Orthogonal 18F and 64Cu labelling of functionalised bis(thiosemicarbazonato) complexes

Laurence Carroll; Romain Bejot; Rebekka Hueting; Robert King; Paul Bonnitcha; Simon Bayly; Martin Christlieb; Jonathan R Dilworth; Antony D Gee; Jérôme Declerck; Véronique Gouverneur

doi:10.1039/b926980k

Orthogonal 18F and 64Cu labelling of functionalised bis(thiosemicarbazonato) complexes

Laurence Carroll, Romain Bejot, Rebekka Hueting, Robert King, Paul Bonnitcha, Simon Bayly, Martin Christlieb, Jonathan R Dilworth, Antony D Gee, Jérôme Declerck, Véronique Gouverneur

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Abstract

The synthesis of three pairs of orthogonally labelled fluorinated Cu bis(thiosemicarbazonato) complexes is presented. These are the first examples of (18)F-labelled Cu(II)-complexes designed to serve as new hypoxia selective PET tracers and as mechanistic probes to study the mode of action of this class of markers. In vitro evaluation revealed that the fluorinated Cu-complex derived from amide coupling is suitable for in vivo work.

Original language	English
Pages (from-to)	4052-4
Number of pages	3
Journal	Chemical communications (Cambridge, England)
Volume	46
Issue number	23
DOIs	https://doi.org/10.1039/b926980k
Publication status	Published - 2010

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title = "Orthogonal 18F and 64Cu labelling of functionalised bis(thiosemicarbazonato) complexes",

abstract = "The synthesis of three pairs of orthogonally labelled fluorinated Cu bis(thiosemicarbazonato) complexes is presented. These are the first examples of (18)F-labelled Cu(II)-complexes designed to serve as new hypoxia selective PET tracers and as mechanistic probes to study the mode of action of this class of markers. In vitro evaluation revealed that the fluorinated Cu-complex derived from amide coupling is suitable for in vivo work.",

author = "Laurence Carroll and Romain Bejot and Rebekka Hueting and Robert King and Paul Bonnitcha and Simon Bayly and Martin Christlieb and Dilworth, {Jonathan R} and Gee, {Antony D} and J{\'e}r{\^o}me Declerck and V{\'e}ronique Gouverneur",

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doi = "10.1039/b926980k",

language = "English",

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journal = "Chemical communications (Cambridge, England)",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Orthogonal 18F and 64Cu labelling of functionalised bis(thiosemicarbazonato) complexes

AU - Carroll, Laurence

AU - Bejot, Romain

AU - Hueting, Rebekka

AU - King, Robert

AU - Bonnitcha, Paul

AU - Bayly, Simon

AU - Christlieb, Martin

AU - Dilworth, Jonathan R

AU - Gee, Antony D

AU - Declerck, Jérôme

AU - Gouverneur, Véronique

PY - 2010

Y1 - 2010

N2 - The synthesis of three pairs of orthogonally labelled fluorinated Cu bis(thiosemicarbazonato) complexes is presented. These are the first examples of (18)F-labelled Cu(II)-complexes designed to serve as new hypoxia selective PET tracers and as mechanistic probes to study the mode of action of this class of markers. In vitro evaluation revealed that the fluorinated Cu-complex derived from amide coupling is suitable for in vivo work.

AB - The synthesis of three pairs of orthogonally labelled fluorinated Cu bis(thiosemicarbazonato) complexes is presented. These are the first examples of (18)F-labelled Cu(II)-complexes designed to serve as new hypoxia selective PET tracers and as mechanistic probes to study the mode of action of this class of markers. In vitro evaluation revealed that the fluorinated Cu-complex derived from amide coupling is suitable for in vivo work.

U2 - 10.1039/b926980k

DO - 10.1039/b926980k

M3 - Article

C2 - 20407674

SN - 1364-548X

VL - 46

SP - 4052

EP - 4054

JO - Chemical communications (Cambridge, England)

JF - Chemical communications (Cambridge, England)

IS - 23

ER -

Orthogonal 18F and 64Cu labelling of functionalised bis(thiosemicarbazonato) complexes

Abstract

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