MORPHOLOGICAL MARKERS AND DETERMINANTS OF LEFT VENTRICULAR SYSTOLIC DYSFUNCTION IN REPAIRED TETRALOGY OF FALLOT

Sachin Govil; Nickolas Forsch; Sara Salehyar; Kathleen Gilbert; Avan Suinesiaputra; Sanjeet Hegde; James C. Perry; Alistair A. Young; Jeffrey H. Omens; Andrew D. McCulloch

doi:10.1115/IMECE2021-70591

MORPHOLOGICAL MARKERS AND DETERMINANTS OF LEFT VENTRICULAR SYSTOLIC DYSFUNCTION IN REPAIRED TETRALOGY OF FALLOT

Sachin Govil^*, Nickolas Forsch, Sara Salehyar, Kathleen Gilbert, Avan Suinesiaputra, Sanjeet Hegde, James C. Perry, Alistair A. Young, Jeffrey H. Omens, Andrew D. McCulloch

^*Corresponding author for this work

Biomedical Engineering Department

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review

1 Citation (Scopus)

Abstract

Patients with repaired tetralogy of Fallot (rTOF) are at risk of long-term left ventricular (LV) dysfunction associated with poor outcomes. In this study, we examined the association of LV end-diastolic (ED) shape with components of systolic wall motion (SWM) that contribute to global systolic dysfunction in an rTOF patient cohort. Features of LV shape associated with conicity and septal wall curvature correlated with components of SWM. The effect of ED shape perturbations on SWM were examined in a finite element analysis of systolic ventricular mechanics. Variations in the combination of ED shape and myocardial contractility were able to match predicted measures of SWM. From these results, we hypothesize that greater LV conicity and a flatter septal wall are markers of reduced global myocardial contractility and should be examined further for clinical prognostic utility to improve patient outcomes.

Original language	English
Title of host publication	Biomedical and Biotechnology
Publisher	American Society of Mechanical Engineers(ASME)
ISBN (Electronic)	9780791885598
DOIs	https://doi.org/10.1115/IMECE2021-70591
Publication status	Published - 2021
Event	ASME 2021 International Mechanical Engineering Congress and Exposition, IMECE 2021 - Virtual, Online Duration: 1 Nov 2021 → 5 Nov 2021

Publication series

Name	ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
Volume	5

Conference

Conference	ASME 2021 International Mechanical Engineering Congress and Exposition, IMECE 2021
City	Virtual, Online
Period	1/11/2021 → 5/11/2021

Keywords

Biomechanics
Statistical atlas
Tetralogy of fallot

Access to Document

10.1115/IMECE2021-70591

Cite this

Govil, S., Forsch, N., Salehyar, S., Gilbert, K., Suinesiaputra, A., Hegde, S., Perry, J. C., Young, A. A., Omens, J. H., & McCulloch, A. D. (2021). MORPHOLOGICAL MARKERS AND DETERMINANTS OF LEFT VENTRICULAR SYSTOLIC DYSFUNCTION IN REPAIRED TETRALOGY OF FALLOT. In Biomedical and Biotechnology Article v005t05a033 (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE); Vol. 5). American Society of Mechanical Engineers(ASME). https://doi.org/10.1115/IMECE2021-70591

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title = "MORPHOLOGICAL MARKERS AND DETERMINANTS OF LEFT VENTRICULAR SYSTOLIC DYSFUNCTION IN REPAIRED TETRALOGY OF FALLOT",

abstract = "Patients with repaired tetralogy of Fallot (rTOF) are at risk of long-term left ventricular (LV) dysfunction associated with poor outcomes. In this study, we examined the association of LV end-diastolic (ED) shape with components of systolic wall motion (SWM) that contribute to global systolic dysfunction in an rTOF patient cohort. Features of LV shape associated with conicity and septal wall curvature correlated with components of SWM. The effect of ED shape perturbations on SWM were examined in a finite element analysis of systolic ventricular mechanics. Variations in the combination of ED shape and myocardial contractility were able to match predicted measures of SWM. From these results, we hypothesize that greater LV conicity and a flatter septal wall are markers of reduced global myocardial contractility and should be examined further for clinical prognostic utility to improve patient outcomes.",

keywords = "Biomechanics, Statistical atlas, Tetralogy of fallot",

author = "Sachin Govil and Nickolas Forsch and Sara Salehyar and Kathleen Gilbert and Avan Suinesiaputra and Sanjeet Hegde and Perry, {James C.} and Young, {Alistair A.} and Omens, {Jeffrey H.} and McCulloch, {Andrew D.}",

note = "Funding Information: Funding was provided by the National Institutes of Health (USA) R01HL121754 and AHA grant 19AIML35120034. SG acknowledges National Institutes of Health NHLBI 1T32HL105373. Publisher Copyright: Copyright copy; 2021 by ASME.; ASME 2021 International Mechanical Engineering Congress and Exposition, IMECE 2021 ; Conference date: 01-11-2021 Through 05-11-2021",

