Mid-term prognostic value of coronary artery disease in patients undergoing transcatheter aortic valve implantation: A meta-analysis of adjusted observational results

F. D'Ascenzo; F. Conrotto; F. Giordana; C. Moretti; M. D'Amico; S. Salizzoni; P. Omede; M. La Torre; Martyn Thomas; D. Hildick-Smith; Gp. Ussia; M. Barbanti; C. Tamburino; John Webb; R. B. Schnabel; M. Seiffert; S. Wilde; H. Treede; V. Gasparetto; M. Napodano; G. Tarantini; P. Presbitero; M. Mennuni; M. L. Rossi; M. Gasparini; G. Biondi Zoccai; M. Lupo; M. Rinaldi; F. Gaita; S. Marra

doi:10.1016/j.ijcard.2013.03.062

Mid-term prognostic value of coronary artery disease in patients undergoing transcatheter aortic valve implantation: A meta-analysis of adjusted observational results

F. D'Ascenzo^*, F. Conrotto, F. Giordana, C. Moretti, M. D'Amico, S. Salizzoni, P. Omede, M. La Torre, Martyn Thomas, D. Hildick-Smith, Gp. Ussia, M. Barbanti, C. Tamburino, John Webb, R. B. Schnabel, M. Seiffert, S. Wilde, H. Treede, V. Gasparetto, M. NapodanoG. Tarantini, P. Presbitero, M. Mennuni, M. L. Rossi, M. Gasparini, G. Biondi Zoccai, M. Lupo, M. Rinaldi, F. Gaita, S. Marra

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

111 Citations (Scopus)

Abstract

Aims: Coronary artery disease (CAD) negatively affects prognosis in patients undergoing surgical aortic valve replacement, being currently evaluated in the most common used risk score. Our meta-analysis aims to clarify the prognostic role of CAD on mid-term survival in patients undergoing TAVI.

Methods and results: Studies reporting multivariate predictors of adverse outcomes in patients undergoing TAVI were systematically searched for and pooled, when appropriate, using a random-effect method. 960 citations were first screened and finally 7 studies (2472 patients) were included. Diagnosis of CAD was reported in 52%(42-65) of patients and 1169 Edwards SAPIEN and 1303 CoreValve prostheses were implanted. After a median follow up of 452 days (357-585) 24% of patients (19-33) died, and 23 (14-32) for cardiovascular death. At pooled analysis of multivariate approach, diagnosis of coronary artery disease did not increase risk of death (OR 1.0, 95% CI, confidence interval, 0.67-1.50 I-2 0%).

Conclusion: CAD does not affect mid-term TAVI outcome: this finding should be weighted to accurately evaluate risk and strategies for patients with severe aortic stenosis.

Original language	English
Pages (from-to)	2528-2532
Number of pages	5
Journal	International Journal of Cardiology
Volume	168
Issue number	3
DOIs	https://doi.org/10.1016/j.ijcard.2013.03.062
Publication status	Published - 3 Oct 2013

Keywords

TAVI
CAD
Mid-term outcomes
HIGH-RISK PATIENTS
SYSTEMATIC REVIEWS
EJECTION FRACTION
STENOSIS
OUTCOMES
REPLACEMENT
IMPACT
INTERVENTION
MORTALITY
REGISTRY

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10.1016/j.ijcard.2013.03.062

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D'Ascenzo, F., Conrotto, F., Giordana, F., Moretti, C., D'Amico, M., Salizzoni, S., Omede, P., La Torre, M., Thomas, M., Hildick-Smith, D., Ussia, G., Barbanti, M., Tamburino, C., Webb, J., Schnabel, R. B., Seiffert, M., Wilde, S., Treede, H., Gasparetto, V., ... Marra, S. (2013). Mid-term prognostic value of coronary artery disease in patients undergoing transcatheter aortic valve implantation: A meta-analysis of adjusted observational results. International Journal of Cardiology, 168(3), 2528-2532. https://doi.org/10.1016/j.ijcard.2013.03.062

