Intramolecular interactions in the polar headgroup of sphingosine: serinol

Donatella Loru; Isabel Peña; José L. Alonso; M. Eugenia Sanz

doi:10.1039/c5cc09423b

Intramolecular interactions in the polar headgroup of sphingosine: serinol

Donatella Loru, Isabel Peña, José L. Alonso, M. Eugenia Sanz^*

^*Corresponding author for this work

Chemistry

King's College London
Univ Valladolid, Consejo Superior de Investigaciones Cientificas (CSIC), Universidad de Valladolid, GEM, Unidad Asociada CSIC, Lab Bioespectroscopia

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The intramolecular interactions in the lipid sphingosine have been elucidated through the investigation of the amino alcohol serinol which mimics its polar headgroup. Intricate networks of intramolecular hydrogen bonds involving the hydroxyl groups and the amino group contribute to the stabilisation of five different conformations observed in the broadband rotational spectrum.

Original language	English
Pages (from-to)	3615-3618
Number of pages	4
Journal	CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY
Volume	52
Issue number	18
Early online date	15 Dec 2015
DOIs	https://doi.org/10.1039/c5cc09423b
Publication status	Published - 4 Mar 2016

Keywords

PROTEIN-KINASE-C
ROTATIONAL SPECTRUM
GAS-PHASE
CONFORMATIONS
SPHINGOLIPIDS
INHIBITION
CERAMIDE
GLYCEROL
DISEASE
ACID

Access to Document

10.1039/c5cc09423bLicence: CC BY

http://pubs.rsc.org/en/content/articlelanding/cc/2016/c5cc09423b#!divAbstractLicence: CC BY-NC

Cite this

@article{0aaa7afbcc4b4841bcab2c0cb2a26f98,

title = "Intramolecular interactions in the polar headgroup of sphingosine: serinol",

abstract = "The intramolecular interactions in the lipid sphingosine have been elucidated through the investigation of the amino alcohol serinol which mimics its polar headgroup. Intricate networks of intramolecular hydrogen bonds involving the hydroxyl groups and the amino group contribute to the stabilisation of five different conformations observed in the broadband rotational spectrum.",

keywords = "PROTEIN-KINASE-C, ROTATIONAL SPECTRUM, GAS-PHASE, CONFORMATIONS, SPHINGOLIPIDS, INHIBITION, CERAMIDE, GLYCEROL, DISEASE, ACID",

author = "Donatella Loru and Isabel Pe{\~n}a and Alonso, {Jos{\'e} L.} and Sanz, {M. Eugenia}",

year = "2016",

month = mar,

day = "4",

doi = "10.1039/c5cc09423b",

language = "English",

volume = "52",

pages = "3615--3618",

journal = "CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY",

issn = "1359-7345",

publisher = "ROYAL SOC CHEMISTRY",

number = "18",

}

TY - JOUR

T1 - Intramolecular interactions in the polar headgroup of sphingosine

T2 - serinol

AU - Loru, Donatella

AU - Peña, Isabel

AU - Alonso, José L.

AU - Sanz, M. Eugenia

PY - 2016/3/4

Y1 - 2016/3/4

N2 - The intramolecular interactions in the lipid sphingosine have been elucidated through the investigation of the amino alcohol serinol which mimics its polar headgroup. Intricate networks of intramolecular hydrogen bonds involving the hydroxyl groups and the amino group contribute to the stabilisation of five different conformations observed in the broadband rotational spectrum.

AB - The intramolecular interactions in the lipid sphingosine have been elucidated through the investigation of the amino alcohol serinol which mimics its polar headgroup. Intricate networks of intramolecular hydrogen bonds involving the hydroxyl groups and the amino group contribute to the stabilisation of five different conformations observed in the broadband rotational spectrum.

KW - PROTEIN-KINASE-C

KW - ROTATIONAL SPECTRUM

KW - GAS-PHASE

KW - CONFORMATIONS

KW - SPHINGOLIPIDS

KW - INHIBITION

KW - CERAMIDE

KW - GLYCEROL

KW - DISEASE

KW - ACID

U2 - 10.1039/c5cc09423b

DO - 10.1039/c5cc09423b

M3 - Article

SN - 1359-7345

VL - 52

SP - 3615

EP - 3618

JO - CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY

JF - CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY

IS - 18

ER -

Intramolecular interactions in the polar headgroup of sphingosine: serinol

Abstract

Keywords

Access to Document

Fingerprint

Cite this