Missed opportunities for preventing group B streptococcus infection

S. Vergnano; N. Embleton; A. Collinson; Esse Mason; A. Bedford Russell; P. Heath

doi:10.1136/adc.2009.160333

Missed opportunities for preventing group B streptococcus infection

S. Vergnano^*, N. Embleton, A. Collinson, Esse Mason, A. Bedford Russell, P. Heath

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

Background: Group B streptococcus (GBS) is the most common cause of early onset (EO) neonatal infection in the UK, National guidelines for its prevention were introduced in 2003. We assessed the opportunities for prevention amongst cases of EO GBS using the electronic Neonatal Infection Surveillance Network (NeonIN).

Methods: Culture proven EO GBS cases occurring between 2004 and 2007 were identified prospectively in eight neonatal units participating in NeonIN. Data concerning risk factors, intrapartum antibiotic (IAP) use and infant outcome were collected retrospectively.

Results: There were 48 cases of GBS over the 4 years (0.52/1000 live-births); 22 male, median gestation 38 weeks. The most common clinical presentation was sepsis and the GBS-attributable mortality was 6%. Risk factors were present in 67% (32) and adequate IAP was given to six of these mothers (19%). If all women with risk factors received prophylaxis, 23 cases (48%) may have been prevented.

Conclusions: Better GBS prevention strategies are required in the UK.

Original language	English
Pages (from-to)	F72-F73
Number of pages	2
Journal	Archives of Disease in Childhood Fetal and Neonatal Edition
Volume	95
Issue number	1
DOIs	https://doi.org/10.1136/adc.2009.160333
Publication status	Published - Jan 2010

Keywords

DISEASE
UK

Access to Document

10.1136/adc.2009.160333

Cite this

@article{20089fff7a6b4770b467badc6404bf51,

title = "Missed opportunities for preventing group B streptococcus infection",

abstract = "Background: Group B streptococcus (GBS) is the most common cause of early onset (EO) neonatal infection in the UK, National guidelines for its prevention were introduced in 2003. We assessed the opportunities for prevention amongst cases of EO GBS using the electronic Neonatal Infection Surveillance Network (NeonIN).Methods: Culture proven EO GBS cases occurring between 2004 and 2007 were identified prospectively in eight neonatal units participating in NeonIN. Data concerning risk factors, intrapartum antibiotic (IAP) use and infant outcome were collected retrospectively.Results: There were 48 cases of GBS over the 4 years (0.52/1000 live-births); 22 male, median gestation 38 weeks. The most common clinical presentation was sepsis and the GBS-attributable mortality was 6%. Risk factors were present in 67% (32) and adequate IAP was given to six of these mothers (19%). If all women with risk factors received prophylaxis, 23 cases (48%) may have been prevented.Conclusions: Better GBS prevention strategies are required in the UK.",

keywords = "DISEASE, UK",

author = "S. Vergnano and N. Embleton and A. Collinson and Esse Mason and Russell, {A. Bedford} and P. Heath",

year = "2010",

month = jan,

doi = "10.1136/adc.2009.160333",

language = "English",

volume = "95",

pages = "F72--F73",

journal = "Archives of Disease in Childhood Fetal and Neonatal Edition",

issn = "1359-2998",

publisher = "BMJ Publishing Group Ltd",

number = "1",

}

TY - JOUR

T1 - Missed opportunities for preventing group B streptococcus infection

AU - Vergnano, S.

AU - Embleton, N.

AU - Collinson, A.

AU - Mason, Esse

AU - Russell, A. Bedford

AU - Heath, P.

PY - 2010/1

Y1 - 2010/1

N2 - Background: Group B streptococcus (GBS) is the most common cause of early onset (EO) neonatal infection in the UK, National guidelines for its prevention were introduced in 2003. We assessed the opportunities for prevention amongst cases of EO GBS using the electronic Neonatal Infection Surveillance Network (NeonIN).Methods: Culture proven EO GBS cases occurring between 2004 and 2007 were identified prospectively in eight neonatal units participating in NeonIN. Data concerning risk factors, intrapartum antibiotic (IAP) use and infant outcome were collected retrospectively.Results: There were 48 cases of GBS over the 4 years (0.52/1000 live-births); 22 male, median gestation 38 weeks. The most common clinical presentation was sepsis and the GBS-attributable mortality was 6%. Risk factors were present in 67% (32) and adequate IAP was given to six of these mothers (19%). If all women with risk factors received prophylaxis, 23 cases (48%) may have been prevented.Conclusions: Better GBS prevention strategies are required in the UK.

AB - Background: Group B streptococcus (GBS) is the most common cause of early onset (EO) neonatal infection in the UK, National guidelines for its prevention were introduced in 2003. We assessed the opportunities for prevention amongst cases of EO GBS using the electronic Neonatal Infection Surveillance Network (NeonIN).Methods: Culture proven EO GBS cases occurring between 2004 and 2007 were identified prospectively in eight neonatal units participating in NeonIN. Data concerning risk factors, intrapartum antibiotic (IAP) use and infant outcome were collected retrospectively.Results: There were 48 cases of GBS over the 4 years (0.52/1000 live-births); 22 male, median gestation 38 weeks. The most common clinical presentation was sepsis and the GBS-attributable mortality was 6%. Risk factors were present in 67% (32) and adequate IAP was given to six of these mothers (19%). If all women with risk factors received prophylaxis, 23 cases (48%) may have been prevented.Conclusions: Better GBS prevention strategies are required in the UK.

KW - DISEASE

KW - UK

U2 - 10.1136/adc.2009.160333

DO - 10.1136/adc.2009.160333

M3 - Article

SN - 1359-2998

VL - 95

SP - F72-F73

JO - Archives of Disease in Childhood Fetal and Neonatal Edition

JF - Archives of Disease in Childhood Fetal and Neonatal Edition

IS - 1

ER -

Missed opportunities for preventing group B streptococcus infection

Abstract

Keywords

Access to Document

Fingerprint

Cite this