Localization of human flavin-containing monooxygenase genes FMO2 and FMO5 to chromosome 1q

R R McCombie; C T Dolphin; S Povey; I R Phillips; E A Shephard

doi:10.1006/geno.1996.0308

Localization of human flavin-containing monooxygenase genes FMO2 and FMO5 to chromosome 1q

R R McCombie, C T Dolphin, S Povey, I R Phillips, E A Shephard

Institute of Pharmaceutical Science

UCL University College London

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

The human flavin-containing monooxygenase (FMO) gene family comprises at least five distinct members (FMO1 to FMO5) that code for enzymes responsible for the oxidation of a wide variety of soft nucleophilic substrates, including drugs and environmental pollutants. Three of these genes (FMO1, FMO3, and FMO4) have previously been localized to human chromosome 1q, raising the possibility that the entire gene family is clustered in this chromosomal region. Analysis by polymerase chain reaction of DNA isolated from a panel of human-rodent somatic cell hybrids demonstrates that the two remaining identified members of the FMO gene family, FMO2 and FMO5, also are located on chromosome 1q.

Original language	English
Pages (from-to)	426-429
Number of pages	4
Journal	Genomics
Volume	34
Issue number	3
DOIs	https://doi.org/10.1006/geno.1996.0308
Publication status	Published - 15 Jun 1996

Keywords

Animals
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 1
Cloning, Molecular
Codon
Cricetinae
DNA Primers
DNA, Complementary
Humans
Hybrid Cells
Liver
Molecular Sequence Data
Multigene Family
Oxygenases
Polymerase Chain Reaction
Recombinant Proteins
Substrate Specificity

Access to Document

10.1006/geno.1996.0308

Cite this

@article{989734c81fdc4492b575f730830b3b6c,

title = "Localization of human flavin-containing monooxygenase genes FMO2 and FMO5 to chromosome 1q",

abstract = "The human flavin-containing monooxygenase (FMO) gene family comprises at least five distinct members (FMO1 to FMO5) that code for enzymes responsible for the oxidation of a wide variety of soft nucleophilic substrates, including drugs and environmental pollutants. Three of these genes (FMO1, FMO3, and FMO4) have previously been localized to human chromosome 1q, raising the possibility that the entire gene family is clustered in this chromosomal region. Analysis by polymerase chain reaction of DNA isolated from a panel of human-rodent somatic cell hybrids demonstrates that the two remaining identified members of the FMO gene family, FMO2 and FMO5, also are located on chromosome 1q.",

keywords = "Animals, Base Sequence, Chromosome Mapping, Chromosomes, Human, Pair 1, Cloning, Molecular, Codon, Cricetinae, DNA Primers, DNA, Complementary, Humans, Hybrid Cells, Liver, Molecular Sequence Data, Multigene Family, Oxygenases, Polymerase Chain Reaction, Recombinant Proteins, Substrate Specificity",

author = "McCombie, {R R} and Dolphin, {C T} and S Povey and Phillips, {I R} and Shephard, {E A}",

year = "1996",

month = jun,

day = "15",

doi = "10.1006/geno.1996.0308",

language = "English",

volume = "34",

pages = "426--429",

journal = "Genomics",

issn = "0888-7543",

publisher = "ACADEMIC PRESS INC",

number = "3",

}

TY - JOUR

T1 - Localization of human flavin-containing monooxygenase genes FMO2 and FMO5 to chromosome 1q

AU - McCombie, R R

AU - Dolphin, C T

AU - Povey, S

AU - Phillips, I R

AU - Shephard, E A

PY - 1996/6/15

Y1 - 1996/6/15

N2 - The human flavin-containing monooxygenase (FMO) gene family comprises at least five distinct members (FMO1 to FMO5) that code for enzymes responsible for the oxidation of a wide variety of soft nucleophilic substrates, including drugs and environmental pollutants. Three of these genes (FMO1, FMO3, and FMO4) have previously been localized to human chromosome 1q, raising the possibility that the entire gene family is clustered in this chromosomal region. Analysis by polymerase chain reaction of DNA isolated from a panel of human-rodent somatic cell hybrids demonstrates that the two remaining identified members of the FMO gene family, FMO2 and FMO5, also are located on chromosome 1q.

AB - The human flavin-containing monooxygenase (FMO) gene family comprises at least five distinct members (FMO1 to FMO5) that code for enzymes responsible for the oxidation of a wide variety of soft nucleophilic substrates, including drugs and environmental pollutants. Three of these genes (FMO1, FMO3, and FMO4) have previously been localized to human chromosome 1q, raising the possibility that the entire gene family is clustered in this chromosomal region. Analysis by polymerase chain reaction of DNA isolated from a panel of human-rodent somatic cell hybrids demonstrates that the two remaining identified members of the FMO gene family, FMO2 and FMO5, also are located on chromosome 1q.

KW - Animals

KW - Base Sequence

KW - Chromosome Mapping

KW - Chromosomes, Human, Pair 1

KW - Cloning, Molecular

KW - Codon

KW - Cricetinae

KW - DNA Primers

KW - DNA, Complementary

KW - Humans

KW - Hybrid Cells

KW - Liver

KW - Molecular Sequence Data

KW - Multigene Family

KW - Oxygenases

KW - Polymerase Chain Reaction

KW - Recombinant Proteins

KW - Substrate Specificity

U2 - 10.1006/geno.1996.0308

DO - 10.1006/geno.1996.0308

M3 - Article

C2 - 8786146

SN - 0888-7543

VL - 34

SP - 426

EP - 429

JO - Genomics

JF - Genomics

IS - 3

ER -

Localization of human flavin-containing monooxygenase genes FMO2 and FMO5 to chromosome 1q

Abstract

Keywords

Access to Document

Fingerprint

Cite this