p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells

C Hooper; E Meimaridou; M Tavassoli; G Melino; S Lovestone; R Killick

doi:10.1016/j.neulet.2007.03.026

p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells

C Hooper, E Meimaridou, M Tavassoli, G Melino, S Lovestone, R Killick

Research output: Contribution to journal › Article › peer-review

139 Citations (Scopus)

Abstract

p53 and tau are both associated with neurodegenerative disorders. Here, we show by Western blotting that p53 is upregulated approximately 2-fold in the superior temporal gyrus of Alzheimer's patients compared to healthy elderly control subjects. Moreover, p53 was found to induce phosphorylation of human 2N4R tau at the tau-1/AT8 epitope in HEK293a cells. Confocal microscopy revealed that tau and p53 were spatially separated intracellularly. Tau was found in the cytoskeletal compartment, whilst p53 was located in the nucleus, indicating that the effects of p53 on tau phosphorylation are indirect. Collectively, these findings have ramifications for neuronal death associated with Alzheimer's disease and other tauopathies. (c) 2007 Elsevier Ireland Ltd. All rights reserved

Original language	English
Pages (from-to)	34 - 37
Number of pages	4
Journal	Neuroscience Letters
Volume	418
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2007.03.026
Publication status	Published - 11 May 2007

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10.1016/j.neulet.2007.03.026

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title = "p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells",

abstract = "p53 and tau are both associated with neurodegenerative disorders. Here, we show by Western blotting that p53 is upregulated approximately 2-fold in the superior temporal gyrus of Alzheimer's patients compared to healthy elderly control subjects. Moreover, p53 was found to induce phosphorylation of human 2N4R tau at the tau-1/AT8 epitope in HEK293a cells. Confocal microscopy revealed that tau and p53 were spatially separated intracellularly. Tau was found in the cytoskeletal compartment, whilst p53 was located in the nucleus, indicating that the effects of p53 on tau phosphorylation are indirect. Collectively, these findings have ramifications for neuronal death associated with Alzheimer's disease and other tauopathies. (c) 2007 Elsevier Ireland Ltd. All rights reserved",

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T1 - p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells

AU - Hooper, C

AU - Meimaridou, E

AU - Tavassoli, M

AU - Melino, G

AU - Lovestone, S

AU - Killick, R

PY - 2007/5/11

Y1 - 2007/5/11

N2 - p53 and tau are both associated with neurodegenerative disorders. Here, we show by Western blotting that p53 is upregulated approximately 2-fold in the superior temporal gyrus of Alzheimer's patients compared to healthy elderly control subjects. Moreover, p53 was found to induce phosphorylation of human 2N4R tau at the tau-1/AT8 epitope in HEK293a cells. Confocal microscopy revealed that tau and p53 were spatially separated intracellularly. Tau was found in the cytoskeletal compartment, whilst p53 was located in the nucleus, indicating that the effects of p53 on tau phosphorylation are indirect. Collectively, these findings have ramifications for neuronal death associated with Alzheimer's disease and other tauopathies. (c) 2007 Elsevier Ireland Ltd. All rights reserved

AB - p53 and tau are both associated with neurodegenerative disorders. Here, we show by Western blotting that p53 is upregulated approximately 2-fold in the superior temporal gyrus of Alzheimer's patients compared to healthy elderly control subjects. Moreover, p53 was found to induce phosphorylation of human 2N4R tau at the tau-1/AT8 epitope in HEK293a cells. Confocal microscopy revealed that tau and p53 were spatially separated intracellularly. Tau was found in the cytoskeletal compartment, whilst p53 was located in the nucleus, indicating that the effects of p53 on tau phosphorylation are indirect. Collectively, these findings have ramifications for neuronal death associated with Alzheimer's disease and other tauopathies. (c) 2007 Elsevier Ireland Ltd. All rights reserved

U2 - 10.1016/j.neulet.2007.03.026

DO - 10.1016/j.neulet.2007.03.026

M3 - Article

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SP - 34

EP - 37

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells

Abstract

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