type 1

KW - Diabetes Mellitus, Type 2

KW - Diabetic Nephropathies

KW - Humans

KW - Middle Aged

KW - Oxidative Stress

U2 - 10.1016/j.diabres.2009.07.002

DO - 10.1016/j.diabres.2009.07.002

M3 - Article

C2 - 19660820

SN - 0168-8227

VL - 86

SP - e22-e24

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

IS - 2

ER -

Increased peripheral blood mitochondrial DNA in type 2 diabetic patients with nephropathy

Abstract

Keywords

UN SDGs

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