Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence

Chiara De Lucia; Tytus Amadeusz Murphy; Claire Joanne Steves; Richard James Butler Dobson; Petroula Proitsi; Sandrine Thuret

doi:10.1038/s42003-020-0844-1

Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence

Chiara De Lucia, Tytus Amadeusz Murphy, Claire Joanne Steves, Richard James Butler Dobson, Petroula Proitsi, Sandrine Thuret

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28 Citations (Scopus)

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Abstract

Aging induces cellular and molecular changes including modification of stem cell pools. In particular, alterations in aging neural stem cells (NSCs) are linked to age-related cognitive decline which can be modulated by lifestyle. Nutrient-sensing pathways provide a molecular basis for the link between lifestyle and cognitive decline.
Adopting a back-translation strategy using stem cell biology to inform epidemiological analyses, here we show associations between cellular readouts of NSC maintenance and expression levels of nutrient-sensing genes following NSC exposure to aging human serum as well as morphological and gene expression alterations following repeated passaging. Epidemiological analyses on the identified genes showed associations between polymorphisms in SIRT1 and ABTB1 and cognitive performance as well as interactions between SIRT1 genotype and physical activity and between GRB10 genotype and adherence to a Mediterranean diet.
Our study contributes to the understanding of neural stem cell molecular mechanisms underlying human cognitive aging and hints at lifestyle modifiable factors.

Original language	English
Article number	157
Pages (from-to)	1-17
Journal	Communications Biology
Volume	3
Early online date	2 Apr 2020
DOIs	https://doi.org/10.1038/s42003-020-0844-1
Publication status	Published - 2020

Keywords

Insulin
nsulin-like growth-factor1 signaling
ISS
mTOR
Sirtuin
GBR10
ABTB1
NSC
Mediterranean diet
Exercise
Paired Associates Learning

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10.1038/s42003-020-0844-1Licence: CC BY

Lifestyle mediates the role_DE LUCIA_Acc20Feb2020Epub4Apr2020_GOLD VoR(CC BY)Final published version, 2.74 MBLicence: CC BY

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@article{95548b6594d9423f920733ba3c87474f,

title = "Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence",

abstract = "Aging induces cellular and molecular changes including modification of stem cell pools. In particular, alterations in aging neural stem cells (NSCs) are linked to age-related cognitive decline which can be modulated by lifestyle. Nutrient-sensing pathways provide a molecular basis for the link between lifestyle and cognitive decline. Adopting a back-translation strategy using stem cell biology to inform epidemiological analyses, here we show associations between cellular readouts of NSC maintenance and expression levels of nutrient-sensing genes following NSC exposure to aging human serum as well as morphological and gene expression alterations following repeated passaging. Epidemiological analyses on the identified genes showed associations between polymorphisms in SIRT1 and ABTB1 and cognitive performance as well as interactions between SIRT1 genotype and physical activity and between GRB10 genotype and adherence to a Mediterranean diet.Our study contributes to the understanding of neural stem cell molecular mechanisms underlying human cognitive aging and hints at lifestyle modifiable factors. ",

keywords = "Insulin, nsulin-like growth-factor1 signaling, ISS, mTOR, Sirtuin, GBR10, ABTB1, NSC, Mediterranean diet, Exercise, Paired Associates Learning",

author = "{De Lucia}, Chiara and Murphy, {Tytus Amadeusz} and Steves, {Claire Joanne} and Dobson, {Richard James Butler} and Petroula Proitsi and Sandrine Thuret",

year = "2020",

doi = "10.1038/s42003-020-0844-1",

language = "English",

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journal = "Communications Biology",

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T2 - cellular and epidemiological evidence

AU - De Lucia, Chiara

AU - Murphy, Tytus Amadeusz

AU - Steves, Claire Joanne

AU - Dobson, Richard James Butler

AU - Proitsi, Petroula

AU - Thuret, Sandrine

PY - 2020

Y1 - 2020

N2 - Aging induces cellular and molecular changes including modification of stem cell pools. In particular, alterations in aging neural stem cells (NSCs) are linked to age-related cognitive decline which can be modulated by lifestyle. Nutrient-sensing pathways provide a molecular basis for the link between lifestyle and cognitive decline. Adopting a back-translation strategy using stem cell biology to inform epidemiological analyses, here we show associations between cellular readouts of NSC maintenance and expression levels of nutrient-sensing genes following NSC exposure to aging human serum as well as morphological and gene expression alterations following repeated passaging. Epidemiological analyses on the identified genes showed associations between polymorphisms in SIRT1 and ABTB1 and cognitive performance as well as interactions between SIRT1 genotype and physical activity and between GRB10 genotype and adherence to a Mediterranean diet.Our study contributes to the understanding of neural stem cell molecular mechanisms underlying human cognitive aging and hints at lifestyle modifiable factors.

AB - Aging induces cellular and molecular changes including modification of stem cell pools. In particular, alterations in aging neural stem cells (NSCs) are linked to age-related cognitive decline which can be modulated by lifestyle. Nutrient-sensing pathways provide a molecular basis for the link between lifestyle and cognitive decline. Adopting a back-translation strategy using stem cell biology to inform epidemiological analyses, here we show associations between cellular readouts of NSC maintenance and expression levels of nutrient-sensing genes following NSC exposure to aging human serum as well as morphological and gene expression alterations following repeated passaging. Epidemiological analyses on the identified genes showed associations between polymorphisms in SIRT1 and ABTB1 and cognitive performance as well as interactions between SIRT1 genotype and physical activity and between GRB10 genotype and adherence to a Mediterranean diet.Our study contributes to the understanding of neural stem cell molecular mechanisms underlying human cognitive aging and hints at lifestyle modifiable factors.

KW - Insulin

KW - nsulin-like growth-factor1 signaling

KW - ISS

KW - mTOR

KW - Sirtuin

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KW - NSC

KW - Mediterranean diet

KW - Exercise

KW - Paired Associates Learning

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JO - Communications Biology

JF - Communications Biology

M1 - 157

ER -

Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence

Abstract

Keywords

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Does The Ageing Systemic Milieu Alter Neural Stem Cell Activity? : Cellular And Molecular Evidence From A Human System

Investigating Nutrient-Sensing Pathways in Ageing Human Neural Stem Cells and Age-Related Cognitive Decline

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Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence

Abstract

Keywords

Access to Document

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Student theses

Does The Ageing Systemic Milieu Alter Neural Stem Cell Activity? : Cellular And Molecular Evidence From A Human System

Investigating Nutrient-Sensing Pathways in Ageing Human Neural Stem Cells and Age-Related Cognitive Decline

Cite this