Mutations in the splicing factor SF3B1 are linked to frequent emergence of HLA-DR
        low/neg monocytes in lower-risk myelodysplastic neoplasms.

Susann Winter; Marie Schneider; Uta Oelschlaegel; Giulia Maggioni; Elena Riva; Marco Gabriele Raddi; Sara Bencini; Benedetta Peruzzi; Desmond Choy; Rita Antunes Dos Reis; Esther Güse; Christopher Lischer; Julio Vera; Jessica A Timms; Nicolas Sompairac; Katja Sockel; Antonella Poloni; Antje Tunger; Matteo Giovanni Della Porta; Valeria Santini; Marc Schmitz; Uwe Platzbecker; Shahram Kordasti

doi:10.1038/s41375-024-02249-z

Mutations in the splicing factor SF3B1 are linked to frequent emergence of HLA-DR low/neg monocytes in lower-risk myelodysplastic neoplasms.

Susann Winter, Marie Schneider, Uta Oelschlaegel, Giulia Maggioni, Elena Riva, Marco Gabriele Raddi, Sara Bencini, Benedetta Peruzzi, Desmond Choy, Rita Antunes Dos Reis, Esther Güse, Christopher Lischer, Julio Vera, Jessica A Timms, Nicolas Sompairac, Katja Sockel, Antonella Poloni, Antje Tunger, Matteo Giovanni Della Porta, Valeria SantiniMarc Schmitz, Uwe Platzbecker, Shahram Kordasti

Comprehensive Cancer Centre

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Original language	English
Pages (from-to)	1427-1431
Number of pages	5
Journal	Leukemia
Volume	38
Issue number	6
Early online date	17 Apr 2024
DOIs	https://doi.org/10.1038/s41375-024-02249-z https://doi.org/10.1038/s41375-024-02249-z
Publication status	Published - Jun 2024

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Winter, S., Schneider, M., Oelschlaegel, U., Maggioni, G., Riva, E., Raddi, M. G., Bencini, S., Peruzzi, B., Choy, D., Antunes Dos Reis, R., Güse, E., Lischer, C., Vera, J., Timms, J. A., Sompairac, N., Sockel, K., Poloni, A., Tunger, A., Della Porta, M. G., ... Kordasti, S. (2024). Mutations in the splicing factor SF3B1 are linked to frequent emergence of HLA-DR low/neg monocytes in lower-risk myelodysplastic neoplasms. Leukemia, 38(6), 1427-1431. https://doi.org/10.1038/s41375-024-02249-z, https://doi.org/10.1038/s41375-024-02249-z

@article{4be2bcd427244edbbb9384bc997632f1,

title = "Mutations in the splicing factor SF3B1 are linked to frequent emergence of HLA-DR low/neg monocytes in lower-risk myelodysplastic neoplasms.",

author = "Susann Winter and Marie Schneider and Uta Oelschlaegel and Giulia Maggioni and Elena Riva and Raddi, {Marco Gabriele} and Sara Bencini and Benedetta Peruzzi and Desmond Choy and {Antunes Dos Reis}, Rita and Esther G{\"u}se and Christopher Lischer and Julio Vera and Timms, {Jessica A} and Nicolas Sompairac and Katja Sockel and Antonella Poloni and Antje Tunger and {Della Porta}, {Matteo Giovanni} and Valeria Santini and Marc Schmitz and Uwe Platzbecker and Shahram Kordasti",

note = "Funding Information: We would like to thank Ivonne Habermann (University Hospital Carl Gustav Carus, Dresden, Germany) for excellent technical support and all technicians in the flow cytometry laboratories for processing samples and acquiring raw data. We would also like to thank Dr. Sebastian Stasik (Department of Internal Medicine I, University Hospital Carl Gustav Carus, Faculty of Medicine, TU Dresden, Dresden, Germany) for help with variant calling from RNA-seq data, Caroline E. Roe (Mass Cytometry Center of Excellence, Vanderbilt University, Nashville, TN, USA) for help with the T-REX pipeline, and Dr. Falk Heidenreich (Department of Internal Medicine I, University Hospital Carl Gustav Carus, Faculty of Medicine, TU Dresden) for constructive feedback and discussions. Moreover, we would like to thank Dr. J\u00F6rg Lehmann and Claudia M\u00FCller for providing and assisting with the FLEXMAP 3D\u2122 system (Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany). We also thank the King\u2019s College London research facilities and the University College London/Department of Computer Science HPC facility for support. We would also like to thank all the patients for contributing to this study. This work was supported by the transCampus funding program between King\u2019s College London and TU Dresden (UP), the DKTK partner site Dresden (UP), the European Union - Transcan 7 Horizon 2020 - EuroMDS project #20180424 (MGDP), the Next Generation EU - NRRP M6C2 - Investment 2.1 Enhancement and strengthening of biomedical research in the NHS (MGDP), and the AIRC Foundation (Associazione Italiana per la Ricerca contro il Cancro, Milan, Italy) projects #22053 (to MGDP) and #26537 (to VS). SK and RADR are supported by the CRUK City of London Centre Award [CTRQQR-2021/100004] at KCL.",

