Is there an association between the COMT gene and P300 endophenotypes?

E Bramon; E Dempster; S Frangou; C McDonald; P Schoenberg; J H Maccabe; M Walshe; P Sham; D Collier; R M Murray

doi:10.1016/j.eurpsy.2005.11.001

Is there an association between the COMT gene and P300 endophenotypes?

E Bramon, E Dempster, S Frangou, C McDonald, P Schoenberg, J H Maccabe, M Walshe, P Sham, D Collier, R M Murray

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Abstract

P300 wave anomalies correlate with genetic risk for schizophrenia and constitute a plausible endophenotype for the disease. The COMT gene is thought to influence cognitive performance and to be a susceptibility gene for schizophrenia. Unlike two previous studies, we found no significant influence of the COMT gene on P300 amplitude or latency in 189 individuals examined. The well-supported role of the COMT gene both in dopamine catabolism as well as in prefrontal cognition makes a strong theoretical case for the influence of COMT Va1158Met polymorphism on P300 endophenotypes. However, the available neurophysiologic evidence suggests that any Such association, if present, must be very subtle.

Original language	English
Pages (from-to)	70 - 73
Number of pages	4
Journal	European Psychiatry
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/j.eurpsy.2005.11.001
Publication status	Published - Jan 2006

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10.1016/j.eurpsy.2005.11.001

Cite this

@article{c5ff492b23484b0ea6513e73ff734da7,

title = "Is there an association between the COMT gene and P300 endophenotypes?",

abstract = "P300 wave anomalies correlate with genetic risk for schizophrenia and constitute a plausible endophenotype for the disease. The COMT gene is thought to influence cognitive performance and to be a susceptibility gene for schizophrenia. Unlike two previous studies, we found no significant influence of the COMT gene on P300 amplitude or latency in 189 individuals examined. The well-supported role of the COMT gene both in dopamine catabolism as well as in prefrontal cognition makes a strong theoretical case for the influence of COMT Va1158Met polymorphism on P300 endophenotypes. However, the available neurophysiologic evidence suggests that any Such association, if present, must be very subtle.",

author = "E Bramon and E Dempster and S Frangou and C McDonald and P Schoenberg and Maccabe, {J H} and M Walshe and P Sham and D Collier and Murray, {R M}",

year = "2006",

month = jan,

doi = "10.1016/j.eurpsy.2005.11.001",

language = "English",

volume = "21",

pages = "70 -- 73",

journal = "European Psychiatry",

issn = "1778-3585",