Oral epithelial dysplasia: Recognition, grading and clinical significance

Edward Odell; Omar Kujan; Saman Warnakulasuriya; Philip Sloan

doi:10.1111/odi.13993

Oral epithelial dysplasia: Recognition, grading and clinical significance

Edward Odell, Omar Kujan^*, Saman Warnakulasuriya, Philip Sloan

^*Corresponding author for this work

King's College London

Research output: Contribution to journal › Article › peer-review

105 Citations (Scopus)

Abstract

Histopathological grading of epithelial dysplasia remains the principal laboratory method for assessing the risk of malignant transformation in oral potentially malignant disorders (OPMDs). Current views on the molecular pathogenesis and histological interpretation of the features of epithelial dysplasia are described, and the use of grading systems for epithelial dysplasia is discussed. Changes to the current 2017 WHO criteria for diagnosis are proposed with emphasis on the architectural features of epithelial dysplasia. The predictive values of three-grade and binary systems are summarised, and categories of epithelial dysplasia are reviewed, including lichenoid and verrucous lesions, keratosis of unknown significance, HPV-associated dysplasia, differentiated and basaloid epithelial dysplasia. The implications of finding epithelial dysplasia in an oral biopsy for clinical management are discussed from the pathologists' viewpoint.

Original language	English
Pages (from-to)	1947-1976
Number of pages	30
Journal	Oral Diseases
Volume	27
Issue number	8
Early online date	14 Sept 2021
DOIs	https://doi.org/10.1111/odi.13993
Publication status	Published - Nov 2021

Keywords

dysplasia
grading systems
HPV
malignant transformation
oral cancer
oral potentially malignant disorders
pre-cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/odi.13993

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title = "Oral epithelial dysplasia: Recognition, grading and clinical significance",

abstract = "Histopathological grading of epithelial dysplasia remains the principal laboratory method for assessing the risk of malignant transformation in oral potentially malignant disorders (OPMDs). Current views on the molecular pathogenesis and histological interpretation of the features of epithelial dysplasia are described, and the use of grading systems for epithelial dysplasia is discussed. Changes to the current 2017 WHO criteria for diagnosis are proposed with emphasis on the architectural features of epithelial dysplasia. The predictive values of three-grade and binary systems are summarised, and categories of epithelial dysplasia are reviewed, including lichenoid and verrucous lesions, keratosis of unknown significance, HPV-associated dysplasia, differentiated and basaloid epithelial dysplasia. The implications of finding epithelial dysplasia in an oral biopsy for clinical management are discussed from the pathologists' viewpoint.",

keywords = "dysplasia, grading systems, HPV, malignant transformation, oral cancer, oral potentially malignant disorders, pre-cancer",

author = "Edward Odell and Omar Kujan and Saman Warnakulasuriya and Philip Sloan",

note = "Funding Information: The authors participated in the Expert Symposium on Oral Potentially Malignant Disorders held by the WHO Collaborating Centre (UK) in March 2020. We thank the Royal College of Physicians and Surgeons (RCPSG) for providing logistic support for this symposium and Henry Schein Cares for an educational grant for travel expenses to some attendees. Since the topics covered in this paper were not agreed in detail at the symposium, this is not a consensus document and has no official WHO status. It reflects the views of the authors, though we thank Professors NW Johnson, JM Aguirre-Urizar, L Monteiro, G Ogden and other symposium members for their input and constructive criticism during and after the meeting. Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC",

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doi = "10.1111/odi.13993",

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AU - Warnakulasuriya, Saman

AU - Sloan, Philip

N1 - Funding Information: The authors participated in the Expert Symposium on Oral Potentially Malignant Disorders held by the WHO Collaborating Centre (UK) in March 2020. We thank the Royal College of Physicians and Surgeons (RCPSG) for providing logistic support for this symposium and Henry Schein Cares for an educational grant for travel expenses to some attendees. Since the topics covered in this paper were not agreed in detail at the symposium, this is not a consensus document and has no official WHO status. It reflects the views of the authors, though we thank Professors NW Johnson, JM Aguirre-Urizar, L Monteiro, G Ogden and other symposium members for their input and constructive criticism during and after the meeting. Publisher Copyright: © 2021 Wiley Periodicals LLC

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AB - Histopathological grading of epithelial dysplasia remains the principal laboratory method for assessing the risk of malignant transformation in oral potentially malignant disorders (OPMDs). Current views on the molecular pathogenesis and histological interpretation of the features of epithelial dysplasia are described, and the use of grading systems for epithelial dysplasia is discussed. Changes to the current 2017 WHO criteria for diagnosis are proposed with emphasis on the architectural features of epithelial dysplasia. The predictive values of three-grade and binary systems are summarised, and categories of epithelial dysplasia are reviewed, including lichenoid and verrucous lesions, keratosis of unknown significance, HPV-associated dysplasia, differentiated and basaloid epithelial dysplasia. The implications of finding epithelial dysplasia in an oral biopsy for clinical management are discussed from the pathologists' viewpoint.

KW - dysplasia

KW - grading systems

KW - HPV

KW - malignant transformation

KW - oral cancer

KW - oral potentially malignant disorders

KW - pre-cancer

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JO - Oral Diseases

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ER -

Oral epithelial dysplasia: Recognition, grading and clinical significance

Abstract

Keywords

UN SDGs

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