No evidence that extended tracts of homozygosity are associated with Alzheimer's disease

Rebecca Sims; Sarah Dwyer; Denise Harold; Amy Gerrish; Paul Hollingworth; Jade Chapman; Nicola Jones; Richard Abraham; Dobril Ivanov; Jaspreet Singh Pahwa; Valentina Moskvina; Kimberley Dowzell; Charlene Thomas; Alexandra Stretton; Simon Lovestone; John Powell; Petroula Proitsi; Michelle K Lupton; Carol Brayne; David C Rubinsztein; Michael Gill; Brian Lawlor; Aoibhinn Lynch; Kevin Morgan; Kristelle S Brown; Peter A Passmore; David Craig; Bernadette McGuiness; Stephen Todd; Janet A Johnston; Clive Holmes; David Mann; A David Smith; Seth Love; Patrick G Kehoe; John Hardy; Simon Mead; Nick Fox; Martin Rossor; John Collinge; Gill Livingston; Nicholas J Bass; Hugh Gurling; Andrew McQuillin; Lesley Jones; Peter A Holmans; Michael O'Donovan; Michael J Owen; Julie Williams

doi:10.1002/ajmg.b.31216

No evidence that extended tracts of homozygosity are associated with Alzheimer's disease

Rebecca Sims, Sarah Dwyer, Denise Harold, Amy Gerrish, Paul Hollingworth, Jade Chapman, Nicola Jones, Richard Abraham, Dobril Ivanov, Jaspreet Singh Pahwa, Valentina Moskvina, Kimberley Dowzell, Charlene Thomas, Alexandra Stretton, Simon Lovestone, John Powell, Petroula Proitsi, Michelle K Lupton, Carol Brayne, David C RubinszteinMichael Gill, Brian Lawlor, Aoibhinn Lynch, Kevin Morgan, Kristelle S Brown, Peter A Passmore, David Craig, Bernadette McGuiness, Stephen Todd, Janet A Johnston, Clive Holmes, David Mann, A David Smith, Seth Love, Patrick G Kehoe, John Hardy, Simon Mead, Nick Fox, Martin Rossor, John Collinge, Gill Livingston, Nicholas J Bass, Hugh Gurling, Andrew McQuillin, Lesley Jones, Peter A Holmans, Michael O'Donovan, Michael J Owen, Julie Williams

MRC Centre for Neuropyschiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University, Heath Park. [email protected]

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

We sought to investigate the contribution of extended runs of homozygosity in a genome-wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited from a common ancestor and could reflect disease loci if observed more frequently in cases than controls. We found no excess of homozygous tracts in Alzheimer's disease cases compared to controls and no individual run of homozygosity showed association to Alzheimer's disease.

Original language	English
Pages (from-to)	764-71
Number of pages	8
Journal	American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
Volume	156B
Issue number	7
DOIs	https://doi.org/10.1002/ajmg.b.31216
Publication status	Published - Dec 2011

Keywords

Aged
Aged, 80 and over
Alzheimer Disease
Case-Control Studies
Chromosomes, Human, Pair 8
Female
Genes
Genetic Predisposition to Disease
Genome-Wide Association Study
Homozygote
Humans
Male
Journal Article
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ajmg.b.31216

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Sims, R., Dwyer, S., Harold, D., Gerrish, A., Hollingworth, P., Chapman, J., Jones, N., Abraham, R., Ivanov, D., Pahwa, J. S., Moskvina, V., Dowzell, K., Thomas, C., Stretton, A., Lovestone, S., Powell, J., Proitsi, P., Lupton, M. K., Brayne, C., ... Williams, J. (2011). No evidence that extended tracts of homozygosity are associated with Alzheimer's disease. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 156B(7), 764-71. https://doi.org/10.1002/ajmg.b.31216

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title = "No evidence that extended tracts of homozygosity are associated with Alzheimer's disease",

abstract = "We sought to investigate the contribution of extended runs of homozygosity in a genome-wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited from a common ancestor and could reflect disease loci if observed more frequently in cases than controls. We found no excess of homozygous tracts in Alzheimer's disease cases compared to controls and no individual run of homozygosity showed association to Alzheimer's disease.",

keywords = "Aged, Aged, 80 and over, Alzheimer Disease, Case-Control Studies, Chromosomes, Human, Pair 8, Female, Genes, Genetic Predisposition to Disease, Genome-Wide Association Study, Homozygote, Humans, Male, Journal Article, Research Support, Non-U.S. Gov't",

