Paligenosis: Prepare to regenerate!

Hendrik A. Messal; Catherine A. Cremona; Linxiang Lan; Axel Behrens

doi:10.15252/embj.201899206

Paligenosis: Prepare to regenerate!

Hendrik A. Messal, Catherine A. Cremona, Linxiang Lan, Axel Behrens^*

^*Corresponding author for this work

Diabetes

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Tissue injury can stimulate quiescent cells to proliferate, resulting in metaplasia, to rapidly replace damaged cells and enable regeneration. A new study describes how fully differentiated cells return to proliferation in an autophagy- and mTORC1-dependent manner. Given the striking parallels between this process in mammalian stomach and pancreas, a new term, paligenosis, is proposed for this conserved program.

Original language	English
Journal	EMBO Journal
DOIs	https://doi.org/10.15252/embj.201899206
Publication status	Accepted/In press - 1 Jan 2018

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title = "Paligenosis: Prepare to regenerate!",

abstract = "Tissue injury can stimulate quiescent cells to proliferate, resulting in metaplasia, to rapidly replace damaged cells and enable regeneration. A new study describes how fully differentiated cells return to proliferation in an autophagy- and mTORC1-dependent manner. Given the striking parallels between this process in mammalian stomach and pancreas, a new term, paligenosis, is proposed for this conserved program.",

author = "Messal, {Hendrik A.} and Cremona, {Catherine A.} and Linxiang Lan and Axel Behrens",

year = "2018",

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doi = "10.15252/embj.201899206",

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T2 - Prepare to regenerate!

AU - Messal, Hendrik A.

AU - Cremona, Catherine A.

AU - Lan, Linxiang

AU - Behrens, Axel

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Tissue injury can stimulate quiescent cells to proliferate, resulting in metaplasia, to rapidly replace damaged cells and enable regeneration. A new study describes how fully differentiated cells return to proliferation in an autophagy- and mTORC1-dependent manner. Given the striking parallels between this process in mammalian stomach and pancreas, a new term, paligenosis, is proposed for this conserved program.

AB - Tissue injury can stimulate quiescent cells to proliferate, resulting in metaplasia, to rapidly replace damaged cells and enable regeneration. A new study describes how fully differentiated cells return to proliferation in an autophagy- and mTORC1-dependent manner. Given the striking parallels between this process in mammalian stomach and pancreas, a new term, paligenosis, is proposed for this conserved program.

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U2 - 10.15252/embj.201899206

DO - 10.15252/embj.201899206

M3 - Article

C2 - 29567644

AN - SCOPUS:85044236771

SN - 0261-4189

JO - EMBO Journal

JF - EMBO Journal

ER -

Paligenosis: Prepare to regenerate!

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