Abstract
The potential of carbon nanotubes as carriers and delivery vectors for anticancer drugs was investigated. Herein, we propose MWNT-doxorubicin supramolecular complexes that can be developed for cancer therapy. The formation of such complexes is evidenced by a sharp decrease in the intensity of the doxorubicin fluorescence spectrum and takes place via pi-pi interactions with the MWNT backbone. In addition, the structural characteristics of the CNT-doxorubicin complexes were examined by transmission electron microscopy and showed well dispersed pluronic wrapped MWNT but clustered MWNT-doxorubicin structures. Very interestingly the doxorubicin-MWNT complexes exhibit enhanced cytotoxic activity compared to both doxorubicin alone and doxorubicin-pluronic complexes.
| Original language | English |
|---|---|
| Title of host publication | NSTI NANOTECH 2008, VOL 2, TECHNICAL PROCEEDINGS |
| Editors | M Laudon, B Romanowicz |
| Publisher | CRC PRESS-TAYLOR & FRANCIS GROUP |
| Pages | 16-18 |
| Number of pages | 3 |
| ISBN (Print) | 978-1-4200-8504-4 |
| Publication status | Published - 2008 |
| Event | Nanotechnology Conference and Trade Show (Nanotech 2008) - Boston, Morocco Duration: 1 Jun 2008 → 5 Jun 2008 |
Conference
| Conference | Nanotechnology Conference and Trade Show (Nanotech 2008) |
|---|---|
| Country/Territory | Morocco |
| Period | 1/06/2008 → 5/06/2008 |
Keywords
- carbon nanotubes
- doxorubicin
- supramolecular complexes
- cancer
- AQUEOUS-SOLUTION
- ASSOCIATION