@article{fd0586ff8ded410bae92e68ff0ebcb54,

title = "Mid-term prognostic value of coronary artery disease in patients undergoing transcatheter aortic valve implantation: A meta-analysis of adjusted observational results",

abstract = "Aims: Coronary artery disease (CAD) negatively affects prognosis in patients undergoing surgical aortic valve replacement, being currently evaluated in the most common used risk score. Our meta-analysis aims to clarify the prognostic role of CAD on mid-term survival in patients undergoing TAVI. Methods and results: Studies reporting multivariate predictors of adverse outcomes in patients undergoing TAVI were systematically searched for and pooled, when appropriate, using a random-effect method. 960 citations were first screened and finally 7 studies (2472 patients) were included. Diagnosis of CAD was reported in 52%(42-65) of patients and 1169 Edwards SAPIEN and 1303 CoreValve prostheses were implanted. After a median follow up of 452 days (357-585) 24% of patients (19-33) died, and 23 (14-32) for cardiovascular death. At pooled analysis of multivariate approach, diagnosis of coronary artery disease did not increase risk of death (OR 1.0, 95% CI, confidence interval, 0.67-1.50 I-2 0%). Conclusion: CAD does not affect mid-term TAVI outcome: this finding should be weighted to accurately evaluate risk and strategies for patients with severe aortic stenosis.",

keywords = "TAVI, CAD, Mid-term outcomes, HIGH-RISK PATIENTS, SYSTEMATIC REVIEWS, EJECTION FRACTION, STENOSIS, OUTCOMES, REPLACEMENT, IMPACT, INTERVENTION, MORTALITY, REGISTRY",

author = "F. D'Ascenzo and F. Conrotto and F. Giordana and C. Moretti and M. D'Amico and S. Salizzoni and P. Omede and {La Torre}, M. and Martyn Thomas and D. Hildick-Smith and Gp. Ussia and M. Barbanti and C. Tamburino and John Webb and Schnabel, {R. B.} and M. Seiffert and S. Wilde and H. Treede and V. Gasparetto and M. Napodano and G. Tarantini and P. Presbitero and M. Mennuni and Rossi, {M. L.} and M. Gasparini and Zoccai, {G. Biondi} and M. Lupo and M. Rinaldi and F. Gaita and S. Marra",

year = "2013",

month = oct,

day = "3",

doi = "10.1016/j.ijcard.2013.03.062",

language = "English",

volume = "168",

pages = "2528--2532",

journal = "International Journal of Cardiology",

issn = "0167-5273",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

D'Ascenzo, F, Conrotto, F, Giordana, F, Moretti, C, D'Amico, M, Salizzoni, S, Omede, P, La Torre, M, Thomas, M, Hildick-Smith, D, Ussia, G, Barbanti, M, Tamburino, C, Webb, J, Schnabel, RB, Seiffert, M, Wilde, S, Treede, H, Gasparetto, V, Napodano, M, Tarantini, G, Presbitero, P, Mennuni, M, Rossi, ML, Gasparini, M, Zoccai, GB, Lupo, M, Rinaldi, M, Gaita, F & Marra, S 2013, 'Mid-term prognostic value of coronary artery disease in patients undergoing transcatheter aortic valve implantation: A meta-analysis of adjusted observational results', International Journal of Cardiology, vol. 168, no. 3, pp. 2528-2532. https://doi.org/10.1016/j.ijcard.2013.03.062

Mid-term prognostic value of coronary artery disease in patients undergoing transcatheter aortic valve implantation: A meta-analysis of adjusted observational results. / D'Ascenzo, F.; Conrotto, F.; Giordana, F. et al.
In: International Journal of Cardiology, Vol. 168, No. 3, 03.10.2013, p. 2528-2532.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Mid-term prognostic value of coronary artery disease in patients undergoing transcatheter aortic valve implantation

T2 - A meta-analysis of adjusted observational results

AU - D'Ascenzo, F.

AU - Conrotto, F.

