Modafinil augmentation therapy in unipolar and bipolar depression: a systematic review and meta-analysis of randomized controlled trials

Alexander J Goss; Muzaffer Kaser; Sergi G Costafreda; Barbara J Sahakian; Cynthia H Y Fu

doi:10.4088/JCP.13r08560

Modafinil augmentation therapy in unipolar and bipolar depression: a systematic review and meta-analysis of randomized controlled trials

Alexander J Goss, Muzaffer Kaser, Sergi G Costafreda, Barbara J Sahakian, Cynthia H Y Fu

King's College London

Research output: Contribution to journal › Article › peer-review

114 Citations (Scopus)

Abstract

Current pharmacologic treatments for a depressive episode in unipolar major depressive disorder (MDD) and bipolar depression are limited by low rates of remission. Residual symptoms include a persistent low mood and neurovegetative symptoms such as fatigue. The objective of this study was to examine the efficacy and tolerability of augmentation of first-line therapies with the novel stimulant-like agent modafinil in MDD and bipolar depression.

Original language	English
Article number	N/A
Pages (from-to)	1101-1107
Number of pages	7
Journal	PRIMARY CARE COMPANION TO THE JOURNAL OF CLINICAL PSYCHIATRY
Volume	74
Issue number	11
DOIs	https://doi.org/10.4088/JCP.13r08560
Publication status	Published - Nov 2013

Access to Document

10.4088/JCP.13r08560

Cite this

@article{0d3b702b6c054bdea137ee114607c4d0,

title = "Modafinil augmentation therapy in unipolar and bipolar depression: a systematic review and meta-analysis of randomized controlled trials",

abstract = "Current pharmacologic treatments for a depressive episode in unipolar major depressive disorder (MDD) and bipolar depression are limited by low rates of remission. Residual symptoms include a persistent low mood and neurovegetative symptoms such as fatigue. The objective of this study was to examine the efficacy and tolerability of augmentation of first-line therapies with the novel stimulant-like agent modafinil in MDD and bipolar depression.",

author = "Goss, {Alexander J} and Muzaffer Kaser and Costafreda, {Sergi G} and Sahakian, {Barbara J} and Fu, {Cynthia H Y}",

year = "2013",

month = nov,

doi = "10.4088/JCP.13r08560",

language = "English",

volume = "74",

pages = "1101--1107",

journal = "PRIMARY CARE COMPANION TO THE JOURNAL OF CLINICAL PSYCHIATRY",

issn = "1523-5998",

publisher = "Physicians Postgraduate Press Inc.",

number = "11",

}

Modafinil augmentation therapy in unipolar and bipolar depression: a systematic review and meta-analysis of randomized controlled trials. / Goss, Alexander J; Kaser, Muzaffer; Costafreda, Sergi G et al.
In: PRIMARY CARE COMPANION TO THE JOURNAL OF CLINICAL PSYCHIATRY, Vol. 74, No. 11, N/A, 11.2013, p. 1101-1107.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Modafinil augmentation therapy in unipolar and bipolar depression

T2 - a systematic review and meta-analysis of randomized controlled trials

AU - Goss, Alexander J

AU - Kaser, Muzaffer

AU - Costafreda, Sergi G

AU - Sahakian, Barbara J

AU - Fu, Cynthia H Y

PY - 2013/11

Y1 - 2013/11

N2 - Current pharmacologic treatments for a depressive episode in unipolar major depressive disorder (MDD) and bipolar depression are limited by low rates of remission. Residual symptoms include a persistent low mood and neurovegetative symptoms such as fatigue. The objective of this study was to examine the efficacy and tolerability of augmentation of first-line therapies with the novel stimulant-like agent modafinil in MDD and bipolar depression.

AB - Current pharmacologic treatments for a depressive episode in unipolar major depressive disorder (MDD) and bipolar depression are limited by low rates of remission. Residual symptoms include a persistent low mood and neurovegetative symptoms such as fatigue. The objective of this study was to examine the efficacy and tolerability of augmentation of first-line therapies with the novel stimulant-like agent modafinil in MDD and bipolar depression.

U2 - 10.4088/JCP.13r08560

DO - 10.4088/JCP.13r08560

M3 - Article

C2 - 24330897

SN - 1523-5998

VL - 74

SP - 1101

EP - 1107

JO - PRIMARY CARE COMPANION TO THE JOURNAL OF CLINICAL PSYCHIATRY

JF - PRIMARY CARE COMPANION TO THE JOURNAL OF CLINICAL PSYCHIATRY

IS - 11

M1 - N/A

ER -

Modafinil augmentation therapy in unipolar and bipolar depression: a systematic review and meta-analysis of randomized controlled trials

Abstract

Access to Document

Fingerprint

Cite this