Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus

P Forabosco; J D Gorman; C Cleveland; J A Kelly; S A Fisher; W A Ortmann; C Johansson; B Johanneson; K L Moser; P M Gaffney; B P Tsao; R M Cantor; M E arcon-Riquelme; T W Behrens; J B Harley; C M Lewis; L A Criswell

doi:10.1038/sj.gene.6364338

Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus

P Forabosco, J D Gorman, C Cleveland, J A Kelly, S A Fisher, W A Ortmann, C Johansson, B Johanneson, K L Moser, P M Gaffney, B P Tsao, R M Cantor, M E arcon-Riquelme, T W Behrens, J B Harley, C M Lewis, L A Criswell

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Abstract

A genetic contribution to the development of systemic lupus erythematosus (SLE) is well established. Several genome-wide linkage scans have identified a number of putative susceptibility loci for SLE, some of which have been replicated in independent samples. This study aimed to identify the regions showing the most consistent evidence for linkage by applying the genome scan meta-analysis (GSMA) method. The study identified two genome-wide suggestive regions on 6p21.1 - q15 and 20p11 - q13.13 (P-value = 0.0056 and P-value = 0.0044, respectively) and a region with P-value <0.01 on 16p13 - q12.2. The region on chromosome 6 contains the human leukocyte antigen cluster, and the chromosome 16 and 20 regions have been replicated in several cohorts. The potential importance of the identified genomic regions are also highlighted. These results, in conjunction with data emerging from dense single nucleotide polymorphism typing of specific regions or future genome-wide association studies will help guide efforts to identify the actual predisposing genetic variation contributing to this complex genetic disease

Original language	English
Pages (from-to)	609 - 614
Number of pages	6
Journal	GENES AND IMMUNITY
Volume	7
Issue number	7
DOIs	https://doi.org/10.1038/sj.gene.6364338
Publication status	Published - Oct 2006

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Forabosco, P., Gorman, J. D., Cleveland, C., Kelly, J. A., Fisher, S. A., Ortmann, W. A., Johansson, C., Johanneson, B., Moser, K. L., Gaffney, P. M., Tsao, B. P., Cantor, R. M., arcon-Riquelme, M. E., Behrens, T. W., Harley, J. B., Lewis, C. M., & Criswell, L. A. (2006). Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus. GENES AND IMMUNITY, 7(7), 609 - 614. https://doi.org/10.1038/sj.gene.6364338

@article{ff03ed42d067477ca56a175e54532858,

title = "Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus",

abstract = "A genetic contribution to the development of systemic lupus erythematosus (SLE) is well established. Several genome-wide linkage scans have identified a number of putative susceptibility loci for SLE, some of which have been replicated in independent samples. This study aimed to identify the regions showing the most consistent evidence for linkage by applying the genome scan meta-analysis (GSMA) method. The study identified two genome-wide suggestive regions on 6p21.1 - q15 and 20p11 - q13.13 (P-value = 0.0056 and P-value = 0.0044, respectively) and a region with P-value <0.01 on 16p13 - q12.2. The region on chromosome 6 contains the human leukocyte antigen cluster, and the chromosome 16 and 20 regions have been replicated in several cohorts. The potential importance of the identified genomic regions are also highlighted. These results, in conjunction with data emerging from dense single nucleotide polymorphism typing of specific regions or future genome-wide association studies will help guide efforts to identify the actual predisposing genetic variation contributing to this complex genetic disease",

author = "P Forabosco and Gorman, {J D} and C Cleveland and Kelly, {J A} and Fisher, {S A} and Ortmann, {W A} and C Johansson and B Johanneson and Moser, {K L} and Gaffney, {P M} and Tsao, {B P} and Cantor, {R M} and arcon-Riquelme, {M E} and Behrens, {T W} and Harley, {J B} and Lewis, {C M} and Criswell, {L A}",

year = "2006",

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doi = "10.1038/sj.gene.6364338",

language = "English",

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Forabosco, P, Gorman, JD, Cleveland, C, Kelly, JA, Fisher, SA, Ortmann, WA, Johansson, C, Johanneson, B, Moser, KL, Gaffney, PM, Tsao, BP, Cantor, RM, arcon-Riquelme, ME, Behrens, TW, Harley, JB, Lewis, CM & Criswell, LA 2006, 'Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus', GENES AND IMMUNITY, vol. 7, no. 7, pp. 609 - 614. https://doi.org/10.1038/sj.gene.6364338

TY - JOUR

T1 - Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus

AU - Forabosco, P

AU - Gorman, J D

AU - Cleveland, C

AU - Kelly, J A

AU - Fisher, S A

AU - Ortmann, W A

AU - Johansson, C

AU - Johanneson, B

AU - Moser, K L

AU - Gaffney, P M

AU - Tsao, B P

AU - Cantor, R M

AU - arcon-Riquelme, M E

AU - Behrens, T W

AU - Harley, J B

AU - Lewis, C M

AU - Criswell, L A

PY - 2006/10

Y1 - 2006/10

N2 - A genetic contribution to the development of systemic lupus erythematosus (SLE) is well established. Several genome-wide linkage scans have identified a number of putative susceptibility loci for SLE, some of which have been replicated in independent samples. This study aimed to identify the regions showing the most consistent evidence for linkage by applying the genome scan meta-analysis (GSMA) method. The study identified two genome-wide suggestive regions on 6p21.1 - q15 and 20p11 - q13.13 (P-value = 0.0056 and P-value = 0.0044, respectively) and a region with P-value <0.01 on 16p13 - q12.2. The region on chromosome 6 contains the human leukocyte antigen cluster, and the chromosome 16 and 20 regions have been replicated in several cohorts. The potential importance of the identified genomic regions are also highlighted. These results, in conjunction with data emerging from dense single nucleotide polymorphism typing of specific regions or future genome-wide association studies will help guide efforts to identify the actual predisposing genetic variation contributing to this complex genetic disease

AB - A genetic contribution to the development of systemic lupus erythematosus (SLE) is well established. Several genome-wide linkage scans have identified a number of putative susceptibility loci for SLE, some of which have been replicated in independent samples. This study aimed to identify the regions showing the most consistent evidence for linkage by applying the genome scan meta-analysis (GSMA) method. The study identified two genome-wide suggestive regions on 6p21.1 - q15 and 20p11 - q13.13 (P-value = 0.0056 and P-value = 0.0044, respectively) and a region with P-value <0.01 on 16p13 - q12.2. The region on chromosome 6 contains the human leukocyte antigen cluster, and the chromosome 16 and 20 regions have been replicated in several cohorts. The potential importance of the identified genomic regions are also highlighted. These results, in conjunction with data emerging from dense single nucleotide polymorphism typing of specific regions or future genome-wide association studies will help guide efforts to identify the actual predisposing genetic variation contributing to this complex genetic disease

U2 - 10.1038/sj.gene.6364338

DO - 10.1038/sj.gene.6364338

M3 - Article

VL - 7

SP - 609

EP - 614

JO - GENES AND IMMUNITY

JF - GENES AND IMMUNITY

IS - 7

ER -

Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus

Abstract

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