Modelling continuous arterial blood data from mr-compatible sampler in simultenous pet-MRI experiments

Barbara Santangelo; Joel Dunn; Katherine Beck; Colm J. McGinnity; Matteo Tonietto; Federico Turkheimer; Oliver Howes; Mattia Veronese

doi:10.1109/ISBI.2019.8759202

Modelling continuous arterial blood data from mr-compatible sampler in simultenous pet-MRI experiments

Barbara Santangelo, Joel Dunn, Katherine Beck, Colm J. McGinnity, Matteo Tonietto, Federico Turkheimer, Oliver Howes, Mattia Veronese

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review

1 Citation (Scopus)

Abstract

In the context of experimental PET imaging, continuously arterial blood sampling is often performed to obtain a time-continuous description of the radiotracer blood activity following its administration. This information is important to quantify the delivery of the tracer into tissues through the kinetic modelling analysis. With the introduction of simultaneous PET-MRI scanners, a new generation of automatic blood samplers compatible with the high magnetic field of the equipment has been introduced; however, the signal-to-noise ratio (SNR) of these counters is much poorer. In this work we extend an existing pipeline of blood modelling (called 'MultiBlood') to the analysis of arterial blood data obtained from MR-compatible samplers. We show that this method can filter out the excess of noise and return blood data time-activity courses comparable with the previous generation of blood samplers.

Original language	English
Title of host publication	ISBI 2019 - 2019 IEEE International Symposium on Biomedical Imaging
Publisher	IEEE Computer Society
Pages	750-753
Number of pages	4
Volume	2019-April
ISBN (Electronic)	9781538636411
DOIs	https://doi.org/10.1109/ISBI.2019.8759202
Publication status	Published - 1 Apr 2019
Event	16th IEEE International Symposium on Biomedical Imaging, ISBI 2019 - Venice, Italy Duration: 8 Apr 2019 → 11 Apr 2019

Conference

Conference	16th IEEE International Symposium on Biomedical Imaging, ISBI 2019
Country/Territory	Italy
City	Venice
Period	8/04/2019 → 11/04/2019

Keywords

Arterial modelling
Blood sampling
Simultaneous PET-MRI

Access to Document

10.1109/ISBI.2019.8759202

Cite this

Santangelo, B., Dunn, J., Beck, K., McGinnity, C. J., Tonietto, M., Turkheimer, F., Howes, O., & Veronese, M. (2019). Modelling continuous arterial blood data from mr-compatible sampler in simultenous pet-MRI experiments. In ISBI 2019 - 2019 IEEE International Symposium on Biomedical Imaging (Vol. 2019-April, pp. 750-753). Article 8759202 IEEE Computer Society. https://doi.org/10.1109/ISBI.2019.8759202

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author = "Barbara Santangelo and Joel Dunn and Katherine Beck and McGinnity, {Colm J.} and Matteo Tonietto and Federico Turkheimer and Oliver Howes and Mattia Veronese",

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Santangelo, B , Dunn, J , Beck, K , McGinnity, CJ, Tonietto, M, Turkheimer, F , Howes, O & Veronese, M 2019, Modelling continuous arterial blood data from mr-compatible sampler in simultenous pet-MRI experiments. in ISBI 2019 - 2019 IEEE International Symposium on Biomedical Imaging. vol. 2019-April, 8759202, IEEE Computer Society, pp. 750-753, 16th IEEE International Symposium on Biomedical Imaging, ISBI 2019, Venice, Italy, 8/04/2019. https://doi.org/10.1109/ISBI.2019.8759202

Modelling continuous arterial blood data from mr-compatible sampler in simultenous pet-MRI experiments. / Santangelo, Barbara ; Dunn, Joel ; Beck, Katherine et al.
ISBI 2019 - 2019 IEEE International Symposium on Biomedical Imaging. Vol. 2019-April IEEE Computer Society, 2019. p. 750-753 8759202.

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review

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AU - Tonietto, Matteo

AU - Turkheimer, Federico

AU - Howes, Oliver

AU - Veronese, Mattia

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Modelling continuous arterial blood data from mr-compatible sampler in simultenous pet-MRI experiments

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