AU - Giordana, F.

AU - Moretti, C.

AU - D'Amico, M.

AU - Salizzoni, S.

AU - Omede, P.

AU - La Torre, M.

AU - Thomas, Martyn

AU - Hildick-Smith, D.

AU - Ussia, Gp.

AU - Barbanti, M.

AU - Tamburino, C.

AU - Webb, John

AU - Schnabel, R. B.

AU - Seiffert, M.

AU - Wilde, S.

AU - Treede, H.

AU - Gasparetto, V.

AU - Napodano, M.

AU - Tarantini, G.

AU - Presbitero, P.

AU - Mennuni, M.

AU - Rossi, M. L.

AU - Gasparini, M.

AU - Zoccai, G. Biondi

AU - Lupo, M.

AU - Rinaldi, M.

AU - Gaita, F.

AU - Marra, S.

PY - 2013/10/3

Y1 - 2013/10/3

N2 - Aims: Coronary artery disease (CAD) negatively affects prognosis in patients undergoing surgical aortic valve replacement, being currently evaluated in the most common used risk score. Our meta-analysis aims to clarify the prognostic role of CAD on mid-term survival in patients undergoing TAVI. Methods and results: Studies reporting multivariate predictors of adverse outcomes in patients undergoing TAVI were systematically searched for and pooled, when appropriate, using a random-effect method. 960 citations were first screened and finally 7 studies (2472 patients) were included. Diagnosis of CAD was reported in 52%(42-65) of patients and 1169 Edwards SAPIEN and 1303 CoreValve prostheses were implanted. After a median follow up of 452 days (357-585) 24% of patients (19-33) died, and 23 (14-32) for cardiovascular death. At pooled analysis of multivariate approach, diagnosis of coronary artery disease did not increase risk of death (OR 1.0, 95% CI, confidence interval, 0.67-1.50 I-2 0%). Conclusion: CAD does not affect mid-term TAVI outcome: this finding should be weighted to accurately evaluate risk and strategies for patients with severe aortic stenosis.

AB - Aims: Coronary artery disease (CAD) negatively affects prognosis in patients undergoing surgical aortic valve replacement, being currently evaluated in the most common used risk score. Our meta-analysis aims to clarify the prognostic role of CAD on mid-term survival in patients undergoing TAVI. Methods and results: Studies reporting multivariate predictors of adverse outcomes in patients undergoing TAVI were systematically searched for and pooled, when appropriate, using a random-effect method. 960 citations were first screened and finally 7 studies (2472 patients) were included. Diagnosis of CAD was reported in 52%(42-65) of patients and 1169 Edwards SAPIEN and 1303 CoreValve prostheses were implanted. After a median follow up of 452 days (357-585) 24% of patients (19-33) died, and 23 (14-32) for cardiovascular death. At pooled analysis of multivariate approach, diagnosis of coronary artery disease did not increase risk of death (OR 1.0, 95% CI, confidence interval, 0.67-1.50 I-2 0%). Conclusion: CAD does not affect mid-term TAVI outcome: this finding should be weighted to accurately evaluate risk and strategies for patients with severe aortic stenosis.

KW - TAVI

KW - CAD

KW - Mid-term outcomes

KW - HIGH-RISK PATIENTS

KW - SYSTEMATIC REVIEWS

KW - EJECTION FRACTION

KW - STENOSIS

KW - OUTCOMES

KW - REPLACEMENT

KW - IMPACT

KW - INTERVENTION

KW - MORTALITY

KW - REGISTRY

U2 - 10.1016/j.ijcard.2013.03.062

DO - 10.1016/j.ijcard.2013.03.062

M3 - Article

SN - 0167-5273

VL - 168

SP - 2528

EP - 2532

JO - International Journal of Cardiology

JF - International Journal of Cardiology

IS - 3

ER -

Mid-term prognostic value of coronary artery disease in patients undergoing transcatheter aortic valve implantation: A meta-analysis of adjusted observational results

Abstract

Keywords

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