TY - JOUR
T1 - LARP4A and LARP4B in cancer
T2 - The new kids on the block
AU - Coleman, Jennifer C
AU - Hallett, Sadie R
AU - Grigoriadis, Agamemnon E
AU - Conte, Maria R
N1 - Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
Funding Information:
JCC and SH acknowledge support from a grant from the UK Medical Research Council ( MR/N013700/1 ) awarded as part of a Doctoral Training Partnership scholarship at King’s College London.
Funding Information:
JCC and SH acknowledge support from a grant from the UK Medical Research Council (MR/N013700/1) awarded as part of a Doctoral Training Partnership scholarship at King's College London.
Publisher Copyright:
© 2023 The Authors
PY - 2023/8
Y1 - 2023/8
N2 - Recent developments have mounted a stunning body of evidence underlying the importance of RNA binding proteins (RBPs) in cancer research. In this minireview we focus on LARP4A and LARP4B, two paralogs belonging to the superfamily of La-related proteins, and provide a critical overview of current research, including their roles in cancer pathogenesis and cell proliferation, migration, cell cycle and apoptosis. We highlight current controversies surrounding LARP4A and LARP4B and conclude that their complex roles in tumorigenesis are cell-, tissue- and context-dependent, warning that caution must be exercised before categorising either protein as an oncoprotein or tumour-suppressor. We also reveal that LARP4A and LARP4B have often been confused with one another, adding uncertainty in delineating their functions. We suggest that further functional and mechanistic studies of LARP4 proteins present significant challenges for future investigations to recognise the vital contributions of these RBPs in cancer research.
AB - Recent developments have mounted a stunning body of evidence underlying the importance of RNA binding proteins (RBPs) in cancer research. In this minireview we focus on LARP4A and LARP4B, two paralogs belonging to the superfamily of La-related proteins, and provide a critical overview of current research, including their roles in cancer pathogenesis and cell proliferation, migration, cell cycle and apoptosis. We highlight current controversies surrounding LARP4A and LARP4B and conclude that their complex roles in tumorigenesis are cell-, tissue- and context-dependent, warning that caution must be exercised before categorising either protein as an oncoprotein or tumour-suppressor. We also reveal that LARP4A and LARP4B have often been confused with one another, adding uncertainty in delineating their functions. We suggest that further functional and mechanistic studies of LARP4 proteins present significant challenges for future investigations to recognise the vital contributions of these RBPs in cancer research.
KW - Humans
KW - Ribonucleoproteins/genetics
KW - Autoantigens/genetics
KW - Neoplasms/genetics
KW - RNA-Binding Proteins/genetics
KW - Genes, Tumor Suppressor
UR - http://www.scopus.com/inward/record.url?scp=85163003960&partnerID=8YFLogxK
U2 - 10.1016/j.biocel.2023.106441
DO - 10.1016/j.biocel.2023.106441
M3 - Article
C2 - 37356415
SN - 1357-2725
VL - 161
SP - 106441
JO - The international journal of biochemistry & cell biology
JF - The international journal of biochemistry & cell biology
M1 - 106441
ER -
