Leveraging NMR and X-ray Data of the Free Ligands to Build Better Drugs Targeting Angiotensin II Type 1 G-Protein Coupled Receptor

Tahsin F. Kellici; Dimitrios Ntountaniotis; Eftichia Kritsi; Maria Zervou; Panagiotis Zoumpoulakis; Constantinos Potamitis; Serdar Durdagi; Ramin Ekhteiari Salmas; Gizem Ergun; Ebru Gokdemir; Maria Halabalaki; Ioannis P. Gerothanassis; George Liapakis; Andreas G. Tzakos; Thomas Mavromoustakos

Leveraging NMR and X-ray Data of the Free Ligands to Build Better Drugs Targeting Angiotensin II Type 1 G-Protein Coupled Receptor

Tahsin F. Kellici, Dimitrios Ntountaniotis, Eftichia Kritsi, Maria Zervou, Panagiotis Zoumpoulakis, Constantinos Potamitis, Serdar Durdagi, Ramin Ekhteiari Salmas, Gizem Ergun, Ebru Gokdemir, Maria Halabalaki, Ioannis P. Gerothanassis, George Liapakis, Andreas G. Tzakos, Thomas Mavromoustakos

Chemistry

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Original language	English
Pages (from-to)	36-59
Journal	Current Medicinal Chemistry
Volume	23
Issue number	1
Publication status	Published - 2016

Keywords

Angiotensin II type 1 receptor antagonists
conformational analysis
NMR
molecular modeling
sartans
X-ray
GPCR
AT(1)R

Cite this

Kellici, T. F., Ntountaniotis, D., Kritsi, E., Zervou, M., Zoumpoulakis, P., Potamitis, C., Durdagi, S., Salmas, R. E., Ergun, G., Gokdemir, E., Halabalaki, M., Gerothanassis, I. P., Liapakis, G., Tzakos, A. G., & Mavromoustakos, T. (2016). Leveraging NMR and X-ray Data of the Free Ligands to Build Better Drugs Targeting Angiotensin II Type 1 G-Protein Coupled Receptor. Current Medicinal Chemistry, 23(1), 36-59.

@article{20bd128a35ab471db3670f755a623709,

title = "Leveraging NMR and X-ray Data of the Free Ligands to Build Better Drugs Targeting Angiotensin II Type 1 G-Protein Coupled Receptor",

keywords = "Angiotensin II type 1 receptor antagonists, conformational analysis, NMR, molecular modeling, sartans, X-ray, GPCR, AT(1)R",

author = "Kellici, {Tahsin F.} and Dimitrios Ntountaniotis and Eftichia Kritsi and Maria Zervou and Panagiotis Zoumpoulakis and Constantinos Potamitis and Serdar Durdagi and Salmas, {Ramin Ekhteiari} and Gizem Ergun and Ebru Gokdemir and Maria Halabalaki and Gerothanassis, {Ioannis P.} and George Liapakis and Tzakos, {Andreas G.} and Thomas Mavromoustakos",

year = "2016",

language = "English",

volume = "23",

pages = "36--59",

journal = "Current Medicinal Chemistry",

issn = "0929-8673",

publisher = "Bentham Science Publishers B.V.",

number = "1",

}

Kellici, TF, Ntountaniotis, D, Kritsi, E, Zervou, M, Zoumpoulakis, P, Potamitis, C, Durdagi, S, Salmas, RE, Ergun, G, Gokdemir, E, Halabalaki, M, Gerothanassis, IP, Liapakis, G, Tzakos, AG & Mavromoustakos, T 2016, 'Leveraging NMR and X-ray Data of the Free Ligands to Build Better Drugs Targeting Angiotensin II Type 1 G-Protein Coupled Receptor', Current Medicinal Chemistry, vol. 23, no. 1, pp. 36-59.

TY - JOUR

T1 - Leveraging NMR and X-ray Data of the Free Ligands to Build Better Drugs Targeting Angiotensin II Type 1 G-Protein Coupled Receptor

AU - Kellici, Tahsin F.

AU - Ntountaniotis, Dimitrios

AU - Kritsi, Eftichia

AU - Zervou, Maria

AU - Zoumpoulakis, Panagiotis

AU - Potamitis, Constantinos

AU - Durdagi, Serdar

AU - Salmas, Ramin Ekhteiari

AU - Ergun, Gizem

AU - Gokdemir, Ebru

AU - Halabalaki, Maria

AU - Gerothanassis, Ioannis P.

AU - Liapakis, George

AU - Tzakos, Andreas G.

AU - Mavromoustakos, Thomas

PY - 2016

Y1 - 2016

KW - Angiotensin II type 1 receptor antagonists

KW - conformational analysis

KW - NMR

KW - molecular modeling

KW - sartans

KW - X-ray

KW - GPCR

KW - AT(1)R

M3 - Article

SN - 0929-8673

VL - 23

SP - 36

EP - 59

JO - Current Medicinal Chemistry

JF - Current Medicinal Chemistry

IS - 1

ER -