Long-wave UVA offers partial protection against UVB-induced immune suppression in human skin

L Skov; L Villadsen; B K Ersboll; J C Simon; J N W N Barker; O Baadsgaard

doi:10.1111/j.1600-0463.2000.tb00005.x

Long-wave UVA offers partial protection against UVB-induced immune suppression in human skin

L Skov, L Villadsen, B K Ersboll, J C Simon, J N W N Barker, O Baadsgaard

Dermatology

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Ultraviolet-B (UVB, 280-320 nm) interferes with the generation of cell-mediated immunity to contact allergens applied epicutaneously on the irradiated site. To investigate whether pretreatment with UVA-1 (340-400 mm) protects against the UVB-induced immune suppression we sensitized human volunteers with diphenylcyclopropenone (DPCP) on normal buttock skin (n=12), on UVB-irradiated buttock skin (n=21), on buttock skin pretreated with UVA-1 (n=12), and on buttock skin pretreated with UVA-1 and thereafter irradiated with UVB (n=22). Sensitization on UVB-irradiated skin reduced the immunization rate to DPCP compared with sensitization on non-irradiated skin (p

Original language	English
Pages (from-to)	825 - 830
Number of pages	6
Journal	Apmis
Volume	108
Issue number	12
DOIs	https://doi.org/10.1111/j.1600-0463.2000.tb00005.x
Publication status	Published - 2000

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abstract = "Ultraviolet-B (UVB, 280-320 nm) interferes with the generation of cell-mediated immunity to contact allergens applied epicutaneously on the irradiated site. To investigate whether pretreatment with UVA-1 (340-400 mm) protects against the UVB-induced immune suppression we sensitized human volunteers with diphenylcyclopropenone (DPCP) on normal buttock skin (n=12), on UVB-irradiated buttock skin (n=21), on buttock skin pretreated with UVA-1 (n=12), and on buttock skin pretreated with UVA-1 and thereafter irradiated with UVB (n=22). Sensitization on UVB-irradiated skin reduced the immunization rate to DPCP compared with sensitization on non-irradiated skin (p",

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AU - Skov, L

AU - Villadsen, L

AU - Ersboll, B K

AU - Simon, J C

AU - Barker, J N W N

AU - Baadsgaard, O

PY - 2000

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Long-wave UVA offers partial protection against UVB-induced immune suppression in human skin

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