author = "Rebecca Sims and Sarah Dwyer and Denise Harold and Amy Gerrish and Paul Hollingworth and Jade Chapman and Nicola Jones and Richard Abraham and Dobril Ivanov and Pahwa, {Jaspreet Singh} and Valentina Moskvina and Kimberley Dowzell and Charlene Thomas and Alexandra Stretton and Simon Lovestone and John Powell and Petroula Proitsi and Lupton, {Michelle K} and Carol Brayne and Rubinsztein, {David C} and Michael Gill and Brian Lawlor and Aoibhinn Lynch and Kevin Morgan and Brown, {Kristelle S} and Passmore, {Peter A} and David Craig and Bernadette McGuiness and Stephen Todd and Johnston, {Janet A} and Clive Holmes and David Mann and Smith, {A David} and Seth Love and Kehoe, {Patrick G} and John Hardy and Simon Mead and Nick Fox and Martin Rossor and John Collinge and Gill Livingston and Bass, {Nicholas J} and Hugh Gurling and Andrew McQuillin and Lesley Jones and Holmans, {Peter A} and Michael O'Donovan and Owen, {Michael J} and Julie Williams",

note = "Copyright {\textcopyright} 2011 Wiley-Liss, Inc.",

year = "2011",

month = dec,

doi = "10.1002/ajmg.b.31216",

language = "English",

volume = "156B",

pages = "764--71",

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Sims, R, Dwyer, S, Harold, D, Gerrish, A, Hollingworth, P, Chapman, J, Jones, N, Abraham, R, Ivanov, D, Pahwa, JS, Moskvina, V, Dowzell, K, Thomas, C, Stretton, A, Lovestone, S , Powell, J , Proitsi, P , Lupton, MK, Brayne, C, Rubinsztein, DC, Gill, M, Lawlor, B, Lynch, A, Morgan, K, Brown, KS, Passmore, PA, Craig, D, McGuiness, B, Todd, S, Johnston, JA, Holmes, C, Mann, D, Smith, AD, Love, S, Kehoe, PG, Hardy, J, Mead, S, Fox, N, Rossor, M, Collinge, J, Livingston, G, Bass, NJ, Gurling, H, McQuillin, A, Jones, L, Holmans, PA, O'Donovan, M, Owen, MJ & Williams, J 2011, 'No evidence that extended tracts of homozygosity are associated with Alzheimer's disease', American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, vol. 156B, no. 7, pp. 764-71. https://doi.org/10.1002/ajmg.b.31216

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AU - Sims, Rebecca

AU - Dwyer, Sarah

AU - Harold, Denise

AU - Gerrish, Amy

AU - Hollingworth, Paul

AU - Chapman, Jade

AU - Jones, Nicola

AU - Abraham, Richard

AU - Ivanov, Dobril

AU - Pahwa, Jaspreet Singh

AU - Moskvina, Valentina

AU - Dowzell, Kimberley

AU - Thomas, Charlene

AU - Stretton, Alexandra

AU - Lovestone, Simon

AU - Powell, John

AU - Proitsi, Petroula

AU - Lupton, Michelle K

AU - Brayne, Carol

AU - Rubinsztein, David C

AU - Gill, Michael

AU - Lawlor, Brian

AU - Lynch, Aoibhinn

AU - Morgan, Kevin

AU - Brown, Kristelle S

AU - Passmore, Peter A

AU - Craig, David

AU - McGuiness, Bernadette

AU - Todd, Stephen

AU - Johnston, Janet A

AU - Holmes, Clive

AU - Mann, David

AU - Smith, A David

AU - Love, Seth

AU - Kehoe, Patrick G

AU - Hardy, John

AU - Mead, Simon

AU - Fox, Nick

AU - Rossor, Martin

AU - Collinge, John

AU - Livingston, Gill

AU - Bass, Nicholas J

AU - Gurling, Hugh

AU - McQuillin, Andrew

AU - Jones, Lesley

AU - Holmans, Peter A

AU - O'Donovan, Michael

AU - Owen, Michael J

AU - Williams, Julie

PY - 2011/12

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N2 - We sought to investigate the contribution of extended runs of homozygosity in a genome-wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited from a common ancestor and could reflect disease loci if observed more frequently in cases than controls. We found no excess of homozygous tracts in Alzheimer's disease cases compared to controls and no individual run of homozygosity showed association to Alzheimer's disease.

AB - We sought to investigate the contribution of extended runs of homozygosity in a genome-wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited from a common ancestor and could reflect disease loci if observed more frequently in cases than controls. We found no excess of homozygous tracts in Alzheimer's disease cases compared to controls and no individual run of homozygosity showed association to Alzheimer's disease.

KW - Aged

KW - Aged, 80 and over

KW - Alzheimer Disease

KW - Case-Control Studies

KW - Chromosomes, Human, Pair 8

KW - Female

KW - Genes

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Homozygote

KW - Humans

KW - Male

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1002/ajmg.b.31216

DO - 10.1002/ajmg.b.31216

M3 - Article

C2 - 21812096

SN - 1552-4841

VL - 156B

SP - 764

EP - 771

JO - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

IS - 7

ER -

No evidence that extended tracts of homozygosity are associated with Alzheimer's disease

Abstract

Keywords

UN SDGs

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