Nerve Growth Factor and Pain Mechanisms

Franziska Denk; David L. Bennett; Stephen B McMahon

doi:10.1146/annurev-neuro-072116-031121

Nerve Growth Factor and Pain Mechanisms

Franziska Denk, David L. Bennett, Stephen B McMahon

Wolfson SPaRC

Oxford University Hospitals NHS Foundation Trust

Research output: Contribution to journal › Article › peer-review

185 Citations (Scopus)

Abstract

Nerve growth factor (NGF) antagonism is on the verge of becoming a powerful analgesic treatment for numerous conditions, including osteoarthritis and lower back pain. This review summarizes the historical research, both fundamental and clinical, that led to our current understanding of NGF biology. We also discuss the surprising number of questions that remain about NGF expression patterns and NGF's various functions and interaction partners in relation to persistent pain and the potential side effects of anti-NGF therapy. Expected final online publication date for the Annual Review of Neuroscience Volume 40 is July 8, 2017. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Original language	English
Pages (from-to)	307-325
Number of pages	18
Journal	Annual Review of Neuroscience
Volume	40
Early online date	24 Apr 2017
DOIs	https://doi.org/10.1146/annurev-neuro-072116-031121
Publication status	Published - 2017

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Journal Article

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10.1146/annurev-neuro-072116-031121

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Nerve Growth Factor and Pain Mechanisms

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