New insights into eutectic cream skin penetration enhancement

Sarah Fiala; Marie Roman; Ricardo Inacio; Sumaia Mashal; Marc B. Brown; Stuart A. Jones

doi:10.1016/j.ijpharm.2015.12.059

New insights into eutectic cream skin penetration enhancement

Sarah Fiala, Marie Roman, Ricardo Inacio, Sumaia Mashal, Marc B. Brown, Stuart A. Jones^*

^*Corresponding author for this work

Institute of Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The manner in which the eutectic cream EMLA^® enhances the percutaneous penetration of lidocaine and prilocaine into human skin is still not fully understood. The purpose of this study was to investigate if the modification of drug aggregation played a role in the way EMLA^® facilitates delivery. Light scattering analysis of lidocaine alone in water gave a critical aggregation concentration (CAC) of 572 μM and a mean aggregate size of 58.8 nm. The analysis of prilocaine in identical conditions gave a CAC of 1177 μM and a mean aggregate size of 105.7 ± 24.8 nm. When the two drugs were mixed at their eutectic 1:1 ratio in water the CAC reduced to 165.8 μM and the aggregate size was 43.82 nm. This lidocaine-prilocaine interaction in water was further modified upon addition of polyoxyethylene hydrogenated castor oil, the surfactant in the EMLA aqueous phase, to produce aggregates of

Original language	English
Pages (from-to)	403-411
Number of pages	9
Journal	INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume	499
Issue number	1-2
DOIs	https://doi.org/10.1016/j.ijpharm.2015.12.059
Publication status	Published - 29 Feb 2016

Keywords

EMLA
Eutectic
Lidocaine
Penetration enhancement
Prilocaine
Skin

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10.1016/j.ijpharm.2015.12.059

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title = "New insights into eutectic cream skin penetration enhancement",

abstract = "The manner in which the eutectic cream EMLA{\textregistered} enhances the percutaneous penetration of lidocaine and prilocaine into human skin is still not fully understood. The purpose of this study was to investigate if the modification of drug aggregation played a role in the way EMLA{\textregistered} facilitates delivery. Light scattering analysis of lidocaine alone in water gave a critical aggregation concentration (CAC) of 572 μM and a mean aggregate size of 58.8 nm. The analysis of prilocaine in identical conditions gave a CAC of 1177 μM and a mean aggregate size of 105.7 ± 24.8 nm. When the two drugs were mixed at their eutectic 1:1 ratio in water the CAC reduced to 165.8 μM and the aggregate size was 43.82 nm. This lidocaine-prilocaine interaction in water was further modified upon addition of polyoxyethylene hydrogenated castor oil, the surfactant in the EMLA aqueous phase, to produce aggregates of ",

keywords = "EMLA, Eutectic, Lidocaine, Penetration enhancement, Prilocaine, Skin",

author = "Sarah Fiala and Marie Roman and Ricardo Inacio and Sumaia Mashal and Brown, {Marc B.} and Jones, {Stuart A.}",

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T1 - New insights into eutectic cream skin penetration enhancement

AU - Fiala, Sarah

AU - Roman, Marie

AU - Inacio, Ricardo

AU - Mashal, Sumaia

AU - Brown, Marc B.

AU - Jones, Stuart A.

PY - 2016/2/29

Y1 - 2016/2/29

N2 - The manner in which the eutectic cream EMLA® enhances the percutaneous penetration of lidocaine and prilocaine into human skin is still not fully understood. The purpose of this study was to investigate if the modification of drug aggregation played a role in the way EMLA® facilitates delivery. Light scattering analysis of lidocaine alone in water gave a critical aggregation concentration (CAC) of 572 μM and a mean aggregate size of 58.8 nm. The analysis of prilocaine in identical conditions gave a CAC of 1177 μM and a mean aggregate size of 105.7 ± 24.8 nm. When the two drugs were mixed at their eutectic 1:1 ratio in water the CAC reduced to 165.8 μM and the aggregate size was 43.82 nm. This lidocaine-prilocaine interaction in water was further modified upon addition of polyoxyethylene hydrogenated castor oil, the surfactant in the EMLA aqueous phase, to produce aggregates of

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KW - EMLA

KW - Eutectic

KW - Lidocaine

KW - Penetration enhancement

KW - Prilocaine

KW - Skin

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JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS

IS - 1-2

ER -

New insights into eutectic cream skin penetration enhancement

Abstract

Keywords

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