Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer

A. H. M. Reid; G. Attard; L. Ambroisine; G. Fisher; G. Kovacs; D. Brewer; J. Clark; P. Flohr; S. Edwards; D. M. Berney; C. S. Foster; A. Fletcher; W. L. Gerald; H. Moller; V. E. Reuter; P. T. Scardino; J. Cuzick; J. S. de Bono; C. S. Cooper

doi:10.1038/sj.bjc.6605554

Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer

A. H. M. Reid, G. Attard, L. Ambroisine, G. Fisher, G. Kovacs, D. Brewer, J. Clark, P. Flohr, S. Edwards, D. M. Berney, C. S. Foster, A. Fletcher, W. L. Gerald, H. Moller, V. E. Reuter, P. T. Scardino, J. Cuzick, J. S. de Bono, C. S. Cooper

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Abstract

BACKGROUND: The discovery of ERG/ETV1 gene rearrangements and PTEN gene loss warrants investigation in a mechanism-based prognostic classification of prostate cancer (PCa). The study objective was to evaluate the potential clinical significance and natural history of different disease categories by combining ERG/ETV1 gene rearrangements and PTEN gene loss status. METHODS: We utilised fluorescence in situ hybridisation (FISH) assays to detect PTEN gene loss and ERG/ETV1 gene rearrangements in 308 conservatively managed PCa patients with survival outcome data. RESULTS: ERG/ETV1 gene rearrangements alone and PTEN gene loss alone both failed to show a link to survival in multivariate analyses. However, there was a strong interaction between ERG/ETV1 gene rearrangements and PTEN gene loss (P

Original language	English
Pages (from-to)	678 - 684
Number of pages	7
Journal	BJC: British Journal of Cancer
Volume	102
Issue number	4
DOIs	https://doi.org/10.1038/sj.bjc.6605554
Publication status	Published - Feb 2010

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Reid, A. H. M., Attard, G., Ambroisine, L., Fisher, G., Kovacs, G., Brewer, D., Clark, J., Flohr, P., Edwards, S., Berney, D. M., Foster, C. S., Fletcher, A., Gerald, W. L., Moller, H., Reuter, V. E., Scardino, P. T., Cuzick, J., de Bono, J. S., & Cooper, C. S. (2010). Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer. BJC: British Journal of Cancer, 102(4), 678 - 684. https://doi.org/10.1038/sj.bjc.6605554

@article{a66df0aa9c6f4709b74bbcadb9156c16,

title = "Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer",

abstract = "BACKGROUND: The discovery of ERG/ETV1 gene rearrangements and PTEN gene loss warrants investigation in a mechanism-based prognostic classification of prostate cancer (PCa). The study objective was to evaluate the potential clinical significance and natural history of different disease categories by combining ERG/ETV1 gene rearrangements and PTEN gene loss status. METHODS: We utilised fluorescence in situ hybridisation (FISH) assays to detect PTEN gene loss and ERG/ETV1 gene rearrangements in 308 conservatively managed PCa patients with survival outcome data. RESULTS: ERG/ETV1 gene rearrangements alone and PTEN gene loss alone both failed to show a link to survival in multivariate analyses. However, there was a strong interaction between ERG/ETV1 gene rearrangements and PTEN gene loss (P",

author = "Reid, {A. H. M.} and G. Attard and L. Ambroisine and G. Fisher and G. Kovacs and D. Brewer and J. Clark and P. Flohr and S. Edwards and Berney, {D. M.} and Foster, {C. S.} and A. Fletcher and Gerald, {W. L.} and H. Moller and Reuter, {V. E.} and Scardino, {P. T.} and J. Cuzick and {de Bono}, {J. S.} and Cooper, {C. S.}",

year = "2010",

month = feb,

doi = "10.1038/sj.bjc.6605554",

language = "English",

volume = "102",

pages = "678 -- 684",

journal = "BJC: British Journal of Cancer",

issn = "1532-1827",

publisher = "Nature Publishing Group",

number = "4",

}

Reid, AHM, Attard, G, Ambroisine, L, Fisher, G, Kovacs, G, Brewer, D, Clark, J, Flohr, P, Edwards, S, Berney, DM, Foster, CS, Fletcher, A, Gerald, WL, Moller, H, Reuter, VE, Scardino, PT, Cuzick, J, de Bono, JS & Cooper, CS 2010, 'Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer', BJC: British Journal of Cancer, vol. 102, no. 4, pp. 678 - 684. https://doi.org/10.1038/sj.bjc.6605554

TY - JOUR

T1 - Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer

AU - Reid, A. H. M.

AU - Attard, G.

AU - Ambroisine, L.

AU - Fisher, G.

AU - Kovacs, G.

AU - Brewer, D.

AU - Clark, J.

AU - Flohr, P.

AU - Edwards, S.

AU - Berney, D. M.

AU - Foster, C. S.

AU - Fletcher, A.

AU - Gerald, W. L.

AU - Moller, H.

AU - Reuter, V. E.

AU - Scardino, P. T.

AU - Cuzick, J.

AU - de Bono, J. S.

AU - Cooper, C. S.

PY - 2010/2

Y1 - 2010/2

N2 - BACKGROUND: The discovery of ERG/ETV1 gene rearrangements and PTEN gene loss warrants investigation in a mechanism-based prognostic classification of prostate cancer (PCa). The study objective was to evaluate the potential clinical significance and natural history of different disease categories by combining ERG/ETV1 gene rearrangements and PTEN gene loss status. METHODS: We utilised fluorescence in situ hybridisation (FISH) assays to detect PTEN gene loss and ERG/ETV1 gene rearrangements in 308 conservatively managed PCa patients with survival outcome data. RESULTS: ERG/ETV1 gene rearrangements alone and PTEN gene loss alone both failed to show a link to survival in multivariate analyses. However, there was a strong interaction between ERG/ETV1 gene rearrangements and PTEN gene loss (P

AB - BACKGROUND: The discovery of ERG/ETV1 gene rearrangements and PTEN gene loss warrants investigation in a mechanism-based prognostic classification of prostate cancer (PCa). The study objective was to evaluate the potential clinical significance and natural history of different disease categories by combining ERG/ETV1 gene rearrangements and PTEN gene loss status. METHODS: We utilised fluorescence in situ hybridisation (FISH) assays to detect PTEN gene loss and ERG/ETV1 gene rearrangements in 308 conservatively managed PCa patients with survival outcome data. RESULTS: ERG/ETV1 gene rearrangements alone and PTEN gene loss alone both failed to show a link to survival in multivariate analyses. However, there was a strong interaction between ERG/ETV1 gene rearrangements and PTEN gene loss (P

U2 - 10.1038/sj.bjc.6605554

DO - 10.1038/sj.bjc.6605554

M3 - Article

SN - 1532-1827

VL - 102

SP - 678

EP - 684

JO - BJC: British Journal of Cancer

JF - BJC: British Journal of Cancer

IS - 4

ER -

Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer

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