Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells

Nick Powell, Eirini Pantazi, Polychronis Pavlidis, Anastasia Tsakmaki, Katherine Li, Feifei Yang, Aimee Parker, Carmen Pin, Domenico Cozzetto, Danielle Minns, Emilie Stolarczyk, Svetlana Saveljeva, Rami Mohamed, Paul Lavender, Behdad Afzali, Jonathan Digby-Bell, Tsui Tjir-Li, Arthur Kaser, Joshua Friedman, Thomas T MacDonaldGavin A Bewick, Graham M Lord

School of Immunology and Microbial Sciences, King's College London, London, UK [email protected] [email protected].
From the Department of Pediatric Allergy, Division of Asthma, Allergy and Lung Biology, King's College London and Guy's and St. Thomas' NHS Foundation Trust, London (G.D.T., H.A.B., A.F.S., S.R., M.B., V.T., G.L.), and the University of Southampton and National Institute for Health Research Respiratory Biomedical Research Unit, Southampton and David Hide Centre, Newport, Isle of Wight (G.R.) - both in the United Kingdom; the Division of Hematology-Oncology, Department of Medicine, University of California, San Francisco, San Francisco (P.H.S.); Rho Federal Systems Division, Chapel Hill, NC (M.L.S., K.L., H.T.B.); and the Immune Tolerance Network (K.M.H.) and the National Institute of Allergy and Infectious Diseases (M.P.), Bethesda, MD.
Imperial College London
School of Immunology and Microbial Sciences, New Hunts House, Guy's Campus, King's College London, London, UK.
Diabetes Research Group, School of Life Course Sciences, Faculty of Life Sciences and Medicine, Kings College London, London, UK.
Janssen Research & Development LLC
Quadram Institute Bioscience
Department of Translational Bioinformatics, National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK.
Division of Gastroenterology and Hepatology, Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
Centre for Immunology and Infectious Disease, Bart's & the London School of Medicine and Dentistry, Blizard Institute of Cell and Molecular Science, London, UK.
Division of Informatics, Imaging and Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK; Nightingale Centre, University Hospital of South Manchester, Manchester, UK.

Research output: Contribution to journal › Review article › peer-review

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Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells

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Immunology and Microbiology