TY - JOUR
T1 - New tests to detect antiphospholipid antibodies
T2 - antiprothrombin (aPT) and anti-phosphatidylserine/prothrombin (aPS/PT) antibodies
AU - Sciascia, Savino
AU - Khamashta, Munther A
AU - Bertolaccini, Maria Laura
PY - 2014/5
Y1 - 2014/5
N2 - Antiprothrombin antibodies have been proposed as potential new biomarkers for thrombosis and/or pregnancy morbidity in the setting of the antiphospholipid syndrome (APS). Antiprothrombin antibodies are commonly detected by ELISA, using prothrombin coated onto irradiated plates (aPT), or prothrombin in complex with phosphatidylserine (aPS/PT), as antigen. Although these antibodies can co-exist in the same patient, aPT and aPS/PT seem to belong to different populations of autoantibodies. Early research explored the role of antibodies to prothrombin as potential antigenic targets for the lupus anticoagulant (LA). To date their clinical significance is being investigated and their potential role in identifying patients at higher risk of developing thrombotic events or pregnancy morbidity is being probed.
AB - Antiprothrombin antibodies have been proposed as potential new biomarkers for thrombosis and/or pregnancy morbidity in the setting of the antiphospholipid syndrome (APS). Antiprothrombin antibodies are commonly detected by ELISA, using prothrombin coated onto irradiated plates (aPT), or prothrombin in complex with phosphatidylserine (aPS/PT), as antigen. Although these antibodies can co-exist in the same patient, aPT and aPS/PT seem to belong to different populations of autoantibodies. Early research explored the role of antibodies to prothrombin as potential antigenic targets for the lupus anticoagulant (LA). To date their clinical significance is being investigated and their potential role in identifying patients at higher risk of developing thrombotic events or pregnancy morbidity is being probed.
U2 - 10.1007/s11926-014-0415-x
DO - 10.1007/s11926-014-0415-x
M3 - Article
C2 - 24609824
SN - 1523-3774
VL - 16
JO - Current Rheumatology Reports
JF - Current Rheumatology Reports
IS - 5
M1 - 415
ER -