TY - JOUR
T1 - Liver microRNAs
T2 - Potential mediators and biomarkers for metabolic and cardiovascular disease?
AU - Willeit, Peter
AU - Skroblin, Philipp
AU - Kiechl, Stefan
AU - Fernández-Hernando, Carlos
AU - Mayr, Manuel
PY - 2016
Y1 - 2016
N2 - Recent discoveries have revealed that microRNAs (miRNAs) play a key role in the regulation of gene expression. In this review, we summarize the rapidly evolving knowledge about liver miRNAs (including miR-33, -33∗, miR-223, -30c, -144, -148a, -24, -29, and -122) and their link to hepatic lipid metabolism, atherosclerosis and cardiovascular disease, non-alcoholic fatty liver disease, metabolic syndrome, and type-2 diabetes. With regards to its biomarker potential, the main focus is on miR-122 as the most abundant liver miRNA with exquisite tissue specificity. MiR-122 has been proposed to play a central role in the maintenance of lipid and glucose homeostasis and is consistently detectable in serum and plasma. This miRNA may therefore constitute a novel biomarker for cardiovascular and metabolic diseases.
AB - Recent discoveries have revealed that microRNAs (miRNAs) play a key role in the regulation of gene expression. In this review, we summarize the rapidly evolving knowledge about liver miRNAs (including miR-33, -33∗, miR-223, -30c, -144, -148a, -24, -29, and -122) and their link to hepatic lipid metabolism, atherosclerosis and cardiovascular disease, non-alcoholic fatty liver disease, metabolic syndrome, and type-2 diabetes. With regards to its biomarker potential, the main focus is on miR-122 as the most abundant liver miRNA with exquisite tissue specificity. MiR-122 has been proposed to play a central role in the maintenance of lipid and glucose homeostasis and is consistently detectable in serum and plasma. This miRNA may therefore constitute a novel biomarker for cardiovascular and metabolic diseases.
KW - Biomarkers
KW - Cardiovascular disease
KW - Lipid metabolism
KW - MicroRNAs
UR - http://www.scopus.com/inward/record.url?scp=85013641196&partnerID=8YFLogxK
U2 - 10.1093/eurheartj/ehw146
DO - 10.1093/eurheartj/ehw146
M3 - Review article
AN - SCOPUS:85013641196
SN - 0195-668X
VL - 37
SP - 3260
EP - 3266
JO - European Heart Journal
JF - European Heart Journal
IS - 43
ER -
