Abstract
Mendelian heritable pain disorders have provided insights into human pain mechanisms and suggested new analgesic drug targets. Interestingly, many of the heritable monogenic pain disorders have been mapped to mutations in genes encoding ion channels. Studies in transgenic mice have also implicated many ion channels in damage sensing and pain modulation. It seems likely that aberrant peripheral or central ion channel activity underlies or initiates many pathological pain conditions. Understanding the mechanistic basis of ion channel malfunction in terms of trafficking, localization, biophysics, and consequences for neurotransmission is a potential route to new pain therapies.
Original language | English |
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Article number | N/A |
Pages (from-to) | 3745-3752 |
Number of pages | 8 |
Journal | Journal of Clinical Investigation |
Volume | 120 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 2010 |
Keywords
- IRRITABLE-BOWEL-SYNDROME
- NA,K-ATPASE ALPHA-2 ISOFORM
- SPREADING DEPRESSION
- OF-FUNCTION MUTATIONS
- RESISTANT SODIUM-CHANNEL
- FAMILIAL HEMIPLEGIC MIGRAINE
- CALCIUM-CHANNELS
- NEUROPATHIC PAIN
- INFLAMMATORY PAIN
- PRIMARY ERYTHERMALGIA