year = "2024",

month = jun,

doi = "10.1038/s41375-024-02249-z",

language = "English",

volume = "38",

pages = "1427--1431",

journal = "Leukemia",

issn = "1476-5551",

publisher = "Springer Nature [academic journals on nature.com]",

number = "6",

}

Winter, S, Schneider, M, Oelschlaegel, U, Maggioni, G, Riva, E, Raddi, MG, Bencini, S, Peruzzi, B, Choy, D , Antunes Dos Reis, R, Güse, E, Lischer, C, Vera, J, Timms, JA , Sompairac, N, Sockel, K, Poloni, A, Tunger, A, Della Porta, MG, Santini, V, Schmitz, M, Platzbecker, U & Kordasti, S 2024, 'Mutations in the splicing factor SF3B1 are linked to frequent emergence of HLA-DR low/neg monocytes in lower-risk myelodysplastic neoplasms.', Leukemia, vol. 38, no. 6, pp. 1427-1431. https://doi.org/10.1038/s41375-024-02249-z, https://doi.org/10.1038/s41375-024-02249-z

TY - JOUR

T1 - Mutations in the splicing factor SF3B1 are linked to frequent emergence of HLA-DR low/neg monocytes in lower-risk myelodysplastic neoplasms.

AU - Winter, Susann

AU - Schneider, Marie

AU - Oelschlaegel, Uta

AU - Maggioni, Giulia

AU - Riva, Elena

AU - Raddi, Marco Gabriele

AU - Bencini, Sara

AU - Peruzzi, Benedetta

AU - Choy, Desmond

AU - Antunes Dos Reis, Rita

AU - Güse, Esther

AU - Lischer, Christopher

AU - Vera, Julio

AU - Timms, Jessica A

AU - Sompairac, Nicolas

AU - Sockel, Katja

AU - Poloni, Antonella

AU - Tunger, Antje

AU - Della Porta, Matteo Giovanni

AU - Santini, Valeria

AU - Schmitz, Marc

AU - Platzbecker, Uwe

AU - Kordasti, Shahram

N1 - Funding Information: We would like to thank Ivonne Habermann (University Hospital Carl Gustav Carus, Dresden, Germany) for excellent technical support and all technicians in the flow cytometry laboratories for processing samples and acquiring raw data. We would also like to thank Dr. Sebastian Stasik (Department of Internal Medicine I, University Hospital Carl Gustav Carus, Faculty of Medicine, TU Dresden, Dresden, Germany) for help with variant calling from RNA-seq data, Caroline E. Roe (Mass Cytometry Center of Excellence, Vanderbilt University, Nashville, TN, USA) for help with the T-REX pipeline, and Dr. Falk Heidenreich (Department of Internal Medicine I, University Hospital Carl Gustav Carus, Faculty of Medicine, TU Dresden) for constructive feedback and discussions. Moreover, we would like to thank Dr. J\u00F6rg Lehmann and Claudia M\u00FCller for providing and assisting with the FLEXMAP 3D\u2122 system (Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany). We also thank the King\u2019s College London research facilities and the University College London/Department of Computer Science HPC facility for support. We would also like to thank all the patients for contributing to this study. This work was supported by the transCampus funding program between King\u2019s College London and TU Dresden (UP), the DKTK partner site Dresden (UP), the European Union - Transcan 7 Horizon 2020 - EuroMDS project #20180424 (MGDP), the Next Generation EU - NRRP M6C2 - Investment 2.1 Enhancement and strengthening of biomedical research in the NHS (MGDP), and the AIRC Foundation (Associazione Italiana per la Ricerca contro il Cancro, Milan, Italy) projects #22053 (to MGDP) and #26537 (to VS). SK and RADR are supported by the CRUK City of London Centre Award [CTRQQR-2021/100004] at KCL.

PY - 2024/6

Y1 - 2024/6

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U2 - 10.1038/s41375-024-02249-z

DO - 10.1038/s41375-024-02249-z

M3 - Article

C2 - 38632316

SN - 1476-5551

VL - 38

SP - 1427

EP - 1431

JO - Leukemia

JF - Leukemia

IS - 6

ER -

Mutations in the splicing factor SF3B1 are linked to frequent emergence of HLA-DR low/neg monocytes in lower-risk myelodysplastic neoplasms.

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