Molecular evidence for the role of a ferric reductase in iron transport

A T McKie; G Latunde-Dada; S Miret; J A McGregor; G J Anderson; C D Vulpe; J M Wrigglesworth; R J Simpson

Molecular evidence for the role of a ferric reductase in iron transport

A T McKie, G Latunde-Dada, S Miret, J A McGregor, G J Anderson, C D Vulpe, J M Wrigglesworth, R J Simpson

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49 Citations (Scopus)

Abstract

Duodenal cytochrome b (Dcytb) is a haem protein similar to the cytochrome b561 protein family. Dcytb is highly expressed in duodenal brushborder membrane and is implicated in dietary iron absorption by reducing dietary ferric iron to the ferrous form for transport via Nramp2/DCT1 (divalent-cation transporter 1)/DMT1 (divalent metal-transporter 1). The protein is expressed in other tissues and may account for ferric reductase activity at other sites in the body.

Original language	English
Pages (from-to)	722 - 724
Number of pages	3
Journal	Biochemical Society Transactions
Volume	30
Issue number	4
Publication status	Published - Aug 2002
Event	3rd International Biometals Symposium (BIOMETALS 2002) - LONDON, ENGLAND Duration: 1 Jan 2002 → …

Cite this

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title = "Molecular evidence for the role of a ferric reductase in iron transport",

abstract = "Duodenal cytochrome b (Dcytb) is a haem protein similar to the cytochrome b561 protein family. Dcytb is highly expressed in duodenal brushborder membrane and is implicated in dietary iron absorption by reducing dietary ferric iron to the ferrous form for transport via Nramp2/DCT1 (divalent-cation transporter 1)/DMT1 (divalent metal-transporter 1). The protein is expressed in other tissues and may account for ferric reductase activity at other sites in the body.",

author = "McKie, {A T} and G Latunde-Dada and S Miret and McGregor, {J A} and Anderson, {G J} and Vulpe, {C D} and Wrigglesworth, {J M} and Simpson, {R J}",

year = "2002",

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language = "English",

volume = "30",

pages = "722 -- 724",

journal = "Biochemical Society Transactions",

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note = "3rd International Biometals Symposium (BIOMETALS 2002) ; Conference date: 01-01-2002",

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T1 - Molecular evidence for the role of a ferric reductase in iron transport

AU - McKie, A T

AU - Latunde-Dada, G

AU - Miret, S

AU - McGregor, J A

AU - Anderson, G J

AU - Vulpe, C D

AU - Wrigglesworth, J M

AU - Simpson, R J

PY - 2002/8

Y1 - 2002/8

N2 - Duodenal cytochrome b (Dcytb) is a haem protein similar to the cytochrome b561 protein family. Dcytb is highly expressed in duodenal brushborder membrane and is implicated in dietary iron absorption by reducing dietary ferric iron to the ferrous form for transport via Nramp2/DCT1 (divalent-cation transporter 1)/DMT1 (divalent metal-transporter 1). The protein is expressed in other tissues and may account for ferric reductase activity at other sites in the body.

AB - Duodenal cytochrome b (Dcytb) is a haem protein similar to the cytochrome b561 protein family. Dcytb is highly expressed in duodenal brushborder membrane and is implicated in dietary iron absorption by reducing dietary ferric iron to the ferrous form for transport via Nramp2/DCT1 (divalent-cation transporter 1)/DMT1 (divalent metal-transporter 1). The protein is expressed in other tissues and may account for ferric reductase activity at other sites in the body.

UR - http://www.scopus.com/inward/record.url?scp=0036669942&partnerID=8YFLogxK

M3 - Conference paper

SN - 1470-8752

VL - 30

SP - 722

EP - 724

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 4

T2 - 3rd International Biometals Symposium (BIOMETALS 2002)

Y2 - 1 January 2002

ER -

Molecular evidence for the role of a ferric reductase in iron transport

Abstract

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