Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice

Volker M. Arlt, Marie Stiborová, Colin J Henderson, Markus Thiemann, Eva Frei, Dagmar Aimová, Rajinder Singh, Gonçalo Gamboa da Costa, Oliver J Schmitz, Peter B Farmer, C Roland Wolf, David H Phillips

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Pharmacology, Toxicology and Pharmaceutical Science