Nocturnal Oxygen Desaturation and Disordered Sleep as a Potential Factor in Executive Dysfunction in Sickle Cell Anemia

Matthew J. Hollocks; Tessa B. Kok; Fenella J. Kirkham; Johanna Gavlak; Baba Inusa; Michael R. DeBaun; Michelle de Haan

doi:10.1017/S1355617711001469

Nocturnal Oxygen Desaturation and Disordered Sleep as a Potential Factor in Executive Dysfunction in Sickle Cell Anemia

Matthew J. Hollocks^*, Tessa B. Kok, Fenella J. Kirkham, Johanna Gavlak, Baba Inusa, Michael R. DeBaun, Michelle de Haan

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

Abstract

Previous research has identified cognitive impairment in children with sickle cell anemia (SCA, Hemoglobin SS) compared with controls, partly accounted for by overt neuropathology after clinical stroke, "covert" ("silent") infarction, and severity of anemia. However, cognitive deficits have also been identified in children with SCA with no history of stroke and a normal T2-weighted magnetic resonance imaging (MRI) scan. Our aim was to investigate whether nocturnal hemoglobin oxygen desaturation and sleep fragmentation could be associated with cognitive impairment in children with SCA. We assessed 10 children with SCA (9 with normal MRI) using neuropsychological measures of executive function. Cognitive assessment was immediately followed by overnight polysomnography to record nocturnal hemoglobin oxygen saturation and sleep arousals. Decreases in hemoglobin oxygen saturation and/or increased sleep arousals were associated with reduced performance on cognitive assessment. Nocturnal hemoglobin oxygen desaturation and sleep fragmentation may be a contributing factor to executive dysfunction in SCA.

Original language	English
Pages (from-to)	168-173
Number of pages	6
Journal	Journal of the International Neuropsychological Society
Volume	18
Issue number	1
DOIs	https://doi.org/10.1017/S1355617711001469
Publication status	Published - Jan 2012

Keywords

Anemia
Sickle cell
Intelligence
Neuropsychology
Oximetry
Sleep arousal disorders
Polysomnography
PREFRONTAL CORTEX
DISEASE
CHILDREN
ADOLESCENTS
DEFICITS
VALUES

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title = "Nocturnal Oxygen Desaturation and Disordered Sleep as a Potential Factor in Executive Dysfunction in Sickle Cell Anemia",

abstract = "Previous research has identified cognitive impairment in children with sickle cell anemia (SCA, Hemoglobin SS) compared with controls, partly accounted for by overt neuropathology after clinical stroke, {"}covert{"} ({"}silent{"}) infarction, and severity of anemia. However, cognitive deficits have also been identified in children with SCA with no history of stroke and a normal T2-weighted magnetic resonance imaging (MRI) scan. Our aim was to investigate whether nocturnal hemoglobin oxygen desaturation and sleep fragmentation could be associated with cognitive impairment in children with SCA. We assessed 10 children with SCA (9 with normal MRI) using neuropsychological measures of executive function. Cognitive assessment was immediately followed by overnight polysomnography to record nocturnal hemoglobin oxygen saturation and sleep arousals. Decreases in hemoglobin oxygen saturation and/or increased sleep arousals were associated with reduced performance on cognitive assessment. Nocturnal hemoglobin oxygen desaturation and sleep fragmentation may be a contributing factor to executive dysfunction in SCA.",

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author = "Hollocks, {Matthew J.} and Kok, {Tessa B.} and Kirkham, {Fenella J.} and Johanna Gavlak and Baba Inusa and DeBaun, {Michael R.} and {de Haan}, Michelle",

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AU - Kirkham, Fenella J.

AU - Gavlak, Johanna

AU - Inusa, Baba

AU - DeBaun, Michael R.

AU - de Haan, Michelle

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AB - Previous research has identified cognitive impairment in children with sickle cell anemia (SCA, Hemoglobin SS) compared with controls, partly accounted for by overt neuropathology after clinical stroke, "covert" ("silent") infarction, and severity of anemia. However, cognitive deficits have also been identified in children with SCA with no history of stroke and a normal T2-weighted magnetic resonance imaging (MRI) scan. Our aim was to investigate whether nocturnal hemoglobin oxygen desaturation and sleep fragmentation could be associated with cognitive impairment in children with SCA. We assessed 10 children with SCA (9 with normal MRI) using neuropsychological measures of executive function. Cognitive assessment was immediately followed by overnight polysomnography to record nocturnal hemoglobin oxygen saturation and sleep arousals. Decreases in hemoglobin oxygen saturation and/or increased sleep arousals were associated with reduced performance on cognitive assessment. Nocturnal hemoglobin oxygen desaturation and sleep fragmentation may be a contributing factor to executive dysfunction in SCA.

KW - Anemia

KW - Sickle cell

KW - Intelligence

KW - Neuropsychology

KW - Oximetry

KW - Sleep arousal disorders

KW - Polysomnography

KW - PREFRONTAL CORTEX

KW - DISEASE

KW - CHILDREN

KW - ADOLESCENTS

KW - DEFICITS

KW - VALUES

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DO - 10.1017/S1355617711001469

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JO - Journal of the International Neuropsychological Society

JF - Journal of the International Neuropsychological Society

IS - 1

ER -

Nocturnal Oxygen Desaturation and Disordered Sleep as a Potential Factor in Executive Dysfunction in Sickle Cell Anemia

Abstract

Keywords

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