year = "2021",

doi = "10.1115/IMECE2021-70591",

language = "English",

series = "ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)",

publisher = "American Society of Mechanical Engineers(ASME)",

booktitle = "Biomedical and Biotechnology",

address = "United States",

}

Govil, S, Forsch, N, Salehyar, S, Gilbert, K, Suinesiaputra, A, Hegde, S, Perry, JC, Young, AA, Omens, JH & McCulloch, AD 2021, MORPHOLOGICAL MARKERS AND DETERMINANTS OF LEFT VENTRICULAR SYSTOLIC DYSFUNCTION IN REPAIRED TETRALOGY OF FALLOT. in Biomedical and Biotechnology., v005t05a033, ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE), vol. 5, American Society of Mechanical Engineers(ASME), ASME 2021 International Mechanical Engineering Congress and Exposition, IMECE 2021, Virtual, Online, 1/11/2021. https://doi.org/10.1115/IMECE2021-70591

MORPHOLOGICAL MARKERS AND DETERMINANTS OF LEFT VENTRICULAR SYSTOLIC DYSFUNCTION IN REPAIRED TETRALOGY OF FALLOT. / Govil, Sachin; Forsch, Nickolas; Salehyar, Sara et al.
Biomedical and Biotechnology. American Society of Mechanical Engineers(ASME), 2021. v005t05a033 (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE); Vol. 5).

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review

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T1 - MORPHOLOGICAL MARKERS AND DETERMINANTS OF LEFT VENTRICULAR SYSTOLIC DYSFUNCTION IN REPAIRED TETRALOGY OF FALLOT

AU - Govil, Sachin

AU - Forsch, Nickolas

AU - Salehyar, Sara

AU - Gilbert, Kathleen

AU - Suinesiaputra, Avan

AU - Hegde, Sanjeet

AU - Perry, James C.

AU - Young, Alistair A.

AU - Omens, Jeffrey H.

AU - McCulloch, Andrew D.

N1 - Funding Information: Funding was provided by the National Institutes of Health (USA) R01HL121754 and AHA grant 19AIML35120034. SG acknowledges National Institutes of Health NHLBI 1T32HL105373. Publisher Copyright: Copyright copy; 2021 by ASME.

PY - 2021

Y1 - 2021

N2 - Patients with repaired tetralogy of Fallot (rTOF) are at risk of long-term left ventricular (LV) dysfunction associated with poor outcomes. In this study, we examined the association of LV end-diastolic (ED) shape with components of systolic wall motion (SWM) that contribute to global systolic dysfunction in an rTOF patient cohort. Features of LV shape associated with conicity and septal wall curvature correlated with components of SWM. The effect of ED shape perturbations on SWM were examined in a finite element analysis of systolic ventricular mechanics. Variations in the combination of ED shape and myocardial contractility were able to match predicted measures of SWM. From these results, we hypothesize that greater LV conicity and a flatter septal wall are markers of reduced global myocardial contractility and should be examined further for clinical prognostic utility to improve patient outcomes.

AB - Patients with repaired tetralogy of Fallot (rTOF) are at risk of long-term left ventricular (LV) dysfunction associated with poor outcomes. In this study, we examined the association of LV end-diastolic (ED) shape with components of systolic wall motion (SWM) that contribute to global systolic dysfunction in an rTOF patient cohort. Features of LV shape associated with conicity and septal wall curvature correlated with components of SWM. The effect of ED shape perturbations on SWM were examined in a finite element analysis of systolic ventricular mechanics. Variations in the combination of ED shape and myocardial contractility were able to match predicted measures of SWM. From these results, we hypothesize that greater LV conicity and a flatter septal wall are markers of reduced global myocardial contractility and should be examined further for clinical prognostic utility to improve patient outcomes.

KW - Biomechanics

KW - Statistical atlas

KW - Tetralogy of fallot

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DO - 10.1115/IMECE2021-70591

M3 - Conference paper

AN - SCOPUS:85124425013

T3 - ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)

BT - Biomedical and Biotechnology

PB - American Society of Mechanical Engineers(ASME)

T2 - ASME 2021 International Mechanical Engineering Congress and Exposition, IMECE 2021

Y2 - 1 November 2021 through 5 November 2021

ER -

Govil S, Forsch N, Salehyar S, Gilbert K, Suinesiaputra A, Hegde S et al. MORPHOLOGICAL MARKERS AND DETERMINANTS OF LEFT VENTRICULAR SYSTOLIC DYSFUNCTION IN REPAIRED TETRALOGY OF FALLOT. In Biomedical and Biotechnology. American Society of Mechanical Engineers(ASME). 2021. v005t05a033. (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)). doi: 10.1115/IMECE2021-70591

MORPHOLOGICAL MARKERS AND DETERMINANTS OF LEFT VENTRICULAR SYSTOLIC DYSFUNCTION IN REPAIRED TETRALOGY OF FALLOT

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Keywords

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