No NRG1 V266L in Chinese patients with schizophrenia

Maria-Merce Garcia-Barcelo; Xiaoping Miao; Clara S. Tang; Hon-Cheong So; Waikiu Tang; Thomas Y. Y. Leon; Manting So; Benjamin Yip; Ronald Y. L. Chen; Eric F. C. Cheung; Eric Y. H. Chen; Tao Li; Paul Tam; Stacey S. Cherny; Pak C. Sham

doi:10.1097/YPG.0b013e328341355b

No NRG1 V266L in Chinese patients with schizophrenia

Maria-Merce Garcia-Barcelo, Xiaoping Miao, Clara S. Tang, Hon-Cheong So, Waikiu Tang, Thomas Y. Y. Leon, Manting So, Benjamin Yip, Ronald Y. L. Chen, Eric F. C. Cheung, Eric Y. H. Chen, Tao Li, Paul Tam, Stacey S. Cherny, Pak C. Sham

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

NRG1 is one of the best-supported schizophrenia (SZ) susceptibility genes. A NRG1 V266L missense mutation has been found to be associated with SZ in several populations. V266L is not in linkage disequilibrium with any of the SZ-associated NRG1 haplotypes described thus far, and may represent an independent SZ susceptibility locus within NRG1 gene. V266 is a highly conserved residue and its substitution is predicted to have a deleterious effect on the protein. As there are no data for V266L in Chinese, and given the potential relevance of this mutation, we investigated the V266L prevalence in 270 Chinese patients with schizophrenia and 270 ethnically matched controls. V266L was found neither in patients nor in controls. Lack of replication of an association across populations may be because of the differences in linkage disequilibrium structure or allele frequencies. Some true associations may not be replicated regardless of the sample size of the study. Psychiatr Genet 21:47-49 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

Original language	English
Pages (from-to)	47 - 49
Number of pages	3
Journal	Psychiatric Genetics
Volume	21
Issue number	1
DOIs	https://doi.org/10.1097/YPG.0b013e328341355b
Publication status	Published - Feb 2011

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@article{7b4350c4aeb849c79c1f6c52a31a0f49,

title = "No NRG1 V266L in Chinese patients with schizophrenia",

abstract = "NRG1 is one of the best-supported schizophrenia (SZ) susceptibility genes. A NRG1 V266L missense mutation has been found to be associated with SZ in several populations. V266L is not in linkage disequilibrium with any of the SZ-associated NRG1 haplotypes described thus far, and may represent an independent SZ susceptibility locus within NRG1 gene. V266 is a highly conserved residue and its substitution is predicted to have a deleterious effect on the protein. As there are no data for V266L in Chinese, and given the potential relevance of this mutation, we investigated the V266L prevalence in 270 Chinese patients with schizophrenia and 270 ethnically matched controls. V266L was found neither in patients nor in controls. Lack of replication of an association across populations may be because of the differences in linkage disequilibrium structure or allele frequencies. Some true associations may not be replicated regardless of the sample size of the study. Psychiatr Genet 21:47-49 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.",

author = "Maria-Merce Garcia-Barcelo and Xiaoping Miao and Tang, {Clara S.} and Hon-Cheong So and Waikiu Tang and Leon, {Thomas Y. Y.} and Manting So and Benjamin Yip and Chen, {Ronald Y. L.} and Cheung, {Eric F. C.} and Chen, {Eric Y. H.} and Tao Li and Paul Tam and Cherny, {Stacey S.} and Sham, {Pak C.}",

year = "2011",

month = feb,

doi = "10.1097/YPG.0b013e328341355b",

language = "English",

volume = "21",

pages = "47 -- 49",

journal = "Psychiatric Genetics",

publisher = "LIPPINCOTT WILLIAMS & WILKINS",

number = "1",

}

TY - JOUR

T1 - No NRG1 V266L in Chinese patients with schizophrenia

AU - Garcia-Barcelo, Maria-Merce

AU - Miao, Xiaoping

AU - Tang, Clara S.

AU - So, Hon-Cheong

AU - Tang, Waikiu

AU - Leon, Thomas Y. Y.

AU - So, Manting

AU - Yip, Benjamin

AU - Chen, Ronald Y. L.

AU - Cheung, Eric F. C.

AU - Chen, Eric Y. H.

AU - Li, Tao

AU - Tam, Paul

AU - Cherny, Stacey S.

AU - Sham, Pak C.

PY - 2011/2

Y1 - 2011/2

N2 - NRG1 is one of the best-supported schizophrenia (SZ) susceptibility genes. A NRG1 V266L missense mutation has been found to be associated with SZ in several populations. V266L is not in linkage disequilibrium with any of the SZ-associated NRG1 haplotypes described thus far, and may represent an independent SZ susceptibility locus within NRG1 gene. V266 is a highly conserved residue and its substitution is predicted to have a deleterious effect on the protein. As there are no data for V266L in Chinese, and given the potential relevance of this mutation, we investigated the V266L prevalence in 270 Chinese patients with schizophrenia and 270 ethnically matched controls. V266L was found neither in patients nor in controls. Lack of replication of an association across populations may be because of the differences in linkage disequilibrium structure or allele frequencies. Some true associations may not be replicated regardless of the sample size of the study. Psychiatr Genet 21:47-49 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

AB - NRG1 is one of the best-supported schizophrenia (SZ) susceptibility genes. A NRG1 V266L missense mutation has been found to be associated with SZ in several populations. V266L is not in linkage disequilibrium with any of the SZ-associated NRG1 haplotypes described thus far, and may represent an independent SZ susceptibility locus within NRG1 gene. V266 is a highly conserved residue and its substitution is predicted to have a deleterious effect on the protein. As there are no data for V266L in Chinese, and given the potential relevance of this mutation, we investigated the V266L prevalence in 270 Chinese patients with schizophrenia and 270 ethnically matched controls. V266L was found neither in patients nor in controls. Lack of replication of an association across populations may be because of the differences in linkage disequilibrium structure or allele frequencies. Some true associations may not be replicated regardless of the sample size of the study. Psychiatr Genet 21:47-49 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

U2 - 10.1097/YPG.0b013e328341355b

DO - 10.1097/YPG.0b013e328341355b

M3 - Article

VL - 21

SP - 47

EP - 49

JO - Psychiatric Genetics

JF - Psychiatric Genetics

IS - 1

ER -

No NRG1 V266L in Chinese patients with schizophrenia

Abstract

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