TY - JOUR
T1 - Leptin/adiponectin ratio in patients with coronary heart disease
T2 - comparing subjects with and without metabolic syndrome
AU - Hall, J. I.
AU - Vora, N.
AU - Langworthy, R.
AU - Stock, S.
AU - Momin, A.
AU - Sherwood, Roy
AU - le Roux, C. W.
AU - Alaghband-Zadeh, J.
PY - 2011/7
Y1 - 2011/7
N2 - Background: Adiponectin and leptin are adipose tissue-derived hormones, shown to have opposing associations with the metabolic syndrome and coronary heart disease (CHD). This study evaluated the association between the leptin/adiponectin ratio and the components of the metabolic syndrome in a cohort with CND.Methods and results: This cross-sectional study included data from 105 subjects (men = 91), undergoing first-time elective coronary artery bypass grafting (CABG). Leptin and adiponectin concentrations were determined by enzyme-linked immunosorbent assay (ELISA). Association was found between the leptin/adiponectin ratio and homeostatic model assessment (HOMA) (r(s) = 0.34, P = 0.0006), fasting insulin concentrations (r(s) = 0.37, P = 0.0001), fasting glucose concentrations (r(s) = 0.24, P = 0.01), systolic blood pressure (r(s) = 0.20, P = 0.05), diastolic blood pressure (r(s) = 0.24, P = 0.02), waist circumference (r(s) = 0.55, P <0.0001), body mass index (BMI) (r(s) = 0.55, P <0.0001) and waist/hip ratio (r(s) = 0.38, P = 0.0001). A significant difference was found in ratios between those with and without insulin resistance (HOMA > 3 and HOMA Conclusion: In patients with severe CHD, the leptin/adiponectin ratio was not found to be a robust tool to distinguish patients with and without insulin resistance and those with and without the metabolic syndrome.
AB - Background: Adiponectin and leptin are adipose tissue-derived hormones, shown to have opposing associations with the metabolic syndrome and coronary heart disease (CHD). This study evaluated the association between the leptin/adiponectin ratio and the components of the metabolic syndrome in a cohort with CND.Methods and results: This cross-sectional study included data from 105 subjects (men = 91), undergoing first-time elective coronary artery bypass grafting (CABG). Leptin and adiponectin concentrations were determined by enzyme-linked immunosorbent assay (ELISA). Association was found between the leptin/adiponectin ratio and homeostatic model assessment (HOMA) (r(s) = 0.34, P = 0.0006), fasting insulin concentrations (r(s) = 0.37, P = 0.0001), fasting glucose concentrations (r(s) = 0.24, P = 0.01), systolic blood pressure (r(s) = 0.20, P = 0.05), diastolic blood pressure (r(s) = 0.24, P = 0.02), waist circumference (r(s) = 0.55, P <0.0001), body mass index (BMI) (r(s) = 0.55, P <0.0001) and waist/hip ratio (r(s) = 0.38, P = 0.0001). A significant difference was found in ratios between those with and without insulin resistance (HOMA > 3 and HOMA Conclusion: In patients with severe CHD, the leptin/adiponectin ratio was not found to be a robust tool to distinguish patients with and without insulin resistance and those with and without the metabolic syndrome.
KW - INTIMA-MEDIA THICKNESS
KW - CONGENITAL LEPTIN DEFICIENCY
KW - ADIPONECTIN RATIO
KW - MONICA/KORA AUGSBURG
KW - PLASMA ADIPONECTIN
KW - OBESITY
KW - KINASE
KW - INDEX
KW - RISK
U2 - 10.1258/acb.2011.010199
DO - 10.1258/acb.2011.010199
M3 - Article
SN - 0004-5632
VL - 48
SP - 327
EP - 331
JO - Annals of Clinical Biochemistry
JF - Annals of Clinical Biochemistry
ER -
